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公开(公告)号：US20240299385A1
公开(公告)日：2024-09-12
申请号：US18561189
申请日：2022-06-03
发明人： Vincent Pericolle , Jean-Christophe Vanherck , Arnaud Didier Marie Marchand , Guillaume Albert Jacques Duvey , Rui Miguel Garcia Costa Pinto
IPC分类号： A61K31/506 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/28 , C07D207/36 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
CPC分类号： A61K31/506 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/501 , A61P25/28 , C07D207/36 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
摘要： The present invention relates to a compound of formula (I), or a tautomer, a stereoisomer, a hydrate, a solvate, a polymorph, a prodrug, an isotope, or a co-crystal thereof, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined in the description and claims. The present invention also relates to a pharmaceutical composition comprising a compound according to the invention, and a pharmaceutical acceptable carrier. The present invention also relates to the present compounds for use as a medicine and/or as diagnostics. The present invention also relates to the present compounds for use in the prevention and/or treatment of GPR17 mediated disorders, such as for example a disorder or syndrome selected from a myelination disorder and a disorder or syndrome associated with brain tissue damage.
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公开(公告)号：US20230060011A1
公开(公告)日：2023-02-23
申请号：US17946587
申请日：2022-09-16
发明人： Ian Cooper , David Orr , Andrew Wilkinson , Jonathan Finlayson , Adam Bunt , Pia Appelqvist , Hans Wallberg , Fredrik Wångsell
IPC分类号： C07D207/48 , A61P31/04 , C07D207/36 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D417/04 , C07D487/04 , C07D401/12
摘要： This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.
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公开(公告)号：US11524934B2
公开(公告)日：2022-12-13
申请号：US16605847
申请日：2018-04-18
申请人： PI INDUSTRIES LTD.
发明人： Maruti Naik , Vishal A. Mahajan , Gulab E. Walunj , Dipak D. Nivdunge , Sulur G. Manjunatha , Ruchi Garg , Santosh Shridhar Autkar , Nitin Ramesh Tembhare , Hagalavadi M. Venkatesha , Konstantin Poscharny , Alexander G. M. Klausener
IPC分类号： C07C257/12 , C07D207/00 , A01N37/00 , A01N39/00 , A01N43/00 , A01N37/52 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/50 , A01N43/52 , A01N43/56 , A01N43/653 , A01N43/78 , A01N43/84 , A01N43/90 , C07C323/45 , C07D207/36 , C07D209/12 , C07D213/81 , C07D231/44 , C07D231/56 , C07D235/04 , C07D239/26 , C07D249/08 , C07D277/68 , C07D295/16 , C07D471/04
摘要： The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.
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4.发明申请公开(公告)号：US20220380384A1
公开(公告)日：2022-12-01
申请号：US17421819
申请日：2020-01-10
发明人： Zhe WANG , Zhihong ZENG , Lei ZHANG
IPC分类号： C07D513/04 , C07D207/36 , A61P31/20
摘要： The invention relates to an internal cyclic sulphiamidine amide-aryl amide compound and a use thereof for treating hepatitis B. Specifically, disclosed is a compound that may act as an HBV replication inhibitor and that has a structure represented by chemical formula (L), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt, a hydrate or a solvent thereof. See the description for detailed definitions of each group. The present invention also relates to a pharmaceutical composition containing the compound and a use thereof for treating hepatitis B.
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公开(公告)号：US11434192B2
公开(公告)日：2022-09-06
申请号：US16452452
申请日：2019-06-25
申请人： Novartis AG
发明人： Florian Karl Kleinbeck-Riniker , Benjamin Martin , Gerhard Penn , Francesco Venturoni , Thierry Schlama , Thomas Ruch , Thomas Allmendinger , Bernhard Wietfeld , Paolo Filipponi
IPC分类号： C07C59/84 , C07C67/035 , C07C213/08 , C07C69/738 , C07C313/06 , C07C229/34 , C07D265/02 , C07D207/36 , C07C251/40 , C07C251/66 , C07C51/373
摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
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公开(公告)号：US20210221788A1
公开(公告)日：2021-07-22
申请号：US16955013
申请日：2020-01-03
发明人： Ming GUO , Jianfeng WEN , Tianzhu WU , Huirong LU , Feng XU
IPC分类号： C07D401/12 , C07D207/36
摘要： The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.
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公开(公告)号：US10995064B2
公开(公告)日：2021-05-04
申请号：US15681309
申请日：2017-08-18
发明人： Koen Vandyck , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： A61K31/4164 , A61K31/426 , C07D207/36 , C07D277/36 , C07C311/37 , C07C311/14 , A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/44 , A61K31/4453 , A61K31/4468 , C07C311/16 , C07C311/20 , C07C311/51 , C07D211/96 , C07D305/08 , C07D307/22 , C07D205/04 , C07D207/273 , C07D213/42 , C07D307/60 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/48 , C07D233/90 , C07D491/107 , C07D207/14 , C07D493/08 , C07D277/56 , C07D211/28 , C07D295/13 , C07D211/56 , C07D211/76 , C07D295/26 , C07D307/68 , A61K31/34 , A61K31/397 , A61K31/495 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D233/84 , C07D309/14 , A61K31/401 , A61K45/06
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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8.发明申请公开(公告)号：US20200255373A1
公开(公告)日：2020-08-13
申请号：US16858519
申请日：2020-04-24
发明人： Koen VANDYCK , Stefaan Julien LAST , Geert ROMBOUTS , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07C311/37 , C07C311/14 , A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/4164 , A61K31/426 , A61K31/44 , A61K31/4453 , A61K31/4468 , C07C311/16 , C07C311/20 , C07C311/51 , C07D211/96 , C07D305/08 , C07D307/22 , C07D205/04 , C07D207/273 , C07D213/42 , C07D307/60 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/48 , C07D233/90 , C07D491/107 , C07D207/14 , C07D207/36 , C07D277/56 , C07D211/28 , C07D295/13 , C07D211/56 , C07D211/76 , C07D295/26 , C07D307/68 , C07D493/08 , A61K31/34 , A61K31/397 , A61K31/495 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D233/84 , C07D309/14 , A61K31/401 , A61K45/06
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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公开(公告)号：US10676429B2
公开(公告)日：2020-06-09
申请号：US14423963
申请日：2013-08-28
发明人： Koen Vandyck , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D213/42 , C07D213/81 , C07D213/82 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07C311/37 , C07C311/14 , C07C311/16 , C07C311/20 , C07C311/51 , A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/4164 , A61K31/426 , A61K31/4453 , A61K31/4468 , C07D211/96 , C07D305/08 , C07D307/22 , C07D205/04 , C07D207/273 , C07D307/60 , C07D333/38 , C07D333/48 , C07D233/90 , C07D491/107 , C07D207/14 , C07D207/36 , C07D277/56 , C07D211/28 , C07D295/13 , C07D211/56 , C07D211/76 , C07D295/26 , C07D307/68 , C07D493/08 , A61K31/34 , A61K31/397 , A61K31/495 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D233/84 , C07D309/14 , A61K31/401 , A61K45/06
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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公开(公告)号：US10654839B2
公开(公告)日：2020-05-19
申请号：US15546167
申请日：2016-01-26
发明人： Jean-Simon Diallo , Christopher Noyce Boddy , Mark Dornan , Ramya Krishnan , Rozanne Arulanandam , Fabrice Le Boeuf , Jeffrey Smith , Andrew Macklin
IPC分类号： C07D207/36 , C07D413/06 , C07D237/14 , C07D207/38 , C07D307/60 , C07D307/66 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D409/06 , C07D307/30 , C07D307/58 , C07D405/06 , A61K45/06 , C12N7/00 , C07D207/456 , C07D317/64 , C07D417/06 , C07D471/04 , A61P35/02 , C07D209/48 , C07D231/08 , A61K31/341
摘要： Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided. Compounds of Formula (II):
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