公开(公告)号：US12162834B2

公开(公告)日：2024-12-10

申请号：US17607770

申请日：2020-04-27

Applicant: Merck Patent GmbH

Inventor： Jack Bradford ,  Kevin Adlem ,  Naomi Weare ,  Vicki Poole ,  Iain Gardiner

IPC: G02F1/1333 ,  C07C69/75 ,  C09K19/20 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34

Abstract: Reactive mesogens (RMs), mixtures and formulations comprising RMs, polymers obtained from such RMs and RM mixtures, and the use of the RMs, RM mixtures and polymers in optical or electrooptical components or devices, like optical films for liquid crystal displays (LCDs).

公开(公告)号：US12084413B2

公开(公告)日：2024-09-10

申请号：US17603208

申请日：2020-07-02

Applicant: LG CHEM, LTD.

Inventor： Jae Hun Jeong ,  Sung Kyu Lee ,  Yeon Uk Choo ,  Hyun Kyu Kim ,  Seok Goo Lee

IPC: C07C67/08 ,  B01J19/00 ,  C07C67/52 ,  C07C69/75 ,  C07C69/80 ,  C07C69/82

CPC classification number: C07C67/08 ,  B01J19/0066 ,  C07C67/52 ,  C07C69/75 ,  C07C69/80 ,  C07C69/82 ,  B01J2219/00033 ,  B01J2219/0004

Abstract: The present disclosure relates to a continuous production method of a diester-based material in a continuous production process comprising a reaction part in which a total of N reaction units from a first reaction unit to an N-th reaction unit are connected in series. The method comprising the step of feeding dicarboxylic acid and a primary alcohol, wherein the feed of the primary alcohol is divided into front-end feed of being fed into a first reaction unit and rear-end feed of being fed into one or more reaction units selected among from a second reaction unit to an N-th reaction unit, wherein the amount of the rear-end feed is 5 to 80 wt % based on the total feed amount of the primary alcohol into a reaction part, and the N is an integer of 3 to 6. According to the present invention, it is possible to ensure the ease of process operation through reducing the amount of reflux compared to a typical batch process and reducing the volume of steam for heating a reactor, and to ensure the economic feasibility of a product through saving energy.

公开(公告)号：US11866402B2

公开(公告)日：2024-01-09

申请号：US17245235

申请日：2021-04-30

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming Zhang ,  Meenakshi S. Venkatraman ,  Cyrus K. Becker

IPC: C07C69/28 ,  C07C69/734 ,  C07C69/74 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  A61K9/70 ,  C07D309/08 ,  C07C69/708 ,  C07C69/712 ,  C07D305/08 ,  C07C69/675 ,  C07C69/68 ,  C07C69/75 ,  C07C69/96 ,  C07D307/24 ,  C07D307/30

CPC classification number: C07C69/734 ,  A61K9/7023 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  C07C69/28 ,  C07C69/675 ,  C07C69/68 ,  C07C69/708 ,  C07C69/712 ,  C07C69/74 ,  C07C69/75 ,  C07C69/96 ,  C07D305/08 ,  C07D307/24 ,  C07D307/30 ,  C07D309/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/14

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：US11261378B2

公开(公告)日：2022-03-01

申请号：US15539666

申请日：2015-12-17

Applicant: DIC CORPORATION

Inventor： Masahiro Horiguchi ,  Sayaka Nose ,  Akihiro Koiso

IPC: C09K19/54 ,  C07C69/753 ,  C07C69/76 ,  C07D333/22 ,  C07D339/06 ,  C07D339/08 ,  C07D407/12 ,  C07D409/12 ,  C07C323/21 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D249/06 ,  C07C327/48 ,  C07C251/24 ,  C07D207/452 ,  C07C251/86 ,  C07C251/88 ,  C07D209/12 ,  C07D277/82 ,  C07D513/04 ,  C08F20/10 ,  G02B5/30 ,  C07C69/94 ,  C07C69/75 ,  C09K19/34 ,  C07D409/14 ,  C07D305/06 ,  C07C251/78 ,  C07D403/04 ,  C07D209/40 ,  C07D303/48 ,  C09K19/32 ,  C07D495/04 ,  C07C69/757 ,  C07C245/08 ,  C07D333/36 ,  C07D307/66 ,  C07D403/12 ,  C07D417/12 ,  C07D265/16 ,  C07D249/04 ,  C07D213/74 ,  C07C251/18 ,  C07D409/06 ,  C07D333/76 ,  C07D277/64 ,  C07D209/88 ,  C09K19/38 ,  G02F1/13363 ,  C09K19/04 ,  C08F220/30

Abstract: The present invention aims to provide a polymerizable compound that has high storage stability without causing crystal precipitation when added to a polymerizable composition and to provide a polymerizable composition containing the polymerizable compound. A polymer film produced by polymerization of the polymerizable composition has a low haze, high thickness uniformity, low occurrence of nonuniform orientation, high surface hardness, high adhesiveness, and good appearances and fewer orientation defects even after ultraviolet irradiation. The present invention also aims to provide a polymer produced by polymerization of the polymerizable composition and an optically anisotropic body produced from the polymer.

公开(公告)号：US11186702B2

公开(公告)日：2021-11-30

申请号：US15580993

申请日：2017-04-17

Applicant: LG CHEM, LTD.

Inventor： Hyun Kyu Kim ,  Mi Yeon Lee ,  Yun Ki Cho ,  Jeong Ju Moon ,  Joo Ho Kim ,  Seok Ho Jeong

IPC: C08K5/11 ,  C08K5/12 ,  C08K5/1515 ,  C07C69/75 ,  C08K9/04 ,  C07C67/62 ,  C08K5/092 ,  C08K5/00

Abstract: Provided is a plasticizer composition, a resin composition and a method of preparing the same. The plasticizer composition comprises two or more kinds of cyclohexane 1,4-diester-based materials; and a citrate-based material. Particularly, a plasticizer capable of improving physical properties such as plasticizer efficiency, migration, tensile strength, elongation rate, stress migration and light resistance, which are required for sheet formulations, when used as a plasticizer for a resin composition by improving poor physical properties generated due to a structural limitation thereof, and a resin composition including the same are provided.

公开(公告)号：US11034645B2

公开(公告)日：2021-06-15

申请号：US16574538

申请日：2019-09-18

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming Zhang ,  Meenakshi S. Venkatraman ,  Cyrus K. Becker

IPC: C07C69/734 ,  C07C69/74 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  A61K9/70 ,  C07D309/08 ,  C07C69/708 ,  C07C69/712 ,  C07D305/08 ,  C07C69/675 ,  C07C69/68 ,  C07C69/75 ,  C07C69/96 ,  C07D307/24 ,  C07C69/28 ,  C07D307/30

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：US20200283369A1

公开(公告)日：2020-09-10

申请号：US16763656

申请日：2018-11-01

Applicant: Hanwha Solutions Corporation

Inventor： Ki Taeg JUNG ,  Hyo Suk KIM ,  Seong Min PARK ,  Hye Won LEE ,  Jae Heum JUNG

IPC: C07C67/303 ,  C07C69/75 ,  C08L101/00

Abstract: Provided is a hydrogenation method of a phthalate compound. According to the present invention, in the hydrogenation reaction, generation of by-products is suppressed, and thus catalytic activity is improved and life-time is extended, thereby increasing efficiency of a commercial process and economic efficiency. Further, since the hydrogenation product prepared by the present invention has high purity and a low acid value, its quality as a plasticizer is excellent, thereby being applied to a variety of products.

公开(公告)号：US20200071257A1

公开(公告)日：2020-03-05

申请号：US16574538

申请日：2019-09-18

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming ZHANG ,  Meenakshi S. VENKATRAMAN ,  Cyrus K. BECKER

IPC: C07C69/734 ,  C07C69/74 ,  C07C53/136 ,  C07C59/11 ,  C07C59/13 ,  A61K9/70 ,  C07D309/08 ,  C07C69/708 ,  C07C69/712 ,  C07D305/08 ,  C07C69/675 ,  C07C69/68 ,  C07C69/75 ,  C07C69/96 ,  C07D307/24 ,  C07C69/28 ,  C07D307/30

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

公开(公告)号：US20190264107A1

公开(公告)日：2019-08-29

申请号：US16410062

申请日：2019-05-13

Applicant: ZEON CORPORATION

Inventor： Kei SAKAMOTO ,  Kumi OKUYAMA ,  Satoshi KIRIKI

IPC: C09K19/38 ,  C08F222/24 ,  C07D277/82 ,  H01L51/00 ,  G02B5/30 ,  C07C69/75 ,  C07C69/67 ,  G02F1/1335 ,  C08F238/00 ,  C09K19/34 ,  H01L51/52

Abstract: Disclosed is a mixture containing polymerizable compounds having Formulas (III) and (IV) wherein Ar1 and Ar2 are divalent aromatic hydrocarbon or heteroaromatic ring group having D1 or D2 as a substituent; D1 and D2 are C1-C20 organic group having at least one aromatic ring selected from the group consisting of aromatic hydrocarbon ring and heteroaromatic ring; A11-A22 and B11-B22 are alicyclic or aromatic group which may have a substituent, Y11-Y22 and L11-L22 are single bond, —O—, —CO—, —CO—O—, —O—CO—, —NR21—CO—, —CO—NR22—, —O—CO—O—, —NR23—CO—O—, —O—CO—NR24— or —NR25—CO—NR26— where R21-R26 are hydrogen or C1-C6 alkyl group; R4-R9 are hydrogen, methyl group or chlorine; one of f and k is integer of 1 to 3 with the other being integer of 0 to 3; g, j, m and q are integer of 1 to 20; and h, i, n and p are 0 or 1.

公开(公告)号：US20190248982A1

公开(公告)日：2019-08-15

申请号：US16319993

申请日：2017-12-26

Applicant: LG CHEM, LTD.

Inventor： Hyun Kyu KIM ,  Mi Yeon LEE ,  Seok Ho JEONG ,  Yun Ki CHO ,  Jeong Ju MOON ,  Joo Ho KIM

IPC: C08K5/12 ,  C08F14/06 ,  C08J5/18 ,  C07C69/75

CPC classification number: C08K5/12 ,  C07C69/75 ,  C08F14/06 ,  C08J5/18 ,  C08J2327/06 ,  C08K5/00 ,  C08K2201/014 ,  C08L101/00

Abstract: The present invention relates to a plasticizer composition in which three types of cyclohexane 1,4-diester-based compounds prepared through trans-esterification and hydrogenation are mixed, wherein alkyl substituents of the dicarboxylate are a 2-ethylhexyl group and a butyl group or an isobutyl group, which has fewer carbon atoms than the 2-ethylhexyl group, so that the plasticizer composition may exhibit excellent properties in terms of stress resistance, migration resistance, plasticization efficiency, and the like while maintaining an excellent level of tensile strength and elongation rate, when used for a resin composition.