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    Method of treating disease with sulfonylamino acid derivatives
    8.
    发明授权
    Method of treating disease with sulfonylamino acid derivatives 失效
    用磺酰氨基酸衍生物治疗疾病的方法

    公开(公告)号：US06403644B1

    公开(公告)日：2002-06-11

    申请号：US09709439

    申请日：2000-11-13

    申请人： Katsuhito Sakaki ,  Hidekazu Kanazawa ,  Tsuneyuki Sugiura ,  Tohru Miyazaki ,  Hiroyukii Ohno

    发明人： Katsuhito Sakaki ,  Hidekazu Kanazawa ,  Tsuneyuki Sugiura ,  Tohru Miyazaki ,  Hiroyukii Ohno

    IPC分类号： C07C31142

    CPC分类号： C07D213/81 ,  C07C311/19 ,  C07C311/29 ,  C07C311/46 ,  C07C311/47 ,  C07D209/20 ,  C07D213/55 ,  C07D233/64 ,  C07D307/71 ,  C07D333/38

    摘要： The present invention is related to: (i) matrix metalloproteinase inhibitors containing sulfonylamino acid derivatives of the formula (Ia);  wherein R1 is hydrogen, C1-4 alkyl; R2 is hydrogen, C1-8 alkyl etc.; E is —CONR3—, in which R3 is hydrogen, C1-4 alkyl etc., —NR3CO—, —CO—O—, —O—CO— etc.; A is hydrogen, C1-8 alkyl, C3-7 cycloalkyl, or Ar; J is bond, C2-4 alkylene etc.; G is — (CH2)m—, in which m is 2, 3 or 4, or in which R6 and R7 is hydrogen, C1-8 alkyl etc.; and non-toxic salts thereof, (ii) sulfonylamino acid derivatives of the formula (Ib): wherein all the symbols are the same meaning as (i); and non-toxic salts thereof, and (iii) process for the preparation of the compound of the formula (Ib). The compounds of the formula (Ia) are useful for prevention and/or treatment of diseases induced by overexpression and excess activity of MMP. The diseases such as above, for example, are rheumatoid, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis of, invasion of or growth of tumor cell, autoimmune disease (Crohn's disease, Sjogren's syndrome etc.), disease caused by vascular emigration or infiltration of leukocytes, arterialization.

    摘要翻译： 本发明涉及：（i）含有式（Ia）的磺酰氨基酸衍生物的基质金属蛋白酶抑制剂; 其中R1是氢，C1-4烷基; R2是氢，C1-8烷基等; E是-CONR 3 - ，其中R 3是氢，C 1-4烷基等，-NR 3 CO-，-CO-O-，-O-CO-等; A是氢，C 1-8烷基，C 3-7环烷基或Ar; J为键，C2-4亚烷基等; G为 - （CH 2）m - ，其中m为2,3或4，其中R 6和R 7为氢，C 1-8烷基等; 和其无毒盐，（ii）式（Ib）的磺酰氨基酸衍生物：其中所有符号与（i）相同; 及其无毒盐，和（iii）制备式（Ib）化合物的方法。式（Ia）化合物可用于预防和/或治疗由过表达和过度活性引起的疾病 MMP。 例如上述疾病是类风湿，关节炎，异常骨吸收，骨质疏松症，牙周炎，间质性肾炎，动脉硬化，肺气肿，肝硬化，角膜损伤，肿瘤细胞侵袭或生长的转移，自身免疫性疾病（Crohn's 疾病，干燥综合征等），血管移行或白细胞浸润引起的疾病，动脉化。