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1.发明授权Platinum complexes and antitumor agents containing them as an active ingredient 失效铂复合物和抗癌剂，含有它们作为活性成分
公开(公告)号：US4968826A
公开(公告)日：1990-11-06
申请号：US495169
申请日：1990-03-16
IPC分类号： A61K31/28 , A61K31/282 , A61K33/24 , A61P35/00 , C07C59/01 , C07C62/02 , C07C62/04 , C07C211/36 , C07C211/65 , C07F15/00
CPC分类号： C07C59/01 , C07C62/02 , C07C62/04 , C07F15/0093
摘要： Novel platinum complexes of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each identically of differently is lower alkyl, or R.sup.1 and R.sup.2 taken together form --(CH.sub.2)m--, and m is an integer from 2 to 5, and antitumor agents comprising the compound (I), which are effective against cisplatin-resistant ascitic murine leukemia, murine leukemia, and solid tumor, with slight hemotoxicity and nephrotoxicity.
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公开(公告)号：US4658048A
公开(公告)日：1987-04-14
申请号：US741890
申请日：1985-06-06
CPC分类号： C07F15/0093
摘要： Novel platinum (IV) complexes having potent antitumor and antibacterial activities and high water solubility with low toxicity and pharmaceutical and/or veterinarily compositions containing one or more compounds together with one or more carriers are provided.They can be prepared by reacting a corresponding platinum (II) complex with hydrogen peroxide or halogen.
摘要翻译： 提供了具有有效的抗肿瘤和抗菌活性和低毒性的高水溶性和具有一种或多种化合物以及一种或多种载体的药物和/或兽用组合物的新型铂（IV）配合物。 它们可以通过使相应的铂（II）络合物与过氧化氢或卤素反应来制备。
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公开(公告)号：US4902797A
公开(公告)日：1990-02-20
申请号：US135061
申请日：1987-12-18
申请人： Tetsushi Totani , Katsutoshi Aono , Yasuko Adachi
发明人： Tetsushi Totani , Katsutoshi Aono , Yasuko Adachi
IPC分类号： C07F17/02 , A61K31/555 , C07F15/00
CPC分类号： C07F15/0093
摘要： A compound of the formula (I): ##STR1## (wherein R is C.sub.1 -C.sub.6 alkyl, hydroxy, carboxy, C.sub.1 -C.sub.6 alkoxy, halogen or oxo; m is an integer from 2 to 7; X and Y each is chlorine or nit-rato ligand, or taken together form --OCOCH(R.sup.1)O--, OCOCOO--, ##STR2## R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, hydroxymethyl, halogmethyl or phenyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.5 alkyl; and n is an integer from 2 to 5), being useful as antitumor agents is provided.
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公开(公告)号：US4560781A
公开(公告)日：1985-12-24
申请号：US552906
申请日：1983-11-17
CPC分类号： C07F15/0093 , C07C51/418 , C07C59/06
摘要： Novel water-soluble glycolic acid platinum complexes which have more potent antitumor activity with lower nephrotoxicity than cisplatin are provided.They can be administered parenterally to mice attacked by malignant tumors.Prepared from dinitrato-platinum complexes of amines on treatment with anion exchange resins and subsequent reaction with glycolic acid.
摘要翻译： 提供了具有比顺铂更低的肾毒性的更有效的抗肿瘤活性的新型水溶性乙醇酸铂络合物。 它们可以肠胃外给予恶性肿瘤侵袭的小鼠。 由胺的二硝基铂络合物制备，用阴离子交换树脂处理，随后与乙醇酸反应。
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公开(公告)号：US4575550A
公开(公告)日：1986-03-11
申请号：US485584
申请日：1983-04-14
申请人： Tetsushi Totani
发明人： Tetsushi Totani
CPC分类号： C07H23/00 , C07F15/0093
摘要： Platinum complexes of the following formula useful as antitumor agents with less nephro-toxicity and higher water solubility than cisplatin: ##STR1## wherein X and Y respectively or taken together represent a mono- or di-valent residue of hydroxycarboxylic acids.
摘要翻译： 下式的铂络合物可用作具有较顺铂低的肾毒性和较高水溶性的抗肿瘤剂：其中X和Y分别或一起代表羟基羧酸的一价或二价残基。
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公开(公告)号：US4359425A
公开(公告)日：1982-11-16
申请号：US249455
申请日：1981-03-31
申请人： Tetsushi Totani , Kenji Yamaguchi
发明人： Tetsushi Totani , Kenji Yamaguchi
IPC分类号： A61K31/28 , A61K31/282 , A61P35/00 , C07C53/16 , C07C55/07 , C07C55/08 , C07C59/06 , C07C63/307 , C07F15/00
CPC分类号： C07C59/06 , C07C53/16 , C07C55/07 , C07C55/08 , C07C63/307 , C07F15/0093 , Y10S514/908
摘要： Organo-platinum complexes of the following formula having excellent antitumor actions: ##STR1## X and Y each or taken together is a mono- or bi-functional ligand selected from the group consisting of halogeno, nitrato, sulfonato, monocarboxylato (mono-functional), sulfato, and dicarboxylato (bi-functional);and each of n and m is an integer of 1 or 2.
摘要翻译： 具有优异抗肿瘤作用的下式的有机铂络合物：各自或一起取代的单一或二官能配体是选自卤代，硝酸根，磺酸根，单羧基（单官能） ，硫酸酯和二羧酸（双功能）; n和m各自为1或2的整数。
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公开(公告)号：US4577038A
公开(公告)日：1986-03-18
申请号：US606961
申请日：1984-05-04
申请人： Tetsushi Totani , Katsutoshi Aono
发明人： Tetsushi Totani , Katsutoshi Aono
CPC分类号： C07F15/0093
摘要： Novel platinum complexes of glycolic acid type having potent antitumor activity and high water solubility with low nephrotoxicity and a pharmaceutical composition containing one or more said compounds together with one or more carriers, diluents or excipients are provided. They can be administered parenterally to patients suffering from malignant tumors.They are prepared by passing nitrato-platinum complexes of amines through anion exchange resins and subsequent reaction with glycolic acids.
摘要翻译： 提供具有有效抗肿瘤活性和低肾毒性高水溶性的乙醇酸型新型铂络合物和含有一种或多种所述化合物与一种或多种载体，稀释剂或赋形剂的药物组合物。 它们可以肠胃外给予恶性肿瘤患者。 它们通过使胺的硝化铂络合物通过阴离子交换树脂并随后与乙醇酸反应来制备。
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