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公开(公告)号：US20050171163A1
公开(公告)日：2005-08-04
申请号：US10442917
申请日：2003-05-21
申请人： Larry Bratton , Alexander Bridges , David Connor , Steven Miller , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
发明人： Larry Bratton , Alexander Bridges , David Connor , Steven Miller , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
IPC分类号： C07D233/64 , A61K31/10 , A61K31/121 , A61K31/167 , A61K31/22 , A61K31/341 , A61K31/381 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/4402 , A61K31/4439 , A61P9/10 , A61P19/02 , A61P29/00 , A61P37/06 , A61P43/00 , C07C311/03 , C07C311/27 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07C323/22 , C07D213/44 , C07D213/50 , C07D233/54 , C07D239/26 , C07D261/08 , C07D263/32 , C07D277/10 , C07D277/26 , C07D307/40 , C07D307/46 , C07D307/71 , C07D307/80 , C07D333/18 , C07D333/22 , C07D333/38 , C07D333/44 , C07D413/02 , C07D413/04
CPC分类号： C07C311/03 , C07C311/27 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07D213/50 , C07D233/64 , C07D239/26 , C07D261/08 , C07D263/32 , C07D277/10 , C07D277/26 , C07D307/46 , C07D307/71 , C07D307/80 , C07D333/22 , C07D333/38 , C07D333/44 , C07D413/04
摘要： The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists.
摘要翻译： 本发明涉及可用于治疗趋化因子介导的病症的砜。 在某些实施方案中，本发明涉及作为MCP-1受体拮抗剂的化合物。
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2.发明申请公开(公告)号：US20050075348A1
公开(公告)日：2005-04-07
申请号：US10983929
申请日：2004-11-08
申请人： Geraldine Harriman , Kenneth Carson , Daniel Flynn , Michael Solomon , Yuntao Song , Bharat Trivedi , Bruce Roth , Christine Kolz , Ly Pham , Kuai-lin Sun
发明人： Geraldine Harriman , Kenneth Carson , Daniel Flynn , Michael Solomon , Yuntao Song , Bharat Trivedi , Bruce Roth , Christine Kolz , Ly Pham , Kuai-lin Sun
IPC分类号： A61P31/18 , C07D209/42 , C07D235/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D487/04 , C07D491/04 , C07D491/08 , A61K31/519 , A61K31/52 , A61K31/53
CPC分类号： C07D401/04 , C07D209/42 , C07D235/26 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D487/04 , C07D491/04 , C07D491/08
摘要： Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.
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公开(公告)号：US07067538B2
公开(公告)日：2006-06-27
申请号：US10442917
申请日：2003-05-21
申请人： Larry D. Bratton , Alexander J. Bridges , David T. Connor , Steven R. Miller , Yuntao Song , Kuai-Lin Sun , Bharat K. Trivedi , Paul C. Unangst
发明人： Larry D. Bratton , Alexander J. Bridges , David T. Connor , Steven R. Miller , Yuntao Song , Kuai-Lin Sun , Bharat K. Trivedi , Paul C. Unangst
CPC分类号： C07C311/03 , C07C311/27 , C07C317/18 , C07C317/24 , C07C317/28 , C07C317/44 , C07D213/50 , C07D233/64 , C07D239/26 , C07D261/08 , C07D263/32 , C07D277/10 , C07D277/26 , C07D307/46 , C07D307/71 , C07D307/80 , C07D333/22 , C07D333/38 , C07D333/44 , C07D413/04
摘要： The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists.
摘要翻译： 本发明涉及可用于治疗趋化因子介导的病症的砜。 在某些实施方案中，本发明涉及作为MCP-1受体拮抗剂的化合物。
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4.发明授权Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor 有权功能化杂环作为趋化因子受体功能的调节剂及其使用方法公开(公告)号：US06951848B2
公开(公告)日：2005-10-04
申请号：US10096361
申请日：2002-03-12
申请人： Geraldine C. B. Harriman , Kenneth G. Carson , Daniel L. Flynn , Michael E. Solomon , Yuntao Song , Bharat K. Trivedi , Bruce D. Roth , Christine N. Kolz , Ly Pham , Kuai-lin Sun
发明人： Geraldine C. B. Harriman , Kenneth G. Carson , Daniel L. Flynn , Michael E. Solomon , Yuntao Song , Bharat K. Trivedi , Bruce D. Roth , Christine N. Kolz , Ly Pham , Kuai-lin Sun
IPC分类号： A61P31/18 , C07D209/42 , C07D235/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D487/04 , C07D491/04 , C07D491/08 , A61K31/33 , A61K31/40 , A61K31/405 , C07D209/04
CPC分类号： C07D401/04 , C07D209/42 , C07D235/26 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D487/04 , C07D491/04 , C07D491/08
摘要： Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.
摘要翻译： 公开了具有下式的新化合物或其生理上可接受的盐，酰胺，酯或前药。 该化合物可用于调节（拮抗，激动）趋化因子受体功能。 还公开了一种治疗患有炎性疾病和/或病毒感染的患者的方法，其包括施用有效量的式I化合物。在具体实施方案中，本发明是用于治疗感染HIV的患者的方法。
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公开(公告)号：US20050154042A1
公开(公告)日：2005-07-14
申请号：US11002821
申请日：2004-12-02
申请人： Larry Bratton , Xue-Min Cheng , Chitase Lee , Steven Miller , Jeffrey Pfefferkorn , Toni-Jo Poel , Roderick Sorenson , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
发明人： Larry Bratton , Xue-Min Cheng , Chitase Lee , Steven Miller , Jeffrey Pfefferkorn , Toni-Jo Poel , Roderick Sorenson , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
IPC分类号： A61K31/40 , C07D207/34 , C07D207/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
CPC分类号： C07D207/34 , C04B35/632 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
摘要： HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.
摘要翻译： 提供了可用作低胆固醇血症和降血脂化合物的HMGCo-A还原酶抑制剂化合物。 还提供了化合物的药物组合物。 还提供了制备方法和使用该化合物的方法。
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