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公开(公告)号：US10752605B2
公开(公告)日：2020-08-25
申请号：US16417664
申请日：2019-05-21
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D313/00 , C07C69/712 , C07D317/40 , C07D321/00 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07D453/02 , C07C59/54 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34 , A61K9/70 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US10246403B2
公开(公告)日：2019-04-02
申请号：US15735546
申请日：2016-06-14
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/28 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US09845305B2
公开(公告)日：2017-12-19
申请号：US15296164
申请日：2016-10-18
申请人： Corsair Pharma Inc.
发明人： Cyrus K. Becker , Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
IPC分类号： C07D321/00 , C07D307/20 , C07D317/40 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.
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公开(公告)号：US09643911B2
公开(公告)日：2017-05-09
申请号：US14829180
申请日：2015-08-18
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/28 , C07C69/68 , C07C69/75 , C07C69/675 , C07C69/96 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07D307/30 , A61K9/70 , C07C59/13 , C07C53/136 , C07C69/74 , C07C59/11
CPC分类号： C07C69/74 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US11802105B2
公开(公告)日：2023-10-31
申请号：US17207975
申请日：2021-03-22
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/675 , C07C69/68 , C07D305/08 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US11505535B2
公开(公告)日：2022-11-22
申请号：US17214460
申请日：2021-03-26
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D321/00 , C07C59/72 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C69/74 , C07C69/96 , A61K9/70
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US10464877B2
公开(公告)日：2019-11-05
申请号：US15927636
申请日：2018-03-21
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/28 , C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US09776982B2
公开(公告)日：2017-10-03
申请号：US15157574
申请日：2016-05-18
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D313/00 , A61K31/216 , C07C69/712 , C07D317/40 , C07D321/00 , C07D453/02 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07C59/54 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34 , A61K9/70 , A61K31/165 , A61K31/335 , C07C59/31
CPC分类号： C07D313/00 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31 , C07C59/54 , C07C69/712 , C07C69/734 , C07C219/16 , C07C235/20 , C07C235/34 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D321/00 , C07D453/02
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US09394227B1
公开(公告)日：2016-07-19
申请号：US14742544
申请日：2015-06-17
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/732
CPC分类号： C07C69/734 , A61K9/0014 , A61K9/7023 , A61K31/216 , A61K45/06 , C07C69/013 , C07C69/26 , C07C69/675 , C07C69/708 , C07C69/712 , C07C69/732 , C07C69/96 , C07C2601/04 , C07C2601/14 , C07C2603/14 , C07D303/48
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
摘要翻译： 本公开提供可用作曲前列素前药的曲前列腺素衍生物。 曲前列腺素衍生物可用于治疗任何对曲前列素治疗有反应的病症，包括肺动脉高压，如肺动脉高压。
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公开(公告)号：US10703706B2
公开(公告)日：2020-07-07
申请号：US16270965
申请日：2019-02-08
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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