公开(公告)号：US20240360115A1

公开(公告)日：2024-10-31

申请号：US18764292

申请日：2024-07-04

申请人： Ottawa Hospital Research Institute ,  University of Ottawa

发明人： Jean-Simon Diallo ,  Christopher Noyce Boddy ,  Mark Dornan ,  Ramya Krishnan ,  Rozanne Arulanandam ,  Fabrice Le Boeuf ,  Jeffrey Smith ,  Andrew Macklin

IPC分类号： C07D413/06 ,  A61K31/341 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00

CPC分类号： C07D413/06 ,  A61K31/501 ,  A61K45/06 ,  A61P35/02 ,  C07D207/36 ,  C07D207/38 ,  C07D207/456 ,  C07D209/48 ,  C07D231/08 ,  C07D237/14 ,  C07D307/30 ,  C07D307/58 ,  C07D307/60 ,  C07D307/66 ,  C07D317/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/06 ,  C07D471/04 ,  C12N7/00 ,  A61K31/341 ,  A61K2300/00 ,  C12N2710/10334 ,  C12N2710/10351 ,  C12N2710/10352 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2750/14151 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/20234 ,  C12N2760/20251 ,  C12N2760/20252

摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US20240239745A1

公开(公告)日：2024-07-18

申请号：US18291336

申请日：2022-08-10

申请人： BILIX CO., LTD.

发明人： MYUNG LIP KIM ,  SANG HO MA ,  KI SOO PARK ,  HEE GOO JUN ,  DA EUN KIM

IPC分类号： C07D207/337 ,  A61K47/60 ,  C07D207/333 ,  C07D207/38

CPC分类号： C07D207/337 ,  A61K47/60 ,  C07D207/333 ,  C07D207/38

摘要： In a method of synthesizing bilirubin according to an embodiment, a compound represented by Formula 3 is prepared by coupling a compound represented by Formula 1 with a compound represented by Formula 2, thereby firstly chemically synthesizing bilirubin and PEGylated bilirubin, which are usefully used in a medical product or the like.

公开(公告)号：US11795147B2

公开(公告)日：2023-10-24

申请号：US17002937

申请日：2020-08-26

申请人： Boehringer Ingelheim International GmbH

发明人： Kai Gerlach ,  Christian Eickmeier ,  Jan Magnus Kriegl ,  Lothar Kussmaul ,  Klaus Rudolf ,  Bernhard Schmid

IPC分类号： C07D207/38 ,  C07D403/04 ,  C07D471/08 ,  C07D491/044 ,  C07D498/10

CPC分类号： C07D207/38 ,  C07D403/04 ,  C07D471/08 ,  C07D491/044 ,  C07D498/10

摘要： The present invention describes compounds modulating the function of mitochondrial complex I (NADH-quinone oxidoreductase) having formula (I)

公开(公告)号：US20230322670A1

公开(公告)日：2023-10-12

申请号：US18208862

申请日：2023-06-12

申请人： Poseidon Pharmaceutical Co., Ltd. ,  Wuhan Dapeng Pharmaceutical Co., Ltd.

发明人： Fapu CHEN ,  Yuxin SHI ,  Fakai CHEN

IPC分类号： C07D207/38 ,  A61P35/00

CPC分类号： C07D207/38 ,  A61P35/00

摘要： The disclosure provides a dipyrrolidine-1-one compound represented by formula 1; R is hydrogen, C1-C5 alkyl, or benzyl; R1 is selected from thiophenyl, phenylsulfinyl, phenylsulfonyl, p-toluene sulfide, p-tosylsulfinyl, and tosyl; and R2 is selected from methyl, alkoxycarbonyl, formyl, acetoxymethyl, carboxyl, and hydrogen. The compound is prepared by a compound represented by formula 2 and a compound represented by formula 3 through a condensation reaction.

公开(公告)号：US20170283377A1

公开(公告)日：2017-10-05

申请号：US15626526

申请日：2017-06-19

申请人： British Columbia Cancer Agency Branch ,  The University of British Columbia

发明人： Luping YAN ,  Raymond J. ANDERSEN ,  Marianne Dorothy SADAR ,  Nasrin R. MAWJI ,  Carmen Adriana Banuelos

IPC分类号： C07D207/38 ,  A61K31/4015

CPC分类号： C07D207/38 ,  A61K31/4015

摘要： Compounds having a structure of Structure I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R6, Y1 and Y2 are as defined herein, and wherein at least one of R3 or R4 is a straight-chain C1-C6 haloalkyl, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.

公开(公告)号：US09682933B2

公开(公告)日：2017-06-20

申请号：US14726129

申请日：2015-05-29

申请人： British Columbia Cancer Agency Branch ,  The University of British Columbia

发明人： Luping Yan ,  Raymond J. Andersen ,  Marianne Dorothy Sadar ,  Nasrin R. Mawji ,  Carmen Adriana Banuelos

IPC分类号： C07D207/38 ,  A61K31/4015

CPC分类号： C07D207/38 ,  A61K31/4015

摘要： Compounds having a structure of Structure I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R6, Y1 and Y2 are as defined herein, and wherein at least one of R3 or R4 is a straight-chain C1-C6 haloalkyl, are provided. Uses of such compounds for treatment of various indications, including prostate cancer, as well as methods of treatment involving such compounds are also provided.

公开(公告)号：US20170096391A1

公开(公告)日：2017-04-06

申请号：US15335926

申请日：2016-10-27

申请人： UNILEVER PLC

发明人： Naresh Kumar ,  George ISKANDER

IPC分类号： C07D207/44 ,  C07D207/38 ,  A01N43/36

CPC分类号： C07D207/44 ,  A01N43/36 ,  C07D207/27 ,  C07D207/273 ,  C07D207/36 ,  C07D207/38 ,  C08F26/06 ,  A01N25/10

摘要： The present invention relates to novel lactams of formulae (I) and (II). The present invention further relates to the use of these compounds in the treatment of microbial infections and microbial contamination of surfaces, particularly infections and surface contaminations characterised by biofilm formation. Further provided are compounds of formula (I) and (II) substituted with acrylate or methacrylate groups and their attachment to surfaces or polymers to inhibit microbial contamination.

公开(公告)号：US20170066754A1

公开(公告)日：2017-03-09

申请号：US15356343

申请日：2016-11-18

申请人： SHIONOGI & CO., LTD.

发明人： Ryuichi KIYAMA ,  Yasuhiko KANDA ,  Yukio TADA ,  Toshio FUJISHITA ,  Takashi KAWASUJI ,  Shozo TAKECHI ,  Masahiro FUJI

IPC分类号： C07D417/06 ,  C07D413/06 ,  C07D409/06 ,  C07D307/46 ,  C07D409/14 ,  C07D311/24 ,  C07D407/06 ,  C07D405/06 ,  C07D403/06

CPC分类号： C07D417/06 ,  A61K31/351 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K31/5377 ,  C07D207/38 ,  C07D307/46 ,  C07D311/24 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04

摘要： The present invention provides an integrase inhibitor. The inventors have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, RC and RD taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxyl, mercapto or amino; Z is O, S or NH; RA is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like).

摘要翻译： 本发明提供了一种整合酶抑制剂。 本发明人已经发现下列具有整合酶抑制活性的式（I）化合物。 （其中R C和R D与相邻的碳原子一起形成可以是稠环的环，Y是羟基，巯基或氨基; Z是O，S或NH; A>是由表示的基团（其中，C环是含N芳香族杂环）等）

公开(公告)号：US09468209B2

公开(公告)日：2016-10-18

申请号：US14548289

申请日：2014-11-20

申请人： Nanjing Agricultural University

发明人： Sheng Qiang ,  Shiguo Chen ,  Chunlong Yang ,  Xinbin Dai ,  Yunfa Dong

IPC分类号： A01N43/36 ,  C07D207/38

CPC分类号： A01N43/36 ,  C07D207/38

摘要： A compound represented by formula (I), or (II), or a salt thereof, for eradicating weeds.

摘要翻译： 由式（I）或（II）表示的化合物或其盐，用于除草。

公开(公告)号：US09296690B2

公开(公告)日：2016-03-29

申请号：US14293879

申请日：2014-06-02

申请人： Metacine, Inc.

发明人： Bae Keun Park ,  Sung-Hwa Yoon ,  Ju-Young Park ,  Sung Hoon Park

IPC分类号： A61K31/4015 ,  C07D207/448 ,  C07D207/452 ,  C07D207/38 ,  C07D207/444 ,  C07D409/04 ,  C07D207/20 ,  C07D207/408 ,  C07D207/456

CPC分类号： C07D207/448 ,  A61K31/4015 ,  C07D207/20 ,  C07D207/38 ,  C07D207/408 ,  C07D207/444 ,  C07D207/452 ,  C07D207/456 ,  C07D409/04

摘要： The present invention is for method of treating metabolic bone disease, new compounds and pharmaceutical compositions comprising the active ingredients having inhibition effects on osteoclast differentiation. The pharmaceutical composition comprising new compounds according to the present invention can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and Paget's disease.

摘要翻译： 本发明是治疗代谢性骨病的方法，新化合物和药物组合物，其含有对破骨细胞分化具有抑制作用的活性成分。 包含根据本发明的新化合物的药物组合物可用作治疗代谢性骨疾病如骨转移癌，固体癌骨转移，通过固体癌骨转移的肌肉骨骼并发症，恶性肿瘤的高钙血症，多发性骨髓瘤，原发骨 肿瘤，骨质疏松症，类风湿关节炎，骨关节炎，牙周病，牙槽骨炎症吸收，骨吸收性炎症和佩吉特氏病。