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公开(公告)号：US20180155384A1
公开(公告)日：2018-06-07
申请号：US15884052
申请日：2018-01-30
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus infection with one or more nucleosides, nucleotides and nucleotide analogs.
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公开(公告)号：US09932363B2
公开(公告)日：2018-04-03
申请号：US15215434
申请日：2016-07-20
IPC分类号： A01N43/04 , A61K31/70 , C07H19/06 , C07H19/20 , C07H19/16 , C07H19/10 , A61K31/7072 , A61K31/7068 , A61K31/708 , A61K45/06 , A61K31/7076
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US09862743B2
公开(公告)日：2018-01-09
申请号：US14510451
申请日：2014-10-09
发明人： Leonid Beigelman , Guangyi Wang , David Bernard Smith , Marija Prhavc , Christian Andreas Jekle , Jerome Deval
IPC分类号： A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07H19/20 , C07H19/06 , C07H19/16 , C07H19/10 , C07H19/11 , C07H19/207 , C07H19/213
CPC分类号： C07H19/20 , A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/16 , C07H19/207 , C07H19/213
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.
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公开(公告)号：US09605018B2
公开(公告)日：2017-03-28
申请号：US14608523
申请日：2015-01-29
发明人： Guangyi Wang , Leonid Beigelman
IPC分类号： A61K31/70 , C07H19/04 , A01N43/04 , C07H19/10 , C07H19/20 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/207 , A61K31/381 , A61K31/497
CPC分类号： C07H19/20 , A61K31/381 , A61K31/497 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K45/06 , C07H19/10 , C07H19/207
摘要： Disclosed herein are phosphorothioate nucleotide analogs, methods of synthesizing phosphorothioate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphorothioate nucleotide analogs.
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公开(公告)号：US20160318967A1
公开(公告)日：2016-11-03
申请号：US15215434
申请日：2016-07-20
IPC分类号： C07H19/06 , A61K31/7072 , A61K31/7068 , C07H19/20 , C07H19/16 , A61K31/708 , A61K31/7076 , A61K45/06 , C07H19/10
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US20160045528A1
公开(公告)日：2016-02-18
申请号：US14816843
申请日：2015-08-03
IPC分类号： A61K31/7068 , A61K31/4436 , A61K38/21 , A61K31/437 , A61K31/7056 , C12N7/00 , A61K39/42
CPC分类号： A61K31/7068 , A61K31/437 , A61K31/4436 , A61K31/7056 , A61K38/162 , A61K38/21 , A61K39/42 , A61K2039/505 , C12N7/00 , C12N2760/18511 , A61K2300/00
摘要： Disclosed herein are a combination of compounds and methods of using the combination of compounds for ameliorating, treating and/or preventing a paramyxovirus viral infection.
摘要翻译： 本文公开了化合物和使用化合物的组合来改善，治疗和/或预防副粘病毒病毒感染的方法的组合。
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公开(公告)号：US10144755B2
公开(公告)日：2018-12-04
申请号：US15256345
申请日：2016-09-02
IPC分类号： C07H19/10 , C07H19/06 , C07H19/20 , C07H19/173 , C07H19/16 , C07H19/207 , C07H19/213
摘要： Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
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公开(公告)号：US20180065932A1
公开(公告)日：2018-03-08
申请号：US15678901
申请日：2017-08-16
发明人： Guangyi Wang , Leonid Beigelman , Anh Truong , Carmela Napolitano , Daniele Andreotti , Haiying He , Karin Ann Stein
IPC分类号： C07D213/40 , A61K45/06 , A61K31/437 , A61K31/4355 , A61K31/444 , A61K31/4709 , C07D401/04 , C07D409/04 , C07D495/14 , C07D413/04 , C07D417/04 , C07D239/34 , C07D471/04 , C07D213/65 , C07D401/12 , C07D491/048 , C07D233/64 , C07D409/14 , C07D417/06 , C07D413/12 , C07D413/06 , C07D401/06 , C07D405/12 , A61K31/4436 , C07D417/12 , C07D207/273 , A61K31/505 , A61K31/427 , A61K31/4196 , A61K31/422 , A61K31/4365 , A61K31/4439 , A61K31/4178 , A61K31/4418 , C07D491/052
CPC分类号： C07D213/40 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/505 , A61K45/06 , A61K2300/00 , C07D207/273 , C07D213/65 , C07D233/64 , C07D239/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D471/04 , C07D491/048 , C07D491/052 , C07D495/14 , C12N2760/18511
摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号：US20170283429A1
公开(公告)日：2017-10-05
申请号：US15627757
申请日：2017-06-20
发明人： Guangyi Wang , Leonid Beigelman , Anh Truong , Carmela Napolitano , Daniele Andreotti , Haiying He
IPC分类号： C07D495/04 , A61K31/404 , C07D209/14 , A61K31/381 , C07D333/58 , A61K31/4164 , C07D233/64 , A61K31/341 , C07D307/40 , C07D417/12 , A61K31/427 , C07D409/12 , A61K31/4436 , A61K31/497 , A61K31/506 , A61K31/40 , C07D207/335 , C07C243/18 , A61K31/165 , C07D333/20 , A61K31/47 , C07D215/12 , A61K31/343 , C07D307/81 , C07D307/91 , A61K31/428 , C07D277/64 , C07D333/76 , C07D213/42 , A61K31/444 , A61K31/382 , C07D335/06 , C07D311/68 , A61K31/352 , C07C255/66 , A61K31/277 , A61K31/4365 , A61K31/4025 , A61K31/538 , C07D413/12 , A61K31/5377 , A61K31/423 , C07D261/20 , C07D409/04 , A61K31/4196 , A61K31/4704 , C07D215/38 , A61K31/501 , C07D417/04 , C07D409/14 , C07D413/14 , A61K31/4545 , A61K31/4439 , C07D213/65 , C07D405/12 , A61K31/4427 , C07D213/68 , C07D405/10 , C07D401/10 , C07D405/04 , A61K31/4725 , A61K31/4709 , A61K31/496 , A61K31/4375 , C07D471/04 , A61K45/06
CPC分类号： C07D495/04 , A61K31/165 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/407 , A61K31/4155 , A61K31/4164 , A61K31/4196 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4365 , A61K31/4375 , A61K31/4418 , A61K31/4427 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K45/06 , C07C243/18 , C07C243/34 , C07C251/80 , C07C251/84 , C07C255/34 , C07C255/66 , C07C2602/08 , C07D207/335 , C07D209/08 , C07D209/14 , C07D209/20 , C07D209/86 , C07D213/42 , C07D213/50 , C07D213/65 , C07D213/68 , C07D215/12 , C07D215/14 , C07D215/38 , C07D215/42 , C07D217/24 , C07D233/38 , C07D233/60 , C07D233/61 , C07D233/64 , C07D233/88 , C07D261/20 , C07D277/56 , C07D277/64 , C07D307/40 , C07D307/52 , C07D307/81 , C07D307/91 , C07D311/68 , C07D333/16 , C07D333/20 , C07D333/50 , C07D333/54 , C07D333/58 , C07D333/62 , C07D333/66 , C07D333/68 , C07D333/76 , C07D335/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/04 , C07D495/14 , A61K2300/00
摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号：US20160176910A1
公开(公告)日：2016-06-23
申请号：US14971926
申请日：2015-12-16
摘要： Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus infection with one or more nucleosides, nucleotides and nucleotide analogs.
摘要翻译： 本文公开了核苷，核苷酸和核苷酸类似物，其合成方法以及用一种或多种核苷，核苷酸和核苷酸类似物治疗疾病和/或病症如微小RNA病毒感染的方法。
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