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11 条记录 (耗时 0.014 秒)

    Producing method of (hydroxyalkyl) alicyclic carboxylic acids and intermediates for producing the same and producing method of such intermediates
    5.
    发明授权
    Producing method of (hydroxyalkyl) alicyclic carboxylic acids and intermediates for producing the same and producing method of such intermediates 失效
    （羟基烷基）脂环族羧酸的制造方法及其制造方法和中间体的制造方法

    公开(公告)号：US06444843B1

    公开(公告)日：2002-09-03

    申请号：US09541609

    申请日：2000-04-03

    申请人： Yuuichi Satoh ,  Jun Tatsumi ,  Toshiya Iida

    发明人： Yuuichi Satoh ,  Jun Tatsumi ,  Toshiya Iida

    IPC分类号： C07C6700

    CPC分类号： C07C69/757 ,  C07C51/09 ,  C07C51/36 ,  C07C67/303 ,  C07C67/39 ,  C07C65/01 ,  C07C62/04 ,  C07C69/76

    摘要： (Acyloxyalkyl)aromatic carboxylic acids are produced by partial oxidation of alkyl substituted aromatic compounds which are represented by the following General Formula (1) CHR1R2—Ar—(R3)n  (1) (where Ar is an aromatic ring of two or greater valency, R1 is a hydrogen atom or alkyl group having a carbon number of 1 to 3, R2 is a hydrogen atom, alkyl group having a carbon number of 1 to 3, or —OCOR5 group, R3 is an alkyl group having a carbon number of 1 to 4, —COOH group, —CHO group, —CH2R4 group, or —COOR group, n is an integer of 1 to 5, R4 is a halogen atom, —OH group, or —OCOR5 group, and R5 is an alkyl group having a carbon number of 1 to 4), and carboxylic acids in the presence of oxygen using a catalyst including an element which belongs to Group VIII of the periodic table. (Hydroxyalkyl)alicyclic carboxylic acids are produced by carrying out hydrogenation and hydrolysis using the (acyloxyalkyl)carboxylic acids as a starting material.

    摘要翻译： （Acyloxalkyl）芳族羧酸通过部分氧化由以下通式（1）表示的烷基取代的芳族化合物（其中Ar是两价或更多价的芳环，R 1是氢原子或具有 碳原子数为1〜3，R2为氢原子，碳数为1〜3的烷基或-OCOR5基，R3为碳数为1〜4的烷基，-COOH基，-CHO基 ，-CH2R4基或-COOR基，n为1〜5的整数，R4为卤素原子，-OH基或-OCOR5基，R5为碳数为1〜4的烷基） 和羧酸在氧的存在下使用包括属于周期表第VIII族的元素的催化剂。 （羟基烷基）脂环族羧酸通过使用（酰氧基烷基）羧酸作为原料进行氢化和水解来制备。

    Quinate salts of the antimalarial compound mefloquine
    7.
    发明授权
    Quinate salts of the antimalarial compound mefloquine 失效
    抗疟药复方美氟喹的盐酸盐

    公开(公告)号：US4521424A

    公开(公告)日：1985-06-04

    申请号：US584183

    申请日：1984-02-27

    申请人： Jean F. Rossignol

    发明人： Jean F. Rossignol

    IPC分类号： A61K31/47 ,  A61P33/02 ,  C07C62/04 ,  C07D401/06

    CPC分类号： C07D401/06 ,  C07C62/04

    摘要： The compound of formula (I) ##STR1## possesses markedly increased solubility under aqueous conditions and improved pharmacokinetic profile against malaria-causing parasites. Pharmaceutical compositions and method of treatment of subjects with malaria are also disclosed.

    摘要翻译： 式（I）化合物（I）在水性条件下具有显着增加的溶解性，并且改善了针对引起疟疾的寄生虫的药代动力学特性。 还公开了治疗疟疾受试者的药物组合物和方法。