公开(公告)号：US11603368B2

公开(公告)日：2023-03-14

申请号：US16967751

申请日：2019-02-08

申请人： ENYO PHARMA

发明人： Eric Meldrum ,  Benoît De Chassey ,  Peter Machin ,  Roberta Lanaro ,  Calum Macleod ,  Karine Fabienne Malagu ,  Nicolas Proisy ,  David Robert Vesey ,  Paul Colin Michael Winship ,  Mark Chambers ,  Jean-Laurent Paparin

IPC分类号： C07D495/04 ,  C07D413/14 ,  A61P31/14 ,  A61P31/16 ,  A61P35/00 ,  C07D333/68 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D491/107 ,  C07D333/66 ,  C07D409/14 ,  A61P29/00 ,  A61P25/28

摘要： The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

公开(公告)号：US20220411398A1

公开(公告)日：2022-12-29

申请号：US17622210

申请日：2020-06-24

申请人： University of Iowa Research Foundation

发明人： Aliasger K. Salem ,  Somaya Ali Mohammed Elsaid Abdelrahman

IPC分类号： C07D333/66 ,  A61K9/16 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00

摘要： Compounds that inhibit JNK, e.g., JNK2 and/or JNK3, such as fused thiophenes, and methods of making and using the compounds are provided.

公开(公告)号：US20220000864A1

公开(公告)日：2022-01-06

申请号：US17294915

申请日：2019-11-19

申请人： 11949098 CANADA INC.

发明人： Jean TCHERVENKOV ,  Ahmed FOUDA ,  Steven PARASKEVAS ,  Sarita NEGI

IPC分类号： A61K31/498 ,  C07D409/06 ,  C07D409/14 ,  C07D409/12 ,  C07D409/04 ,  A61K31/506 ,  A61K31/4155 ,  A61K31/496 ,  A61K31/381 ,  C07D333/66 ,  A61K31/465 ,  A61K31/4178 ,  A61K31/497 ,  A61K31/519 ,  A61K31/52 ,  A61K31/7068 ,  A61K31/513 ,  A61K31/655 ,  A61K31/131 ,  A61K31/196 ,  A61K31/198 ,  A61K31/17 ,  A61K31/675 ,  A61K31/255 ,  A61K31/047 ,  A61K31/7008 ,  A61K31/407 ,  A61K33/243 ,  A61K31/704 ,  A61K38/14 ,  A61K38/12 ,  A61K31/5517 ,  A61K31/475 ,  A61K39/395 ,  A61K35/17 ,  A61K38/19 ,  A61K31/44 ,  A61K31/404 ,  A61K31/436 ,  A61K45/06 ,  A61P37/06

摘要： The invention encompasses the novel class of compounds represented by the Formula (I), (II), (III) and (IV) below, which are modulators of RORγt: The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing autoimmune diseases and antibody mediated rejection in a patient in need thereof.

公开(公告)号：US20210155612A1

公开(公告)日：2021-05-27

申请号：US16625446

申请日：2018-06-22

申请人： KYOWA KIRIN CO., LTD.

发明人： Tomohiro DANJO ,  Hiroki YAMADA ,  Takahiro NAKAJIMA

IPC分类号： C07D405/12 ,  C07D311/68 ,  C07D311/58 ,  C07D215/38 ,  C07D401/04 ,  C07D401/12 ,  C07D213/75 ,  C07D213/63 ,  C07D213/643 ,  C07D215/40 ,  C07D215/26 ,  C07D215/233 ,  C07D215/227 ,  C07D217/02 ,  C07D471/04 ,  C07D413/12 ,  C07D263/56 ,  C07D263/57 ,  C07D277/64 ,  C07D333/66 ,  C07D491/052 ,  C07D267/14 ,  C07D313/08 ,  C07D307/83 ,  C07D307/86 ,  A61P35/00

摘要： An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like: [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, −CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].

公开(公告)号：US11014935B2

公开(公告)日：2021-05-25

申请号：US15627757

申请日：2017-06-20

申请人： JANSSEN BIOPHARMA, INC.

发明人： Guangyi Wang ,  Leonid Beigelman ,  Anh Truong ,  Carmela Napolitano ,  Daniele Andreotti ,  Haiying He

IPC分类号： C07D409/04 ,  C07D495/04 ,  C07D333/58 ,  C07D215/12 ,  C07D215/14 ,  C07D311/68 ,  C07D215/42 ,  C07D217/24 ,  C07D333/16 ,  C07D333/20 ,  C07D233/38 ,  C07D333/50 ,  C07D333/54 ,  C07D233/61 ,  C07D333/62 ,  C07D333/66 ,  C07D333/68 ,  C07D335/06 ,  C07D233/88 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D261/20 ,  C07D207/335 ,  C07D209/08 ,  C07D209/14 ,  C07D277/64 ,  C07D209/86 ,  C07D213/42 ,  C07D213/50 ,  C07D213/65 ,  C07D213/68 ,  C07D307/52 ,  C07D307/81 ,  C07D233/60 ,  C07D495/14 ,  C07C251/84 ,  A61K45/06 ,  A61K31/381 ,  A61K31/404 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  C07C243/34 ,  C07C251/80 ,  C07C255/34 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/5377 ,  C07D209/20 ,  C07D233/64 ,  C07D277/56 ,  C07D409/06 ,  C07D409/12 ,  A61K31/165 ,  A61K31/277 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/382 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/4427 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/538 ,  C07C243/18 ,  C07C255/66 ,  C07D215/38 ,  C07D307/40 ,  C07D307/91 ,  C07D333/76 ,  C07D405/10 ,  C07D413/14

摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US09815811B2

公开(公告)日：2017-11-14

申请号：US14774383

申请日：2014-03-12

申请人： CURADEV PHARMA PRIVATE LTD.

发明人： Monali Banerjee ,  Sandip Middya ,  Ritesh Shrivastava ,  Sushil Raina ,  Arjun Surya ,  Dharmendra B. Yadav ,  Veejendra K. Yadav ,  Kamal Kishore Kapoor ,  Aranapakam Venkatesan ,  Roger A. Smith ,  Scott K. Thompson

IPC分类号： C07D491/048 ,  C07D333/66 ,  C07D307/82 ,  C07D491/04 ,  C07D495/04 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D409/04 ,  C07D409/12 ,  C12Q1/26

CPC分类号： C07D333/66 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/704 ,  C07D307/82 ,  C07D409/04 ,  C07D409/12 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  C12Q1/26 ,  G01N2333/90241 ,  Y02A50/411

摘要： The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.

公开(公告)号：US09682967B2

公开(公告)日：2017-06-20

申请号：US14763544

申请日：2014-01-27

申请人： H. Lundbeck A/S

发明人： Philip James Maltas ,  Stephen Watson ,  Morten Langg{hacek over (a)}rd ,  Laurent David

IPC分类号： C07D409/04 ,  C07D213/75 ,  C07D215/38 ,  C07D333/66 ,  C07D401/04 ,  C07D403/04 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D277/46 ,  C07D213/40 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  C07D417/04 ,  C07D213/60 ,  C07D213/65 ,  C07D333/68

CPC分类号： A61K31/44 ,  A61K31/381 ,  A61K31/426 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  C07D213/40 ,  C07D213/60 ,  C07D213/65 ,  C07D213/75 ,  C07D215/38 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D277/46 ,  C07D333/66 ,  C07D333/68 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D417/04

摘要： The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.

公开(公告)号：US09434711B2

公开(公告)日：2016-09-06

申请号：US14322554

申请日：2014-07-02

申请人： Janssen Pharmaceutica, NV

发明人： Shawn T Branum ,  Raymond W Colburn ,  Scott L Dax ,  Christopher M Flores ,  Michele C Jetter ,  Yi Liu ,  Donald Ludovici ,  Mark J Macielag ,  Jay M Matthews ,  James J McNally ,  Laura M Andraka ,  Ronald K Russell ,  Ning Qin ,  Christopher Teleha ,  Kenneth M Wells ,  Scott C Youells ,  Mark A Youngman

IPC分类号： A61K31/381 ,  A61K31/541 ,  A61K31/4709 ,  A61K31/5377 ,  A61P29/02 ,  C07D333/66 ,  C07D333/36 ,  C07D495/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

CPC分类号： C07D333/66 ,  C07D333/36 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D495/04

摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.

公开(公告)号：US20130237547A1

公开(公告)日：2013-09-12

申请号：US13851988

申请日：2013-03-28

申请人： JANSSEN PHARMACEUTICA, NV

发明人： Jay M. Matthews

IPC分类号： C07D409/12 ,  C07D333/66

CPC分类号： C07D333/66 ,  C07D409/12 ,  C07D413/12

摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.

摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，R 3，R 4，R A和R B在本文中定义。

公开(公告)号：US20120190674A1

公开(公告)日：2012-07-26

申请号：US13407251

申请日：2012-02-28

申请人： Shawn T. Branum ,  Raymond W. Colburn ,  Scott L. Dax ,  Christopher M. Flores ,  Michele C. Jetter ,  Yi Liu ,  Donald Ludovici ,  Mark J. Macielag ,  Jay M. Matthews ,  James J. McNally ,  Laura M. Reaney ,  Ronald K. Russell ,  Ning Qin ,  Christopher Teleha ,  Kenneth M. Wells ,  Scott C. Youells ,  Mark A. Youngman

发明人： Shawn T. Branum ,  Raymond W. Colburn ,  Scott L. Dax ,  Christopher M. Flores ,  Michele C. Jetter ,  Yi Liu ,  Donald Ludovici ,  Mark J. Macielag ,  Jay M. Matthews ,  James J. McNally ,  Laura M. Reaney ,  Ronald K. Russell ,  Ning Qin ,  Christopher Teleha ,  Kenneth M. Wells ,  Scott C. Youells ,  Mark A. Youngman

IPC分类号： A61K31/381 ,  A61K31/4436 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5377 ,  A61P9/12 ,  A61P25/00 ,  A61P29/00 ,  A61P25/22 ,  A61P25/24 ,  A61P9/00 ,  C07D333/66 ,  A61K31/541

CPC分类号： C07D333/66 ,  C07D333/36 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D495/04

摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.

摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。