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公开(公告)号：US11802105B2
公开(公告)日：2023-10-31
申请号：US17207975
申请日：2021-03-22
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/675 , C07C69/68 , C07D305/08 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US09199902B2
公开(公告)日：2015-12-01
申请号：US14327280
申请日：2014-07-09
CPC分类号： C07C43/23 , C07C59/13 , C07C309/24 , C07F9/09 , C07F9/3808 , C08F2/26 , C08F2/30 , C08F12/22 , C08F12/30 , C08F12/34 , C08F212/08 , C08G65/2612 , C08G65/2615 , C08G65/2636 , C08G65/2639 , C08F220/06 , C08F2220/1825 , C08F2216/1433 , C08F230/02
摘要： An emulsifier for emulsion polymerization contains a compound represented by the following general formula (I).
摘要翻译： 用于乳液聚合的乳化剂含有由以下通式（I）表示的化合物。
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公开(公告)号：US09063416B2
公开(公告)日：2015-06-23
申请号：US13706771
申请日：2012-12-06
IPC分类号： G03F7/004 , C07C59/125 , G03F7/027 , G03F7/039 , C07D313/10 , C07D327/04 , C07D333/46 , C07D333/54 , C07D333/76 , C07D335/02 , C07D335/16 , C07C323/52 , C07C381/12 , C07D493/18 , C07D307/00 , C07D307/33 , C07C25/18 , C07C69/14 , C07C69/63 , C07C69/753 , C07C69/78 , C07C59/13 , C07C59/66 , C07C59/70 , C07C62/04 , C07D493/08
CPC分类号： G03F7/027 , C07C25/18 , C07C59/125 , C07C59/13 , C07C59/66 , C07C59/70 , C07C62/04 , C07C69/14 , C07C69/63 , C07C69/753 , C07C69/78 , C07C323/52 , C07C381/12 , C07C2601/08 , C07C2603/74 , C07D307/00 , C07D307/33 , C07D313/10 , C07D327/04 , C07D333/46 , C07D333/54 , C07D333/76 , C07D335/02 , C07D335/16 , C07D493/08 , C07D493/18 , G03F7/0045 , G03F7/0397
摘要： A resist composition comprising: a base component (A) that exhibits changed solubility in a developing solution by the action of acid; a photoreactive quencher (C); and an acid-generator component (B) that generates acid upon exposure, wherein the photoreactive quencher (C) contains a compound represented by general formula (c1) shown below. In the formula, R1 represents a hydrogen atom or a hydrocarbon group of 1 to 20 carbon atoms which may have a substituent; each of R2 and R3 independently represents a hydrogen atom or a hydrocarbon group of 1 to 20 carbon atoms which may have a substituent; at least two of R1 to R3 may be mutually bonded to form a ring; X represents an oxygen atom or a sulfur atom; n represents 0 or 1; and Z+ represents an organic cation.
摘要翻译： 一种抗蚀剂组合物，其包含：通过酸作用而在显影液中显示改变的溶解度的碱成分（A） 光反应猝灭剂（C）; 以及曝光时产生酸的酸发生剂成分（B），其中，所述光反应性猝灭剂（C）含有下述通式（c1）表示的化合物。 在该式中，R 1表示氢原子或可以具有取代基的1〜20个碳原子的烃基; R 2和R 3各自独立地表示氢原子或可以具有取代基的1〜20个碳原子的烃基; R 1至R 3中的至少两个可以相互键合形成环; X表示氧原子或硫原子; n表示0或1; Z +表示有机阳离子。
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公开(公告)号：US20120295980A1
公开(公告)日：2012-11-22
申请号：US13558757
申请日：2012-07-26
申请人： Ken Phares , David Mottola
发明人： Ken Phares , David Mottola
CPC分类号： C07C59/13 , A61K9/0019 , A61K9/0053 , A61K31/192 , A61K31/216 , A61K31/223 , A61K31/235 , C07C51/412 , C07C59/70 , C07C69/712 , C07C229/08 , C07C235/06 , C07C235/08 , C07C259/06 , C07C2103/10 , C07C2603/10 , C07F9/091 , C07F9/117
摘要： This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:
摘要翻译： 本发明一般涉及前列环素类似物及其用于促进血管舒张，抑制血小板聚集和血栓形成，刺激溶栓，抑制细胞增殖（包括血管重构），提供细胞保护，预防动脉粥样硬化和诱导血管生成的方法。 通常，本发明的化合物和方法在口服给药时增加了曲前列素的口服生物利用度和循环浓度。 本发明化合物具有下式：
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公开(公告)号：US08232316B2
公开(公告)日：2012-07-31
申请号：US13013155
申请日：2011-01-25
申请人： Ken Phares , David Mottola
发明人： Ken Phares , David Mottola
IPC分类号： A61K31/216 , C07C69/716
CPC分类号： C07C59/13 , A61K9/0019 , A61K9/0053 , A61K31/192 , A61K31/216 , A61K31/223 , A61K31/235 , C07C51/412 , C07C59/70 , C07C69/712 , C07C229/08 , C07C235/06 , C07C235/08 , C07C259/06 , C07C2103/10 , C07C2603/10 , C07F9/091 , C07F9/117
摘要： This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:
摘要翻译： 本发明一般涉及前列环素类似物及其用于促进血管舒张，抑制血小板聚集和血栓形成，刺激溶栓，抑制细胞增殖（包括血管重构），提供细胞保护，预防动脉粥样硬化和诱导血管生成的方法。 通常，本发明的化合物和方法在口服给药时增加了曲前列素的口服生物利用度和循环浓度。 本发明化合物具有下式：
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6.发明授权公开(公告)号：US08163727B2
公开(公告)日：2012-04-24
申请号：US12642244
申请日：2009-12-18
IPC分类号： A61K31/19 , A61K31/5375 , A61K31/40 , A61K31/397 , A61K31/445 , C07C53/08 , C07C317/02 , C07D265/28 , C07D207/00 , C07D205/04 , C07D211/00
CPC分类号： A61K31/192 , C07C59/13 , C07C59/135 , C07C235/42 , C07C317/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/10 , C07D261/02 , C07D295/192 , C07D295/26
摘要： The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
摘要翻译： 本发明涉及式（I）的取代的苯氧基乙酸，其中变量如权利要求1中所定义，作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。
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7.发明授权Use of at least one (dihydro)jasmonic acid derivative as a desquamating agent 有权使用至少一种（二氢）茉莉酸衍生物作为脱屑剂公开(公告)号：US07365097B2
公开(公告)日：2008-04-29
申请号：US10899398
申请日：2004-07-27
申请人： Michel Neuwels , Maria Dalko
发明人： Michel Neuwels , Maria Dalko
CPC分类号： C07C59/13 , C07C2601/08
摘要： Disclosed herein is the cosmetic use, as a desquamating agent, of at least one (dihydro)jasmonic acid derivative of a given formula.Further disclosed herein is a cosmetic method for smoothing the visible and/or tactile irregularities of the skin surface, for example, for smoothing wrinkles and fine lines and/or skin spots and/or smoothing the skin, comprising topically applying, to the skin, a composition comprising, in a physiologically acceptable medium, at least one (dihydro)jasmonic acid derivative and glycerine.Other embodiments disclosed herein are novel (dihydro)jasmonic acid derivatives.
摘要翻译： 本文公开了具有给定式的至少一种（二氢）茉莉酸衍生物作为脱屑剂的美容用途。 本文进一步公开的是用于平滑皮肤表面的可见和/或触觉不规则性的化妆方法，例如用于平滑皱纹和细纹和/或皮肤斑点和/或使皮肤光滑，包括局部施用于皮肤， 在生理学上可接受的介质中包含至少一种（二氢）茉莉酸衍生物和甘油的组合物。 本文公开的其它实施方案是新的（二氢）茉莉酸衍生物。
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公开(公告)号：US2083482A
公开(公告)日：1937-06-08
申请号：US5078835
申请日：1935-11-20
发明人： ADOLF STEINDORFF , PAUL HEIMKE , KARL HORST
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公开(公告)号：US20240116847A1
公开(公告)日：2024-04-11
申请号：US18370574
申请日：2023-09-20
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , A61K9/70 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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10.发明授权公开(公告)号：US09994509B2
公开(公告)日：2018-06-12
申请号：US14902955
申请日：2014-07-07
申请人： HIVIH
发明人： Benoit Ledoussal , Frédéric Le Strat , Sophie Chasset , Julien Barbion , Julie Brias , Audrey Caravano , Fabien Faivre , Sophie Vomscheid
IPC分类号： C07C59/13 , C07D311/04 , A61K31/352 , C07D491/052 , A61K31/4741 , C07D405/10 , A61K31/4184 , A61K31/192 , C07D405/04 , A61K31/4709 , C07D409/10 , A61K31/381 , A61K45/06 , C07D311/58
CPC分类号： C07C59/13 , A61K31/192 , A61K31/352 , A61K31/381 , A61K31/4184 , A61K31/4709 , A61K31/4741 , A61K45/06 , C07C2601/02 , C07C2601/08 , C07D311/04 , C07D311/58 , C07D405/04 , C07D405/10 , C07D409/10 , C07D491/052
摘要： The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
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