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    Electrophotographic organophotoreceptors with novel charge transport materials
    4.
    发明申请
    Electrophotographic organophotoreceptors with novel charge transport materials 有权
    具有新型电荷传输材料的电子照相有机光感受器

    公开(公告)号：US20050123849A1

    公开(公告)日：2005-06-09

    申请号：US10983020

    申请日：2004-11-05

    Applicant: Kam Law ,  Nusrallah Jubran ,  Zbigniew Tokarski ,  Alan Katritzky ,  Ritu Jain ,  Rexiat Maimait

    Inventor： Kam Law ,  Nusrallah Jubran ,  Zbigniew Tokarski ,  Alan Katritzky ,  Ritu Jain ,  Rexiat Maimait

    IPC: C07C251/84 ,  C07C317/34 ,  C07D207/34 ,  C07D231/38 ,  C07D249/18 ,  C07D257/06 ,  C07D333/48 ,  G03G5/06 ,  G03G5/10 ,  G03G9/12 ,  G03G15/10 ,  C07D231/18

    CPC classification number: C07D231/38 ,  C07C251/84 ,  C07C317/34 ,  C07C2603/18 ,  C07D207/34 ,  C07D249/18 ,  C07D257/06 ,  C07D333/48 ,  G03G5/0616 ,  G03G5/0618 ,  G03G5/062 ,  G03G5/0661

    Abstract: This invention relates to a novel organophotoreceptor that includes: (a) a charge transport material comprising a fluorenone hydrazone having a) least two fluorenone alkylsulfonylphenylhydrazone groups, b) at least two fluorenone pyrrolylhydrazone groups, c) at least two fluorenone benzotriazolylhydrazone groups, d) at least two fluorenone sulfolanylhydrazone groups, e) at least two fluorenone pyrazolylhydrazone groups, f) at least two fluorenone naphthylhydrazone groups, g) at least two fluorenone tetrazolylhydrazone groups, h) at least two fluorenone stilbenylhydrazone groups, or i) at least two fluorenone(9H-fluoren-9-ylidene)benzylhydrazone groups. Some of these fluoreneones may be represented by the formula where n is an integer between 2 and 6, inclusive; R1 is hydrogen, alkyl, or aryl; R2 is alkylsulfonylphenyl or one of its derivatives; X is a linking group having the formula —(CH2)m—, branched or linear. The compounds may form electrostatic imaging systems in combination with (b) a charge generating compound; and (c) an electrically conductive substrate.

    Abstract translation: 本发明涉及一种新型有机光感受器，其包括：（a）电荷传输材料，其包含芴酮腙，其具有a）至少两个芴酮烷基磺酰基苯腙基团，b）至少两个芴酮吡咯基腙基团，c）至少两个芴酮苯并三唑基腙基团，d） 至少两个芴酮砜基腙基团，e）至少两个芴酮吡唑基腙基团，f）至少两个芴酮萘基腙基团，g）至少两个芴酮四唑腙基团，h）至少两个芴酮茋基腙基团，或i）至少两个芴酮 （9H-芴-9-亚基）苄腙基团。 这些芴酮中的一些可以由下式表示：其中n是2和6之间的整数，包括端值在内; R 1是氢，烷基或芳基; R 2是烷基磺酰基苯基或其衍生物之一; X是具有下式的连接基团 - （CH 2 CH 2）m - 支链或直链。 所述化合物可以与（b）产生电荷的化合物组合形成静电成像系统; 和（c）导电基板。

    Organophotoreceptor with charge transport material having fluorenone hydrazone groups
    5.
    发明申请
    Organophotoreceptor with charge transport material having fluorenone hydrazone groups 审中-公开
    具有芴酮腙基团的电荷传输材料的有机光感受器

    公开(公告)号：US20050069794A1

    公开(公告)日：2005-03-31

    申请号：US10671172

    申请日：2003-09-25

    Applicant: Nusrallah Jubran ,  Zbigniew Tokarski ,  Kam Law

    Inventor： Nusrallah Jubran ,  Zbigniew Tokarski ,  Kam Law

    IPC: C07C251/84 ,  C07C317/22 ,  C07C327/26 ,  C07C327/30 ,  C07D285/12 ,  C07D285/125 ,  G03G5/06 ,  G03G9/12 ,  G03G5/05

    CPC classification number: G03G5/0616 ,  C07C251/84 ,  C07C317/22 ,  C07C327/26 ,  C07C2603/18 ,  C07D285/125 ,  G03G5/0603 ,  G03G5/0607 ,  G03G5/0609 ,  G03G5/0614 ,  G03G5/0618 ,  G03G5/062 ,  G03G5/0633

    Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula where n is an integer between 2 and 6, inclusive; R1 and R2 are, independently, an alkyl group, an alkaryl group, or an aryl group with the proviso that neither R1 nor R2 is a naphthyl group, a stilbenyl group, alkylsulfonylphenyl group or a (9H-fluoren-9-ylidene)benzyl group; R3 and R4 are, independently, H, halogen, carboxyl, hydroxyl, thiol, cyano, nitro, aldehyde group, ketone group, an ether group, an ester group, a carbonyl group, an alkyl group, an alkaryl group, or an aryl group; X is a linking group having the formula —(CH2)m—, branched or linear, where m is an integer between 0 and 20, inclusive, and one or more of the methylene groups can be optionally replaced by O, S, C═O, O=S=O, a heterocyclic group, an aromatic group, urethane, urea, an ester group, a NR5 group, a CHR6 group, or a CR7R8 group where R5, R6, R7, and R8 are, independently, H, an alkyl group, an alkaryl group, a heterocyclic group, or an aryl group; and Y comprises a bond, C, N, O, S, a branched or linear —(CH2)p— group where p is an integer between 0 and 10, an aromatic group, a cycloalkyl group, a heterocyclic group, or a NR9 group where R9 is hydrogen atom, an alkyl group, or aryl group, wherein Y has a structure selected to form n bonds with the corresponding X groups; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.

    Abstract translation: 改进的有机光感受器包括在导电衬底上的导电衬底和光电导元件，光电导元件包括：（a）具有下式的电荷传输材料，其中n是2和6之间的整数，包括端值; R1和R2独立地是烷基，烷芳基或芳基，条件是R1和R2都不是萘基，茋基，烷基磺酰基苯基或（9H-芴-9-亚基）苄基 组; R 3和R 4独立地是H，卤素，羧基，羟基，硫醇，氰基，硝基，醛基，酮基，醚基，酯基，羰基，烷基，烷芳基或芳基 组; X是具有式 - （CH2）m-，分支或直链的连接基团，其中m是0和20之间的整数，包括1和20个，并且一个或多个亚甲基可以任选地被O，S，C = O，O = S = O，杂环基，芳基，氨基甲酸酯，脲，酯基，NR5基，CHR6基或CR7R8基，其中R5，R6，R7和R8独立地为H ，烷基，烷芳基，杂环基或芳基; 并且Y包含键，C，N，O，S，支链或线性 - （CH 2）p基团，其中p是0和10之间的整数，芳族基团，环烷基，杂环基或NR 9 基团，其中R9是氢原子，烷基或芳基，其中Y具有选择与相应的X基团形成n键的结构; 和（b）电荷产生化合物。 描述相应的电子照相设备和成像方法。

    Treatment of myeloma
    6.
    发明授权
    Treatment of myeloma 失效
    治疗骨髓瘤

    公开(公告)号：US06686496B1

    公开(公告)日：2004-02-03

    申请号：US10165027

    申请日：2002-06-07

    Applicant: D. Howard Miles ,  Solodnikov Sergey Yurjevich ,  Krasnykh Olga Petrovna ,  Korotkova Tatiana Alexandrovna ,  Elena A. Goun

    Inventor： D. Howard Miles ,  Solodnikov Sergey Yurjevich ,  Krasnykh Olga Petrovna ,  Korotkova Tatiana Alexandrovna ,  Elena A. Goun

    IPC: C07C20500

    CPC classification number: C07C251/84

    Abstract: The compounds of the invention which encompasses a class of compounds having the property of anti-carcinogenic activity against human myeloma r comprising 4-oxo-2-butenoic acid compounds and 3-hydrazino-2,4-dioxobutanoic acid compounds and more specifically those novel derivatives: 4-(4-Chloro-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-4-oxo-but-2-enoic acid methyl ester (OF-07); 2-{N′-[(2-Bromo-phenyl)-phenyl-methylene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester (OF-09); 2-{N′-[(4-Dimethylamino-phenyl)-phenyl-methylene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester (OF-10) and 2-{N′-[1-(4-Chloro-phenyl)-ethylidene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester (OF-20) and the use of 2-(N′-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06); 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid methyl ester (OF-13); 4-benzoyl-3 -benzoyloxy-2-(2-oxo-2H-1,4-benzoxazin-3-yl)pyrido[2,1-c][1,4]benzoxazin-1,5-dione (1F-18), 4-Chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19); and 2-(N′-Fluoren-9-ylidene-hydrazino)-4-oxo-4-phenyl-but-2-enoic acid methyl ester (1F-04) which are unique in humans as therapeutic means for the eradication human myeloma.

    Abstract translation: 本发明的化合物包括一类具有抗人类骨髓瘤抗癌活性的化合物，其包含4-氧代-2-丁烯酸化合物和3-肼基-2,4-二氧代丁酸化合物，更具体地说是那些新颖的 衍生物：4-（4-氯 - 苯基）-2-（N'-芴-9-亚基 - 肼基）-4-氧代 - 丁-2-烯酸甲酯（OF-07）; 2- {N' - [（2-溴 - 苯基） - 苯基 - 亚甲基] - 肼基} -4-氧代-4-苯基 - 丁-2-烯酸甲酯（OF-09）; 2- {N' - [（4-二甲基氨基 - 苯基） - 苯基 - 亚甲基] - 肼基} -4-氧代-4-苯基 - 丁-2-烯酸甲酯（OF-10）和2- { - [1-（4-氯 - 苯基） - 亚乙基] - 肼基} -4-氧代-4-苯基 - 丁-2-烯酸甲酯（OF-20）和使用2-（N'-Fluoren -9-亚基 - 肼基）-5,5-二甲基-4-氧代 - 己-2-烯酸甲酯（OF-06）; 4-（4-乙氧基 - 苯基）-2-（N'-芴-9-亚基 - 肼基）-2-羟基-4-氧代 - 丁酸甲酯（OF-13）; 4-苯甲酰基-3-苯甲酰氧基-2-（2-氧代-2H-1,4-苯并恶嗪-3-基）吡啶并[2,1-c] [1,4]苯并恶嗪-1,5-二酮（1F- 18），4-氯-4-（4-乙氧基 - 苯基）-2-（芴-9-亚基 - 亚氨基） - 丁-3-烯酸甲酯（3F-19）; 和2-（N'-芴-9-亚基 - 肼基）-4-氧代-4-苯基 - 丁-2-烯酸甲酯（1F-04），其在人中是独特的，作为根除人骨髓瘤的治疗手段 。

    Treatment of breast cancer
    7.
    发明授权
    Treatment of breast cancer 失效
    乳腺癌的治疗

    公开(公告)号：US06638975B1

    公开(公告)日：2003-10-28

    申请号：US10309619

    申请日：2002-12-04

    Applicant: D. Howard Miles ,  Solodnikov Sergey Yurjevich ,  Krasnykh Olga Petrovna ,  Pimenova Elena Valentinovna ,  Elena A. Goun

    Inventor： D. Howard Miles ,  Solodnikov Sergey Yurjevich ,  Krasnykh Olga Petrovna ,  Pimenova Elena Valentinovna ,  Elena A. Goun

    IPC: A61K31216

    CPC classification number: C07D231/28 ,  C07C59/90 ,  C07C251/84 ,  C07C251/86 ,  C07D207/38

    Abstract: Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N′-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (OF-06), 1-(2,4-Dimethyl-phenyl)-2,4-dihydroxy-3-(4-methyl-benzoyl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1F-07), 4-(4-Methoxy-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid (3F-10), 4-(4-Chloro-phenyl)-2,4-dioxo-3-(phenyl-hydrazono)-butyric acid ethyl ester (3F-11), 2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxy-phenyl)-but-2-enoic acid (3F-15), and 4,4-Dihydroxy-5-(4-methyl-benzoyl)-2-phenyl-2,4-dihydro-pyrazol-3-one (3F-16) as well as some novel derivatives of these compounds claimed (see Table 2). The invention also encompasses a class of the compounds with the novel property of anti-tumor activity against human breast cancer, which includes the following compounds 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid methyl ester (OF-13); 2-{N′-[1-(4-Chloro-phenyl)-ethylidene]-hydrazino}-4-oxo-4-phenyl-but-2-enoic acid methyl ester (OF-20); 2-(N′-Fluoren-9-ylidene-hydrazino)-4-oxo-4-phenyl-but-2-enoic acid methyl ester (1F-04); and 4-Chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19).

    Abstract translation: 公开了4-氧代 - 丁烯酸衍生物类的化合物以及这些化合物作为抗人肿瘤药物在乳腺癌中的惊人使用性质，其包括：2-（N'-芴-9-亚基 - 肼基）-5,5-二甲基-4-氧代 - 己-2-烯酸甲酯（OF-06），1-（2,4-二甲基 - 苯基）-2,4-二羟基-3-（4- 甲基 - 苯甲酰基）-5-氧代-2,5-二氢-1H-吡咯-2-甲酸甲酯（1F-07），4-（4-甲氧基 - 苯基）-2,4-二氧代-3-（ 苯基 - 亚肼基） - 丁酸（3F-10），4-（4-氯 - 苯基）-2,4-二氧代-3-（苯基 - 亚氨基） - 丁酸乙酯（3F-11），2-羟基 -4-氧代-4-（2,3,5,6-四氟-4-甲氧基 - 苯基） - 丁-2-烯酸（3F-15）和4,4-二羟基-5-（4-甲基 - 苯甲酰基）-2-苯基-2,4-二氢 - 吡唑-3-酮（3F-16）以及这些化合物的一些新型衍生物（参见表2）。 本发明还包括一类具有抗人乳腺癌抗肿瘤活性的新性质的化合物，其包括以下化合物4-（4-乙氧基 - 苯基）-2-（N'-芴-9-亚基 - 肼基）-2-羟基-4-氧代 - 丁酸甲酯（OF-13）; 2- {N' - [1-（4-氯 - 苯基） - 亚乙基] - 肼基} -4-氧代-4-苯基 - 丁-2-烯酸甲酯（OF-20）; 2-（N'-芴-9-亚基 - 肼基）-4-氧代-4-苯基 - 丁-2-烯酸甲酯（1F-04）; 和4-氯-4-（4-乙氧基 - 苯基）-2-（芴-9-亚基 - 亚氨基） - 丁-3-烯酸甲酯（3F-19）。

    Novel process for preparation of optically active keto steroids
    10.
    发明授权
    Novel process for preparation of optically active keto steroids 失效
    用于制备光学活性酮酸酯的新方法

    公开(公告)号：US3720713A

    公开(公告)日：1973-03-13

    申请号：US3720713D

    申请日：1969-03-21

    Applicant: ROUSEEL UCLAF

    Inventor： BUCOURT R ,  NEDELEC L ,  GASC J

    IPC: C07J1/00 ,  C07J75/00 ,  C07C103/19

    CPC classification number: C07C251/84 ,  C07C2601/08 ,  C07C2602/10 ,  C07J1/00 ,  C07J75/00

    Abstract: Intermediates in the synthesis of steroids having the formulas WHEREIN R and R'' are alkyl of one to three carbon atoms and may be different and R'''' is selected from the group consisting of a hydrazide, a semicarbazide, a semioxamazide, a lower alkanediol, a lower alkanedithiol and a lower alkoxycarbonyl hydrazine.

    Abstract translation: 合成具有式WHEREIN R和R'的类固醇的中间体是1-3个碳原子的烷基，并且可以是不同的，并且R“选自酰肼，氨基脲，半马来酰亚胺，低级链烷二醇， 低级烷二硫醇和低级烷氧基羰基肼。

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