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1.发明申请COMPOUNDS HAVING BOTH ANGIOTENSIN II RECEPTOR ANTAGONISM AND PPARy ACTIVATING ACTIVITIES 审中-公开具有两种血管紧张素II受体拮抗剂和PPAR活性活性的化合物公开(公告)号：US20100029710A1
公开(公告)日：2010-02-04
申请号：US12518472
申请日：2007-12-03
申请人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Chitase Lee , Hud Lawrence Risley , Robert Philip Schaum
发明人： Christopher Franklin Bigge , Agustin Casimiro-Garcia , Chitase Lee , Hud Lawrence Risley , Robert Philip Schaum
IPC分类号： A61K31/437 , C07D471/04 , A61P3/10 , A61P3/00 , A61P9/12
CPC分类号： C07D471/04
摘要： Compounds of following formula (I) are provided that have both angiotensin II receptor antagonist activity and PPARy agonist activity. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment of diseases with the compounds including type 2 diabetes, insulin resistance, hyperinsulinemia, hyperlipidemia, hypertriglyceridemia, metabolic syndrome, congestive heart failure, and hypertension.
摘要翻译： 提供了具有血管紧张素II受体拮抗剂活性和PPARγ激动剂活性的下式（I）的化合物。 还提供了包含该化合物的药物组合物和用包括2型糖尿病，胰岛素抵抗，高胰岛素血症，高脂血症，高甘油三酯血症，代谢综合征，充血性心力衰竭和高血压的化合物治疗疾病的方法。
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公开(公告)号：US06867224B2
公开(公告)日：2005-03-15
申请号：US10324266
申请日：2002-12-19
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4725 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/26 , C07D277/30 , C07D417/12
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
摘要翻译： 本发明公开了改变PPAR活性的化合物。 本发明还公开了化合物的药学上可接受的盐，包含化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。 本发明还公开了制备所公开的化合物的方法。
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公开(公告)号：US06833380B2
公开(公告)日：2004-12-21
申请号：US10324278
申请日：2002-12-19
申请人： Xue-Min Cheng , Noe Erasga , Gary Frederick Filzen , Andrew Geyer , Chitase Lee , Bharat Kalidas Trivedi
发明人： Xue-Min Cheng , Noe Erasga , Gary Frederick Filzen , Andrew Geyer , Chitase Lee , Bharat Kalidas Trivedi
IPC分类号： A61K3142
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
摘要翻译： 本发明公开了改变PPAR活性的化合物。 本发明还公开了化合物的药学上可接受的盐，包含化合物或其盐的药学上可接受的组合物，以及使用它们作为治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。 本发明还公开了制备所公开的化合物的方法。
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公开(公告)号：US20050107442A1
公开(公告)日：2005-05-19
申请号：US11025271
申请日：2004-12-24
申请人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
发明人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4725 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/26 , C07D277/30 , C07D417/12 , C07D277/18 , A61K31/4025 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , C07D263/02
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
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5.发明授权Certain benzothiazine dioxide endothelin antagonists and processes for their preparation 失效某些苯并噻嗪二氧化物内皮素拮抗剂及其制备方法公开(公告)号：US06545150B2
公开(公告)日：2003-04-08
申请号：US10006589
申请日：2001-12-05
申请人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
发明人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
IPC分类号： C07D27916
CPC分类号： C07D417/04 , C07C303/40 , C07D279/02 , C07D417/10 , C07C311/21
摘要： The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
摘要翻译： 本发明是一系列苯并噻嗪二氧化物或其药学上可接受的盐，其是具有深度体外活性的有效的内皮素A拮抗剂，以及式1的改进的合成。该化合物可用于治疗升高的内皮素水平，必需的血管性恶性和 肺动脉高压，脑梗塞，脑缺血，充血性心力衰竭和蛛网膜下腔出血。
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公开(公告)号：US06265399B1
公开(公告)日：2001-07-24
申请号：US09445504
申请日：1999-12-08
申请人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
发明人： Amy Mae Bunker , Xue-Min Cheng , Annette Marian Doherty , Jeremy John Edmunds , Gerald David Kanter , Chitase Lee , Joseph Thomas Repine , Richard William Skeean
IPC分类号： C07D27902
CPC分类号： C07D417/04 , C07C303/40 , C07D279/02 , C07D417/10 , C07C311/21
摘要： The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
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公开(公告)号：US08513436B2
公开(公告)日：2013-08-20
申请号：US13330378
申请日：2011-12-19
申请人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07D487/00 , C07D239/70 , C07D271/06 , C07D271/10 , C07D261/02 , C07D257/04
CPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
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公开(公告)号：US07109222B2
公开(公告)日：2006-09-19
申请号：US11025271
申请日：2004-12-24
IPC分类号： A61K31/426 , C07D277/30
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
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公开(公告)号：US20050154042A1
公开(公告)日：2005-07-14
申请号：US11002821
申请日：2004-12-02
申请人： Larry Bratton , Xue-Min Cheng , Chitase Lee , Steven Miller , Jeffrey Pfefferkorn , Toni-Jo Poel , Roderick Sorenson , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
发明人： Larry Bratton , Xue-Min Cheng , Chitase Lee , Steven Miller , Jeffrey Pfefferkorn , Toni-Jo Poel , Roderick Sorenson , Yuntao Song , Kuai-Lin Sun , Bharat Trivedi , Paul Unangst
IPC分类号： A61K31/40 , C07D207/34 , C07D207/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
CPC分类号： C07D207/34 , C04B35/632 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
摘要： HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.
摘要翻译： 提供了可用作低胆固醇血症和降血脂化合物的HMGCo-A还原酶抑制剂化合物。 还提供了化合物的药物组合物。 还提供了制备方法和使用该化合物的方法。
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公开(公告)号：US20050113422A1
公开(公告)日：2005-05-26
申请号：US11020391
申请日：2004-12-22
申请人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
发明人： Xue-Min Cheng , Gary Filzen , Andrew Geyer , Chitase Lee , Bharat Trivedi
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4725 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/10 , C07D277/26 , C07D277/30 , C07D417/12 , A61K31/4439 , A61K31/421 , C07D413/04 , C07D417/04
CPC分类号： C07D417/12 , C07D277/26
摘要： This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.
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