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公开(公告)号:US11339139B2
公开(公告)日:2022-05-24
申请号:US16927601
申请日:2020-07-13
申请人: CORSAIR PHARMA, INC.
IPC分类号: C07D313/00 , C07C69/712 , C07D317/40 , C07D321/00 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07D453/02 , C07C59/54 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34 , A61K9/70 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31
摘要: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号:US20220110954A1
公开(公告)日:2022-04-14
申请号:US17445449
申请日:2021-08-19
IPC分类号: A61K31/6615 , A61K31/265 , C07F9/06 , C07C69/96 , C07D317/34 , A61K31/357
摘要: The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, postnatal development, and during development in the adult, organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.
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公开(公告)号:US11046666B2
公开(公告)日:2021-06-29
申请号:US16569840
申请日:2019-09-13
申请人: CORSAIR PHARMA, INC.
IPC分类号: C07D321/00 , C07D453/02 , C07D257/06 , C07C59/72 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , C07D307/20 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07D317/40 , C07C219/16 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C69/74 , C07C69/96 , A61K9/70
摘要: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号:US10826124B2
公开(公告)日:2020-11-03
申请号:US16388216
申请日:2017-07-18
发明人: Tiancheng Yi , Chunhua Hu , Yao Jiang , Lu Miao , Chengdu Liang
IPC分类号: H01M10/0525 , H01M10/0567 , C07D239/04 , C07D241/04 , C07D251/04 , C07D317/34 , C07D327/04 , H01G11/06 , H01G11/64 , H01M6/16
摘要: An electrolyte and an electrochemical device, which relates to the field of energy storage materials. The electrolyte includes an additive A, an additive B and an additive C, the additive A selected from a group consisting of multi-cyano six-membered N-heterocyclic compounds represented by Formula I-1, Formula I-2 or Formula I-3, and combinations thereof, the additive B is at least one sulfonate compound, and the additive C is at least one halogenated cyclic carbonate compound. The electrochemical device includes the above electrolyte. The electrolyte of the present disclosure can effectively passivate the surface activity of the positive electrode material, inhibit the oxidation of the electrolyte, and effectively reduce gas production of a battery, meanwhile the electrolyte can be also adsorbed catalytically active of the graphite surface to form a more stable SEI film, thereby effectively reducing side reactions
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公开(公告)号:US20190100548A1
公开(公告)日:2019-04-04
申请号:US16207285
申请日:2018-12-03
IPC分类号: C07H15/244 , C07F7/18 , C07C15/28 , C07D317/32 , C07C45/59 , C07D307/20 , C07H15/252 , C07H15/08 , C07D317/34 , C07D317/26
摘要: The invention relates to anthracycline derivative compounds for treating tumor diseases, and related methods, compositions, and kits.
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公开(公告)号:US10144753B2
公开(公告)日:2018-12-04
申请号:US14435907
申请日:2013-10-15
IPC分类号: C07H15/244 , C07D265/06 , C07D317/32 , C07D317/34 , C07H15/08 , C07H15/252 , C07D307/20 , C07C15/28 , C07C45/59 , C07D317/26 , C07F7/18
摘要: The invention relates to anthracycline derivative compounds for treating tumor diseases, and related methods, compositions, and kits.
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公开(公告)号:US20170275301A1
公开(公告)日:2017-09-28
申请号:US15464430
申请日:2017-03-21
发明人: Claudio Giuliano , Antoine Daina , Claudio Pietra
IPC分类号: C07D513/04 , C07C311/47 , C07C317/42 , C07D209/08 , C07D403/12 , C07D215/06 , C07D215/10 , C07D401/12 , C07D215/58 , C07D215/08 , C07D405/06 , C07D213/34 , C07D311/76 , C07D295/088 , C07D307/87 , C07D231/56 , C07D239/48 , C07D233/64 , C07D235/14 , C07D213/76 , C07D237/20 , C07D209/44 , C07D417/12 , C07D409/12 , C07D317/34 , C07D417/10 , C07D487/04 , C07D223/16 , C07D405/04 , C07D495/04 , C07D471/04 , C07D405/12 , C07D241/04 , C07D217/04 , C07D217/10 , C07D471/08 , C07D413/12 , C07D241/12
CPC分类号: C07D513/04 , C07C311/47 , C07C317/14 , C07C317/26 , C07C317/42 , C07C317/44 , C07C2601/02 , C07D209/04 , C07D209/08 , C07D209/44 , C07D213/34 , C07D213/76 , C07D215/06 , C07D215/08 , C07D215/10 , C07D215/58 , C07D217/04 , C07D217/10 , C07D223/16 , C07D231/56 , C07D233/64 , C07D235/14 , C07D237/20 , C07D239/26 , C07D239/48 , C07D241/04 , C07D241/12 , C07D295/088 , C07D307/87 , C07D311/76 , C07D317/34 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D495/04
摘要: Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.
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公开(公告)号:US09670175B2
公开(公告)日:2017-06-06
申请号:US14433558
申请日:2013-10-04
发明人: Hans Georg Fliri , Rhonan Lee Ford , David Arthur Scowen , Derek Gregory Batcheller , Kari Henrik Johannes Ehinger , Mats Eskil Elmer , Magnus Joakim Hansson , Karl Fredrik Lennart Sjovall
IPC分类号: A01N43/26 , A61K31/335 , C07C69/34 , C07C69/52 , C07D317/34 , C07C69/40 , C07C69/708 , C07D323/00 , C07C235/06
CPC分类号: C07D317/34 , C07C69/40 , C07C69/708 , C07C235/06 , C07D323/00
摘要: Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.
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公开(公告)号:US20160280805A1
公开(公告)日:2016-09-29
申请号:US15035008
申请日:2014-10-31
IPC分类号: C08C19/22 , C08K3/36 , C07D317/34
CPC分类号: C08C19/22 , C07D317/34 , C07D319/06 , C08C19/20 , C08F8/30 , C08F8/34 , C08F8/36 , C08F8/40 , C08K3/36
摘要: Cyclic carbonate azide having a structure according to the following formula (A) wherein R1-R5 are independently selected from the group consisting of hydrogen, C6-20 aryl, C7-36 aralkyl, and C1-30 alkyl groups; said aryl, aralkyl, and alkyl groups my optionally be substituted with heteroatoms, X is a hydrocarbon moiety having at least one carbon atom, T has the structure —N(R6)— or —O—, R6 is selected from the group consisting of hydrogen and C1-20 alkyl groups, optionally substituted with heteroatoms, k is 0, 1, or 2, m is 0 or 1, n is 0 or 1, p is 1 or 2, Z is an aliphatic or aromatic hydrocarbon moiety having at least one carbon atom, optionally substituted with heteroatoms, and Y is either (B) or C) or (D).
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公开(公告)号:US09371264B2
公开(公告)日:2016-06-21
申请号:US14153498
申请日:2014-01-13
申请人: Corsair Pharma, Inc.
发明人: Cyrus K. Becker , Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
IPC分类号: C07C59/54 , C07C69/712 , C07D317/40 , C07D321/00 , C07D453/02 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34
CPC分类号: C07D313/00 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31 , C07C59/54 , C07C69/712 , C07C69/734 , C07C219/16 , C07C235/20 , C07C235/34 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D321/00 , C07D453/02
摘要: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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