公开(公告)号：US20240335385A1

公开(公告)日：2024-10-10

申请号：US18746810

申请日：2024-06-18

申请人： Beam Therapeutics Inc.

发明人： Cory Dane SAGO ,  Gregory Lawrence HAMILTON

IPC分类号： A61K9/127 ,  A61K31/7105 ,  A61K39/00 ,  A61K39/385 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  A61K48/00 ,  C07C219/16 ,  C07D211/22 ,  C07D295/15

CPC分类号： A61K9/1272 ,  A61K31/7105 ,  A61K39/385 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  A61K48/0033 ,  C07C219/16 ,  C07D211/22 ,  C07D295/15 ,  A61K2039/6018

摘要： The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

公开(公告)号：US20240287018A1

公开(公告)日：2024-08-29

申请号：US18438838

申请日：2024-02-12

申请人： Corsair Pharma, Inc.

发明人： Cyrus K. BECKER ,  Meenakshi S. VENKATRAMAN ,  Xiaoming ZHANG ,  Jürg R. Pfister ,  Gwenaella Rescourio

IPC分类号： C07D321/00 ,  A61K9/00 ,  A61K9/70 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02

CPC分类号： C07D321/00 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/14

摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：US20240082425A1

公开(公告)日：2024-03-14

申请号：US18340773

申请日：2023-06-23

申请人： TURN BIOTECHNOLOGIES, INC.

发明人： Mouhannad Jumaa ,  Zeeshan Kamal ,  Dipti Barman

IPC分类号： A61K48/00 ,  C07C219/12 ,  C07C219/18 ,  C07C219/06 ,  C07C219/16 ,  A61K9/127

CPC分类号： A61K48/0033 ,  C07C219/12 ,  C07C219/18 ,  C07C219/06 ,  C07C219/16 ,  A61K9/127

摘要： The disclosure relates to ionizable lipids and compositions comprising the ionizable lipids. Lipid-nanoparticle compositions comprised of an ionizable lipid, optionally in combination with other lipid components such as helper lipids, stabilization lipids and structural lipids, and a therapeutic agent, such as a nucleic acid, for delivery to mammalian cells or organs are described.

公开(公告)号：US10752605B2

公开(公告)日：2020-08-25

申请号：US16417664

申请日：2019-05-21

申请人： CORSAIR PHARMA, INC.

发明人： Cyrus K. Becker ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

IPC分类号： C07D313/00 ,  C07C69/712 ,  C07D317/40 ,  C07D321/00 ,  C07D257/06 ,  C07D263/24 ,  C07D265/30 ,  C07D295/088 ,  C07D211/60 ,  C07D295/145 ,  C07D307/20 ,  C07C219/16 ,  C07C235/20 ,  C07D453/02 ,  C07C59/54 ,  C07C69/734 ,  C07C235/34 ,  C07D207/08 ,  C07D263/26 ,  C07D317/34 ,  A61K9/70 ,  A61K31/165 ,  A61K31/216 ,  A61K31/335 ,  C07C59/31

摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：USRE47885E1

公开(公告)日：2020-03-03

申请号：US16219285

申请日：2018-12-13

申请人： Zynerba Pharmaceuticals, Inc.

发明人： Audra Lynn Strinchcomb ,  Stan Lee Banks ,  Miroslaw Jerzy Golinski ,  Jeffrey Lynn Howard ,  Dana Carmel Hammel

IPC分类号： A61K9/00 ,  A61K45/06 ,  C07C219/04 ,  A61K31/27 ,  A61K31/265 ,  A61K31/225 ,  A61K31/222 ,  C07C271/52 ,  C07C229/16 ,  C07C229/12 ,  C07C219/16 ,  A61K9/70

摘要： Described herein are cannabidiol prodrugs used in pharmaceutical compositions as well as microneedle drug delivery systems comprising a pharmaceutical compositions comprising pharmaceutically active agents (e.g., cannabidiol and prodrugs of cannabidiol) and microneedle arrays suitable for local and systemic delivery of the active agent to a mammal. Also described herein are methods of using a microneedle transdermal or topical drug delivery systems comprising pharmaceutical compositions, comprising cannabidiol and prodrugs of cannabidiol, and microneedle arrays in the treatment disease, including pancreatitis and pancreatic cancer.

公开(公告)号：US09845305B2

公开(公告)日：2017-12-19

申请号：US15296164

申请日：2016-10-18

申请人： Corsair Pharma Inc.

发明人： Cyrus K. Becker ,  Jürg R. Pfister ,  Gwenaella Rescourio ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

IPC分类号： C07D321/00 ,  C07D307/20 ,  C07D317/40 ,  C07C235/20 ,  A61K31/165 ,  C07C69/734 ,  A61K31/216 ,  A61K31/365 ,  A61K31/341 ,  A61K45/06 ,  A61K9/00 ,  C07D317/34 ,  C07C69/712 ,  C07C219/16 ,  C07D453/02 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D207/08 ,  C07D295/088 ,  C07D211/60 ,  C07D295/145 ,  C07C59/72 ,  C07C69/74 ,  C07C69/96 ,  A61K9/70

CPC分类号： C07D321/00 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/14 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02

摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.

公开(公告)号：US09645498B2

公开(公告)日：2017-05-09

申请号：US14949418

申请日：2015-11-23

申请人： SHIN-ETSU CHEMICAL CO., LTD.

发明人： Jun Hatakeyama

IPC分类号： G03F7/32 ,  C07C211/63 ,  G03F7/004 ,  C07C381/12 ,  C08F220/18 ,  C08F220/38 ,  C08F220/22 ,  C08F220/30 ,  H01L21/027 ,  G03F7/039 ,  G03F7/20 ,  C07C219/16

CPC分类号： G03F7/322 ,  C07C211/63 ,  C07C219/16 ,  C07C381/12 ,  C08F220/18 ,  C08F220/22 ,  C08F220/30 ,  C08F220/38 ,  G03F7/004 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/0397 ,  G03F7/2041 ,  G03F7/32 ,  G03F7/325 ,  H01L21/0274

摘要： The present invention provides a developer for a photosensitive resist composition, comprising a compound represented by the general formula (1) wherein R1 to R6 represent a linear, branched, or cyclic alkyl group having 1 to 4 carbon atoms; and X represents a linear or branched alkylene group having 6 to 16 carbon atoms and optionally having an ester group. There can be provided a developer that can prevent the occurrence of pattern collapse and connection between patterns, i.e. bridge defect after development and can provide a resist pattern with small edge roughness.

公开(公告)号：US5175333A

公开(公告)日：1992-12-29

申请号：US827847

申请日：1992-01-29

申请人： Judith L. Kerschner ,  Sharon M. Jureller ,  Charles C. Nunn

发明人： Judith L. Kerschner ,  Sharon M. Jureller ,  Charles C. Nunn

IPC分类号： C07C219/16 ,  C07C309/42 ,  C11D3/39

CPC分类号： C11D3/3927 ,  C07C219/16 ,  C07C309/42 ,  C11D3/393

摘要： A process is reported for preparation of quaternary ammonium type carbonate esters which are useful as bleach precursors in detergent compositions. The process involves transesterification of low molecular weight carbonates, e.g. diphenyl carbonate, with amino functionalized alcohols, e.g. dialkylaminoalkanol. Preferably the reaction involves transesterification of diphenylcarbonate with the hydroxyl compound followed by removal of phenol. Subsequent thereto the transesterified ester is quaternized with an alkylating agent. Optionally there may be a sulfonation of phenol ester subsequent to the quaternization reaction.

摘要翻译： 报道了用于制备季铵型碳酸酯的方法，其可用作洗涤剂组合物中的漂白剂前体。 该方法涉及低分子量碳酸酯的酯交换反应，例如 碳酸二苯酯，氨基官能化的醇，例如 二烷基氨基链烷醇。 反应优选包括碳酸二苯酯与羟基化合物的酯交换反应，然后除去苯酚。 随后，将酯交换的酯用烷基化剂季铵化。 任选地，在季铵化反应之后可能存在苯酚酯的磺化。

公开(公告)号：US5153348A

公开(公告)日：1992-10-06

申请号：US582271

申请日：1990-09-14

申请人： Judith L. Kerschner ,  Sharon M. Jureller

发明人： Judith L. Kerschner ,  Sharon M. Jureller

IPC分类号： B01J27/125 ,  B01J31/02 ,  C07B61/00 ,  C07C209/68 ,  C07C211/62 ,  C07C213/06 ,  C07C219/16 ,  C07C239/22 ,  C07C303/30 ,  C07C303/32 ,  C07C309/24 ,  C07C309/42 ,  C07F9/54 ,  C11D3/39 ,  C11D7/54

CPC分类号： C07C303/30 ,  C07C213/06 ,  C07C219/16 ,  C11D3/3927 ,  C11D3/393

摘要： A process is reported for preparation of quaternary ammonium-type carbonate esters which are useful as bleach precursors in detergent compositions. The process involves transesterification of low molecular weight carbonates, e.g. diphenyl carbonate, with quaternary ammonium functionalized alcohols, e.g. choline chloride. Preferably the reaction is run in a high dielectric constant aprotic solvent such as acetonitrile. The reaction may also be conducted neat utilizing liquefied carbonate reactant as a solvent medium.

公开(公告)号：US4751015A

公开(公告)日：1988-06-14

申请号：US27278

申请日：1987-03-17

申请人： Robert W. Humphreys ,  Stephen A. Madison

发明人： Robert W. Humphreys ,  Stephen A. Madison

IPC分类号： C07D295/02 ,  C07C67/00 ,  C07C215/90 ,  C07C219/16 ,  C07C219/24 ,  C07C219/34 ,  C07C291/02 ,  C07C301/00 ,  C07C309/41 ,  C07C311/53 ,  C07D211/42 ,  C07D211/46 ,  C07D233/80 ,  C07D295/08 ,  C07F9/54 ,  C11D3/39 ,  C11D3/395 ,  D06L3/02

CPC分类号： C11D3/393 ,  C11D3/392 ,  C11D3/3927

摘要： A bleach precursor compound, its peroxygen acid derivative, and detergent compositions containing these materials are disclosed herein. The bleach precursor structurally comprises a quaternized ammonium or phosphonium group linked to a carbonate moiety having a leaving group. Upon perhydrolysis in the presence of hydrogen peroxide and a basic aqueous media, there is generated a peroxycarbonic acid bleach.