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    NITROXIDE DERIVATIVE OF ROCK KINASE INHIBITOR
    9.
    发明申请
    NITROXIDE DERIVATIVE OF ROCK KINASE INHIBITOR 有权

    公开(公告)号：US20220332726A1

    公开(公告)日：2022-10-20

    申请号：US17298676

    申请日：2020-11-18

    申请人： VIVAVISION (SHANGHAI) LTD

    发明人： Wang SHEN ,  Kui Feng DANG ,  Chao ZHANG ,  Chunming CHEN ,  Li Hong SHAN ,  Wen DING ,  Xin WANG ,  Jia Chen MI ,  Ya Bo SUN ,  Xia Xin SHENG ,  Jia Lei SHEN ,  YONG LI

    IPC分类号： C07D495/04 ,  C07D217/02 ,  C07D217/26 ,  C07D275/04

    摘要： A small molecule compound of a NO donor is a compound shown in the following structural formula I or a stereoisomer, a geometric isomer, a tautomer, a racemate, a deuterated isotopic derivative, a hydrate, a solvate, a metabolite, or a pharmaceutically acceptable salt or prodrug thereof; wherein a ring A is a substituted or unsubstituted heteroaromatic ring; X is selected from (CH2); R is a substituent of terminal —O—NO2; R1 is selected from hydrogen, a hydroxyl group, a halogen, an amino group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, or a substituted or unsubstituted heteroalkyl group; R2 and R3 are each independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, or an amino protecting group.