公开(公告)号：US12024496B2

公开(公告)日：2024-07-02

申请号：US17046663

申请日：2019-03-28

Applicant: Archer Daniels Midland Company

Inventor： Chi-Cheng Ma

IPC: C07D307/18 ,  B01J21/18 ,  B01J23/644 ,  C07D307/24

CPC classification number: C07D307/18 ,  B01J21/18 ,  B01J23/6447 ,  C07D307/24

Abstract: Disclosed herein are methods for synthesizing useful intermediates and/or products from 1,2,5,6-hexanetetrol (HTO), which itself can be derived from a sugar. In an aspect, a process is provided for production of THFDCA from 1,2,5,6-hexanetetrol (HTO). The process comprises the steps of (a) ring closing to form a ring compound and (b) oxidizing using a catalyst comprising platinum and bismuth to form an acid mixture. Step (a) may be performed before or after step (b).

公开(公告)号：US11834441B2

公开(公告)日：2023-12-05

申请号：US17112156

申请日：2020-12-04

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： Steven John Durrant ,  Nadia Ahmad ,  Elizabeth Mary Beck ,  Lidio Marx Carvalho Meireles ,  Ewa Iwona Chudyk ,  Gorka Etxebarria Jardi ,  Bhairavi Galan ,  Sara S. Hadida Ruah ,  Dennis James Hurley ,  Ronald Marcellus Knegtel ,  Timothy Donald Neubert ,  Joanne Louise Pinder ,  Joseph Pontillo ,  Robert Pullin ,  Yvonne Schmidt ,  David Matthew Shaw ,  Sarah Skerratt ,  Dean Stamos ,  Stephen Andrew Thomson ,  Anisa Nizarali Virani ,  Christopher Wray

IPC: C07D405/12 ,  C07D307/24 ,  C07D405/14

CPC classification number: C07D405/12 ,  C07D307/24 ,  C07D405/14 ,  C07B2200/13

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：US10988435B2

公开(公告)日：2021-04-27

申请号：US16880146

申请日：2020-05-21

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming Zhang ,  Meenakshi S. Venkatraman ,  Cyrus K. Becker

IPC: C07C69/734 ,  C07C69/74 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  A61K9/70 ,  C07D309/08 ,  C07C69/708 ,  C07C69/712 ,  C07D305/08 ,  C07C69/675 ,  C07C69/68 ,  C07C69/75 ,  C07C69/96 ,  C07D307/24 ,  C07C69/28 ,  C07D307/30

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：US10450278B2

公开(公告)日：2019-10-22

申请号：US15324658

申请日：2015-06-26

Applicant: R-Pharm Overseas Inc.

Inventor： Alexandre Vasilievich Ivachtchenko

IPC: C07D233/86 ,  C07D491/107 ,  C07D307/24 ,  C07C229/60 ,  C07C227/16 ,  A61P35/00 ,  A61K31/4166 ,  A61K31/4188

Abstract: Novel (R)-stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1, or spiro analogues thereof, which exhibit androgen receptor antagonist properties. Also provided are variants of a method for producing the same, intermediate compounds for producing compounds of formula 1, and pharmaceutical compositions containing compounds of formula 1 in the form of tablets, capsules, and/or injections. Compounds of formula 1 can be used to produce a medicinal agent suitable for treating cancers, such as prostate cancer and breast cancer. The compounds of formula 1 may have the structure: wherein R1 is OH, NH2, or an OR4 group; R2 and R3 are methyl, or R2 and R3 are a CH2—CH2 group; and R4 is C1-C4 alkyl or cyclopropyl.

公开(公告)号：US10435385B2

公开(公告)日：2019-10-08

申请号：US15871552

申请日：2018-01-15

Applicant: MITSUI CHEMICALS, INC.

Inventor： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC: C07C237/42 ,  C07D333/38 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/78 ,  A01N43/80 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/30 ,  C07D241/24 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D309/08 ,  C07D309/28 ,  C07D317/62 ,  C07D333/68 ,  A01N37/22 ,  A01N43/60 ,  C07C237/48 ,  C07D207/34 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07D317/46

Abstract: A compound represented by Formula (1): The compound can be used as insecticides.

公开(公告)号：US10316008B2

公开(公告)日：2019-06-11

申请号：US15870276

申请日：2018-01-12

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun Nan ,  Min Li ,  Zhaobing Gao ,  Yangming Zhang ,  Haining Hu ,  Haiyan Xu ,  Huanan Liu ,  Xiaoping Pi

IPC: C07D307/24 ,  A61K31/167 ,  A61K31/17 ,  A61K31/27 ,  A61K31/277 ,  A61K31/341 ,  C07C269/04 ,  C07C269/06 ,  C07C271/28 ,  C07C273/18 ,  C07C275/64 ,  C07C231/02 ,  C07C333/08 ,  C07C233/62 ,  C07C235/16 ,  C07C235/74 ,  C07C237/04 ,  C07C237/22 ,  C07C237/48

Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.

公开(公告)号：US10051861B2

公开(公告)日：2018-08-21

申请号：US15349297

申请日：2016-11-11

Applicant: BAYER CROPSCIENCE AG ,  BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Adeline Koehler ,  Bernd Alig ,  Angela Becker ,  Arnd Voerste ,  Ulrich Goergens ,  Reiner Fischer ,  Wahed Ahmed Moradi ,  Silvia Cerezo-Galvez ,  Julia Johanna Hahn ,  Kerstin Ilg ,  Hans-Georg Schwarz ,  Takuya Gomibuchi ,  Masahito Ito ,  Daiei Yamazaki ,  Katsuhiko Shibuya ,  Eiichi Shimojo

IPC: C07D207/22 ,  C07D207/34 ,  C07D211/38 ,  C07D211/72 ,  C07D211/98 ,  C07D239/28 ,  C07D241/24 ,  C07D263/28 ,  C07D277/16 ,  C07D277/18 ,  C07D277/38 ,  C07D277/54 ,  C07D279/06 ,  C07D285/08 ,  C07D295/125 ,  C07D295/13 ,  C07D305/08 ,  C07D307/24 ,  C07D307/68 ,  C07D331/04 ,  C07D333/38 ,  C07D333/48 ,  C07D401/06 ,  A01N41/10 ,  A01N41/12 ,  A01N43/40 ,  C07C323/36 ,  C07C323/44 ,  C07D213/78 ,  C07C317/40 ,  C07C323/41 ,  C07C335/16 ,  C07D213/61 ,  A01N43/08 ,  A01N43/10 ,  A01N43/36 ,  A01N43/60 ,  A01N43/84 ,  A01N43/86 ,  C07C315/02 ,  C07C317/34 ,  C07C319/20 ,  C07C323/45 ,  C07C319/14

Abstract: The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, n have the meanings given in the description—to their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation.

公开(公告)号：US20180170855A1

公开(公告)日：2018-06-21

申请号：US15735546

申请日：2016-06-14

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming ZHANG ,  Meenakshi S. VENKATRAMAN ,  Cyrus K. BECKER

IPC: C07C69/74 ,  C07C59/13 ,  C07C69/708 ,  C07C69/712 ,  C07D305/08 ,  C07C69/675 ,  C07C69/68 ,  C07C69/75 ,  C07C69/96 ,  C07D307/24 ,  C07C69/28 ,  A61K9/70 ,  C07D309/08 ,  C07C59/11 ,  C07C53/136

CPC classification number: C07C69/734 ,  A61K9/7023 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  C07C69/28 ,  C07C69/675 ,  C07C69/68 ,  C07C69/708 ,  C07C69/712 ,  C07C69/74 ,  C07C69/75 ,  C07C69/96 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/14 ,  C07D305/08 ,  C07D307/24 ,  C07D307/30 ,  C07D309/08

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：US09994601B2

公开(公告)日：2018-06-12

申请号：US15355507

申请日：2016-11-18

Applicant: University of Kansas

Inventor： Bala Subramaniam ,  Anand Ramanathan ,  Kakasaheb Y. Nandiwale ,  Andrew M. Danby ,  Raghunath V. Chaudhari

IPC: C10G1/08 ,  C08H7/00 ,  C07G1/00 ,  C07D207/34 ,  C07C37/52 ,  C07C67/00 ,  C07C41/18 ,  C07D307/24 ,  C07D307/60 ,  C07C45/67 ,  C07C45/51 ,  C07C51/00

CPC classification number: C07G1/00 ,  C07C37/52 ,  C07C41/18 ,  C07C45/51 ,  C07C45/673 ,  C07C51/00 ,  C07C67/00 ,  C07D207/34 ,  C07D307/24 ,  C07D307/60 ,  C08H6/00 ,  C10G1/086 ,  C10G2300/1014 ,  C07C59/64 ,  C07C39/08 ,  C07C49/84 ,  C07C69/92 ,  C07C49/825 ,  C07C69/734 ,  C07C49/245

Abstract: Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid mesoporous silicate catalyst under conditions sufficient to depolymerize the lignin to produce one or more aromatic monomers.

公开(公告)号：US20180134681A1

公开(公告)日：2018-05-17

申请号：US15871552

申请日：2018-01-15

Applicant: MITSUI CHEMICALS, INC.

Inventor： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC: C07D333/38 ,  C07D317/46 ,  C07D213/64 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07C237/48 ,  A01N43/60 ,  A01N37/22 ,  C07D207/416 ,  C07C327/48 ,  C07C323/42 ,  C07C317/40 ,  C07C237/42 ,  A01N43/80 ,  A01N43/78 ,  A01N43/58 ,  A01N43/56 ,  A01N43/54 ,  A01N43/42 ,  A01N43/40 ,  A01N43/30 ,  A01N43/16 ,  A01N43/12 ,  A01N43/10 ,  A01N43/08 ,  A01N37/44 ,  C07D333/68 ,  C07D317/62 ,  C07D309/28 ,  C07D309/08 ,  C07D307/84 ,  C07D307/68 ,  C07D307/24 ,  C07D277/56 ,  C07D275/03 ,  C07D263/34 ,  C07D241/24 ,  C07D239/30 ,  C07D231/16 ,  C07D231/14 ,  C07D215/52 ,  C07D213/89 ,  C07D213/82 ,  C07D213/81 ,  C07D213/73 ,  C07D207/34

CPC classification number: C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

Abstract: An object of the present invention is to provide a compound represented by Formula (1): wherein A1, A2, A3 and A4 each represent a carbon atom, a nitrogen atom or an oxidized nitrogen atom; R1 and R2 each represent a hydrogen atom, an optionally substituted alkyl group or an optionally substituted C1-C4 alkylcarbonyl group; G1 and G2 each represent an oxygen atom or a sulfur atom; X, which may be identical or different each other, represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group or a trifluoromethyl group; n is an integer of 0 to 4; and Q1 represents an optionally substituted phenyl group, an optionally substituted naphthyl group or an optionally substituted heterocyclic group; Q2 represents a phenyl group or heterocyclic group having one or more substituents, at least one of the substituent being any of a C1-C4 haloalkoxy group, a C2-C6 perfluoroalkyl group, a C1-C6 perfluoroalkylthio group, a C1-C6 perfluoroalkylsulfinyl group and a C1-C6 perfluoroalkylsulfonyl group, an insecticide comprising the compound as the active ingredient, and a process for preparation thereof.