知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

111 条记录 (耗时 0.064 秒)

    α-Cyanoacrylates
    8.
    发明授权
    α-Cyanoacrylates 失效
    α-氰基丙烯酸酯

    公开(公告)号：US07851411B2

    公开(公告)日：2010-12-14

    申请号：US10499522

    申请日：2002-12-17

    申请人： Peter Plath ,  Norbert Götz ,  Michael Rack ,  Andreas Landes ,  Cyrill Zagar ,  Matthias Witschel ,  Klaus Groβmann

    发明人： Peter Plath ,  Norbert Götz ,  Michael Rack ,  Andreas Landes ,  Cyrill Zagar ,  Matthias Witschel ,  Klaus Groβmann

    IPC分类号： A01N43/36 ,  A01N37/00 ,  A01N37/34 ,  C07D295/104 ,  C07D305/06 ,  C07C255/07

    CPC分类号： C07D295/185 ,  A01N37/44 ,  A01N43/08 ,  A01N43/16 ,  C07C255/30 ,  C07C323/60 ,  C07C327/22 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D305/08 ,  C07D307/18 ,  C07D307/20 ,  C07D307/22 ,  C07D309/14 ,  C07D319/06 ,  C07D331/04

    摘要： α-Cyanoacrylates of the formula I, where: R1 is ORa wherein Ra is hydrogen, substituted alkyl, branched alkyl, branched alkenyl, cycloloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; is NRbRc wherein Rb is hydrogen, alkyl which may be substituted, alkenyl, alkynyl; Rc is hydrogen, alkyl which may be substituted alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; or Rb and Rc form an alkandiyl-chain which may be substituted; or is SRd wherein Rd is hydrogen, alkyl which may be substituted, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; R2 is alkyl which may be substituted; is alkenyl or alkynyl; R3 is alkyl may be substituted; is alkenyl or alkynyl; R4 is hydrogen, halogen, cyano or alkyl; and their agriculturally useful salts, processes and intermediates for their preparation; and the use of these compounds or of compositions comprising these compounds for controlling undesirable plants are described.

    摘要翻译： 式I的α-氰基丙烯酸酯，其中：R 1是OR a，其中R a是氢，取代的烷基，支链烷基，支链烯基，环烷基，杂环基，芳基，苯基烷基或烷基亚氨基; 是NRbRc，其中Rb是氢，可以被取代的烷基，烯基，炔基; Rc是氢，可以被取代的烯基，炔基，环烷基，杂环基，芳基，苯基烷基或烷基亚氨基的烷基; 或R b和R c形成可被取代的烷撑二链; 或者是其中Rd为氢的SRd，可以被取代的烷基，烯基，炔基，环烷基，杂环基，芳基，苯基烷基或烷基亚氨基; R2是可被取代的烷基; 是烯基或炔基; R3是烷基可以被取代; 是烯基或炔基; R4是氢，卤素，氰基或烷基; 及其农业上有用的盐，其制备方法和中间体; 并且描述了这些化合物或包含这些化合物的组合物用于防治不期望的植物的用途。

    Metal radionuclide chelating compounds for improved chelation kinetics
    10.
    发明授权
    Metal radionuclide chelating compounds for improved chelation kinetics 失效
    用于改善螯合动力学的金属放射性核素螯合化合物

    公开(公告)号：US5625075A

    公开(公告)日：1997-04-29

    申请号：US459414

    申请日：1995-06-02

    申请人： Ananthachari Srinivasan ,  Alan R. Fritzberg ,  David S. Jones

    发明人： Ananthachari Srinivasan ,  Alan R. Fritzberg ,  David S. Jones

    IPC分类号： A61K47/48 ,  A61K51/10 ,  C07C327/30 ,  C07C327/32 ,  C07D207/46 ,  C07D209/48 ,  C07D307/18 ,  C07D405/12 ,  C07C67/00 ,  C07C233/01 ,  C07D315/00

    CPC分类号： C07D209/48 ,  A61K47/48707 ,  A61K51/1093 ,  C07C327/30 ,  C07C327/32 ,  C07D207/46 ,  C07D307/18 ,  C07D405/12 ,  A61K2121/00 ,  A61K2123/00

    摘要： The present invention provides metal chelating compounds, to chelates and chelate-targeting agent conjugates formed from the chelating compounds, and to methods for making and using these compositions. The chelating compounds incorporate two nitrogen atoms and three sulfur atoms ("N.sub.2 S.sub.3 "), two nitrogen atoms and four sulfur atoms ("N.sub.2 S.sub.4 "), or three nitrogen atoms and three sulfur atoms ("N.sub.3 S.sub.3 "). Metals, and metal oxides, capable of being chelated by the compounds include those that are radionuclides, such as .sup.99m Tc and .sup.186/188 Re.The targeting agent portion of the chelate-targeting agent conjugates provided includes antibodies, peptides, hormones, enzymes and biological response modifiers. Methods for making the conjugates are provided and encompass the addition of a metal, or metal oxide, to a chelating compound prior to attachment to a targeting agent as well as subsequent to the attachment.Another aspect of the invention provides kits for producing chelate-targeting agent conjugates for radiopharmaceutical use.An additional aspect of the invention provides methods for using the chelate-targeting agent conjugates for diagnostic and therapeutic purposes, such as detection of a target site and delivery of a radionuclide to the site, respectively.

    摘要翻译： 本发明提供金属螯合化合物，由螯合化合物形成的螯合物和螯合靶向试剂缀合物，以及制备和使用这些组合物的方法。 螯合化合物包含两个氮原子和三个硫原子（“N2S3”），两个氮原子和四个硫原子（“N2S4”）或三个氮原子和三个硫原子（“N3S3”）。 能够被化合物螯合的金属和金属氧化物包括那些是放射性核素，例如99mTc和186 / 188Re。 提供的螯合靶向药物缀合物的靶向剂部分包括抗体，肽，激素，酶和生物反应调节剂。 提供了制备缀合物的方法，并且包括在附着到靶向剂之前以及在附着之后将金属或金属氧化物加入到螯合化合物中。 本发明的另一方面提供了用于制备用于放射性药物用途的螯合靶向剂缀合物的试剂盒。 本发明的另一方面提供了用于诊断和治疗目的的螯合靶向剂缀合物的使用方法，例如分别检测靶位点和将放射性核素递送至位点。