公开(公告)号：US08557991B2

公开(公告)日：2013-10-15

申请号：US12920990

申请日：2009-03-05

Applicant: Bernd Muller ,  Helmut Schlemper

Inventor： Bernd Muller ,  Helmut Schlemper

IPC: C07D471/14 ,  C07D471/04

CPC classification number: C07D471/14 ,  C07B2200/07

Abstract: Disclosed is a novel process for the preparation of pharmacologically interesting indolopyridine derivatives containing tetracyclic tetrahydro-11-carboline-hydantoines linked to a basic side chain and the corresponding salts, which can be used as Eg5 inhibitors, with very high overall chemical yield and enantiomeric purity.

Abstract translation: 公开了一种用于制备药理学上有趣的吲哚并吡啶衍生物的新方法，该衍生物含有与碱性侧链连接的四环四氢-11-咔啉 - 乙内酰脲和可用作Eg5抑制剂的相应盐，具有非常高的总化学收率和对映体纯度 。

公开(公告)号：US08322251B2

公开(公告)日：2012-12-04

申请号：US12538909

申请日：2009-08-11

Applicant: Bernd Muller ,  Mario Steinborn

Inventor： Bernd Muller ,  Mario Steinborn

IPC: F16H37/06 ,  F16H3/44 ,  B60W10/00

CPC classification number: F16H3/095 ,  F16H37/046 ,  F16H2200/0004 ,  Y10T74/19074 ,  Y10T74/19233 ,  Y10T74/19637 ,  Y10T477/6395

Abstract: A transmission arrangement (1) with at least two countershafts for a vehicle, in particular a utility vehicle is proposed, such that an auxiliary drive output (10) can be coupled by means of a torque-transmitting element (11) to a first countershaft (7), and such that a second countershaft (8) can be coupled with a transmission brake device (12) to bring about load equalization between the countershafts (7, 8) when the auxiliary output (10) is coupled to the first countershaft (7). In addition, a method is proposed for load equalization between the countershafts (7, 8) of a transfer transmission when an auxiliary output (10) is engaged, such that in a first shift position of a main group (2) of the transfer transmission, in which the second countershaft (8), not coupled to the auxiliary output (10), is free from load, a load torque is applied to the second countershaft (8) for load equalization.

Abstract translation: 提出了一种具有用于车辆，特别是多用途车辆的至少两个中间轴的变速器装置（1），使得辅助驱动输出（10）可以通过扭矩传递元件（11）联接到第一中间轴 （7），并且使得当辅助输出（10）联接到第一中间轴（10）时，第二中间轴（8）可与变速器制动装置（12）联接以实现中间轴（7,8）之间的负载均衡， （7）。 此外，当辅助输出（10）接合时，提出了一种用于在传动传动装置的中间轴（7,8）之间的负载均衡的方法，使得在传送传输的主组（2）的第一移位位置 ，其中未联接到辅助输出（10）的第二中间轴（8）没有负载，负载扭矩施加到第二中间轴（8）以进行负载均衡。

公开(公告)号：US20110183842A1

公开(公告)日：2011-07-28

申请号：US13122632

申请日：2009-10-05

Applicant: Jochen Dietz ,  Thomas Grote ,  Egon Haden ,  Bernd Muller ,  Jan Klaas Lohmann ,  Jens Renner ,  Sarah Ulmschneider ,  Alice Glattli ,  Marianna Vrettou ,  Wassillios Grammenos

Inventor： Jochen Dietz ,  Thomas Grote ,  Egon Haden ,  Bernd Muller ,  Jan Klaas Lohmann ,  Jens Renner ,  Sarah Ulmschneider ,  Alice Glattli ,  Marianna Vrettou ,  Wassillios Grammenos

IPC: A01N25/26 ,  C07D249/12 ,  A01N43/653 ,  A01P13/00 ,  A01P3/00 ,  A01P7/04

CPC classification number: C07D249/12

Abstract: Compounds of the formula I in which the variables have the meanings given in the claims and/or in the description; and their agriculturally acceptable salts.

Abstract translation: 其中变量具有权利要求和/或说明书中给出的含义的式I化合物; 及其农业上可接受的盐。

公开(公告)号：US20090069180A1

公开(公告)日：2009-03-12

申请号：US12279298

申请日：2007-02-07

Applicant: Joachim Rheinheimer ,  Thomas Grote ,  Bernd Muller ,  Wassilios Grammenos ,  Sarah Ulmschneider ,  Jens Renner ,  Reinhard Stierl

Inventor： Joachim Rheinheimer ,  Thomas Grote ,  Bernd Muller ,  Wassilios Grammenos ,  Sarah Ulmschneider ,  Jens Renner ,  Reinhard Stierl

IPC: A01N25/26 ,  A01N43/54 ,  C07D403/02

CPC classification number: C07D239/42

Abstract: The present invention relates to the use of 2-substituted pyrimidines of the formula I in which the substituents have the meanings as defined in the description, as fungicides, to novel pyrimidines, to processes and intermediates for producing them, and to compositions comprising them.

Abstract translation: 本发明涉及式I的2-取代嘧啶，其中取代基具有如本说明书中所定义的含义，作为杀真菌剂，新颖的嘧啶，其制备方法和中间体，以及包含它们的组合物。

公开(公告)号：US20090036509A1

公开(公告)日：2009-02-05

申请号：US11628324

申请日：2005-06-11

Applicant: Markus Gewehr ,  Bernd Muller ,  Thomas Grote ,  Wassilios Grammenos ,  Anja Schwogler ,  Joachim Rheinheimer ,  Carsten Blettner ,  Peter Schafer ,  Frank Schieweck ,  Oliver Wagner ,  Frank Werner ,  Jan Rether ,  Siegfried Strathmann ,  Reinhard Stierl ,  Maria Scherer

Inventor： Markus Gewehr ,  Bernd Muller ,  Thomas Grote ,  Wassilios Grammenos ,  Anja Schwogler ,  Joachim Rheinheimer ,  Carsten Blettner ,  Peter Schafer ,  Frank Schieweck ,  Oliver Wagner ,  Frank Werner ,  Jan Rether ,  Siegfried Strathmann ,  Reinhard Stierl ,  Maria Scherer

IPC: A01N43/56 ,  C07D231/14 ,  A01P3/00

CPC classification number: C07D231/14

Abstract: The present invention relates to N-(ortho-phenyl)-1-methyl-3-trifluoromethylpyrazole-4-carboxanilides of the formula I in which the substituents are as defined below: R1 and R2 independently of one another are halogen, C1-C6-alkyl, C1-C6-haloalkyl, cyano, nitro, methoxy, trifluoromethoxy or difluoromethoxy; with the proviso that when R2 is chlorine in position 4, R1 is not trifluoromethyl in position 3.

Abstract translation: 本发明涉及式I的N-（邻 - 苯基）-1-甲基-3-三氟甲基吡唑-4-甲酰苯胺，其中取代基如下所定义：R 1和R 2彼此独立地为卤素，C 1 -C 6 烷基，C 1 -C 6卤代烷基，氰基，硝基，甲氧基，三氟甲氧基或二氟甲氧基; 条件是当R2在4位是氯时，R1不在3位是三氟甲基。

公开(公告)号：US20080207455A1

公开(公告)日：2008-08-28

申请号：US11885360

申请日：2006-03-01

Applicant: Peter Schafer ,  Udo Hunger ,  Maria Scherer ,  Harald Kohle ,  Helmut Schiffer ,  Thomas Grote ,  Jochen Dietz ,  Wassilios Grammenos ,  Jan Klaas Lohmann ,  Bernd Muller ,  Joachim Rheinheimer ,  Frank Schieweck ,  Anja Schwogler

Inventor： Peter Schafer ,  Udo Hunger ,  Maria Scherer ,  Harald Kohle ,  Helmut Schiffer ,  Thomas Grote ,  Jochen Dietz ,  Wassilios Grammenos ,  Jan Klaas Lohmann ,  Bernd Muller ,  Joachim Rheinheimer ,  Frank Schieweck ,  Anja Schwogler

IPC: A01N43/50 ,  C07D487/04 ,  A01P3/00

CPC classification number: C07D487/04

Abstract: 5,6-Dialkyl-7-aminoazolopyrimidines of the formula I in which the substituents are as defined below: R1 is alkyl or alkoxyalkyl, where the aliphatic groups may be substituted as defined in the description; R2 is CHRxCH3, cyclopropyl, CH═CH2 or CH2CH═CH2; Rx is hydrogen, CH3 or CH2CH3 or halomethyl; A is N or CH; R3 is methyl, and, if A is CH, additionally hydrogen; processes and intermediates for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi. 5,6-Dialkyl-7aminoazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds

Abstract translation: 其中取代基如下定义的式I的5,6-二烷基-7-氨基偶氮嘧啶：R 1是烷基或烷氧基烷基，其中脂族基团可以如说明书中所定义的取代; R 2是CHR x CH 3，环丙基，CH-CH 2或CH 2， CH 2 CH 2; R x是氢，CH 3或CH 2 CH 3或卤代甲基; A是N或CH; R 3是甲基，并且如果A是CH，另外是氢; 制备这些化合物的方法和中间体，包含它们的组合物及其用于控制​​植物病原性有害真菌的用途。 5,6-二烷基-7氨基偶氮嘧啶，它们的制备及其用于控制​​有害真菌的用途，以及包含这些化合物的组合物

公开(公告)号：US20080171774A1

公开(公告)日：2008-07-17

申请号：US11885990

申请日：2006-03-15

Applicant: Markus Gewehr ,  Jochen Dietz ,  Thomas Grote ,  Carsten Blettner ,  Wassilios Grammenos ,  Udo Hunger ,  Bernd Muller ,  Frank Schieweck ,  Anja Schwogler ,  Jan Klaas Lohmann ,  Joachim Rheinheimer ,  Peter Schafer ,  Siegfried Strathmann ,  Reinhard Stierl ,  Jan Rether ,  Karl Eicken

Inventor： Markus Gewehr ,  Jochen Dietz ,  Thomas Grote ,  Carsten Blettner ,  Wassilios Grammenos ,  Udo Hunger ,  Bernd Muller ,  Frank Schieweck ,  Anja Schwogler ,  Jan Klaas Lohmann ,  Joachim Rheinheimer ,  Peter Schafer ,  Siegfried Strathmann ,  Reinhard Stierl ,  Jan Rether ,  Karl Eicken

IPC: C07D213/63 ,  C07D213/56 ,  A61K31/4415 ,  A61K31/455

CPC classification number: C07D213/82

Abstract: The present invention relates to nicotinanilides of the formula I in which: n=0, 1, 2; m=2, 3; X1=F, chlorine; X2=halogen; Y=CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, methoxy or methylthio; p=0, 1; R1=halogen, methyl, C1-C4-haloalkyl, methoxy, methylthio, methylsulfinyl or methylsulfonyl; R2=hydrogen, methyl or ethyl; W=O, S; processes for preparing these compounds, compositions and seed comprising them and also methods for controlling harmful fungi.

Abstract translation: 本发明涉及式I的烟酰苯胺，其中：n = 0,1,2; m = 2，3; X 1 = F，氯; X 2 =卤素; Y = CN，NO 2，C 1 -C 4 - 烷基，C 1 -C 3 - 4 - 卤代烷基，甲氧基或甲硫基; p = 0,1， R 1 =卤素，甲基，C 1 -C 4 - 卤代烷基，甲氧基，甲硫基，甲基亚磺酰基或甲基磺酰基; R 2 =氢，甲基或乙基; W = O，S; 制备这些化合物的方法，包含它们的组合物和种子以及控制有害真菌的方法。

公开(公告)号：US20080076785A1

公开(公告)日：2008-03-27

申请号：US11663982

申请日：2005-09-27

Applicant: Carsten Blettner ,  Jordi Tormo i Blasco ,  Bernd Muller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler ,  Oliver Wagner ,  John-Bryan Speakman ,  Thorsten Jabs ,  Siegfried Strathmann ,  Ulrich Schofl ,  Maria Scherer ,  Reinhard Stierl

Inventor： Carsten Blettner ,  Jordi Tormo i Blasco ,  Bernd Muller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler ,  Oliver Wagner ,  John-Bryan Speakman ,  Thorsten Jabs ,  Siegfried Strathmann ,  Ulrich Schofl ,  Maria Scherer ,  Reinhard Stierl

IPC: A01N43/54 ,  A01P3/00 ,  C07D239/70

CPC classification number: A01N43/90 ,  C07D487/04

Abstract: The invention relates to 7-aminomethyl-1,2,4-triazolo[1,5-a]pyrimidine compounds of general formula (I) and the agriculturally compatible salts of said compounds. In said formula: R1 and R2 represent hydrogen, alkyl, haloalkyl, alkoxy, cycloalkyl, bicycloalkyl, halocycloalkyl, alkenyl, alkadienyl, haloalkenyl, cycloalkenyl, halocycloalkenyl, alkynyl, haloalkynyl or phenyl, naphthyl, or a 5- or 6-membered saturated, partially unsaturated or aromatic heterocycle, containing 1 to 4 heteroatoms from the group containing O, N or S, or R1 and R2, together with the nitrogen atom to which they are bonded, can also form a five- or six-membered heterocyclyl or heteroaryl, which is bonded by means of N and can contain 1 to 3 additional heteroatoms from the group containing O, N and S as the ring member and can be substituted according to the description; R3 and R4 represent hydrogen, alkyl, haloalkyl, haloalkoxy, alkoxy, or alkoxyalkyl; X represents halogen, cyano, a 5- or 6-membered saturated, partially unsaturated or aromatic heterocycle, containing 1, 2 or 3 heteroatoms from the group containing O, N or S as the ring member, alkyl, alkoxy, alkenyl or alkynyl, whereby the latter 4 groups can be substituted according to the description; L is defined as cited in the claims and the description; and m represents 0, 1, 2, 3, 4 or 5. The invention also relates to the use of the triazolopyrimidine compounds of general formula (I) and their agriculturally compatible salts for controlling plant-pathogenic fungi, to a method for controlling plant-pathogenic fungi, containing at least one compound of general formula (I) and/or an agriculturally compatible salt of said compound and at least one liquid or solid carrier.

Abstract translation: 本发明涉及通式（I）的7-氨基甲基-1,2,4-三唑并[1,5-a]嘧啶化合物和所述化合物的农业上相容的盐。 在所述式中：R 1和R 2表示氢，烷基，卤代烷基，烷氧基，环烷基，二环烷基，卤代环烷基，烯基，链烯基，卤代烯基，环烯基，卤代环烯基，炔基，卤代炔基或苯基，萘基或5-或6-元饱和， 部分不饱和或芳族杂环，含有1至4个含有O，N或S的杂原子，或R 1和R 2与它们所键合的氮原子一起也可以形成五元或六元杂环基或杂芳基 ，其通过N键合并且可以含有来自含有O，N和S的基团的1至3个另外的杂原子作为环成员，并且可以根据描述进行取代; R3和R4代表氢，烷基，卤代烷基，卤代烷氧基，烷氧基或烷氧基烷基; X代表卤素，氰基，含有1,2或3个杂原子的5-或6-元饱和的部分不饱和或芳族杂环，所述杂环含有作为环成员的O，N或S，烷基，烷氧基，烯基或炔基， 由此后4个组可以根据描述被替代; L定义为权利要求书和说明书中引用的; 和m表示0,1,2,3,4或5.本发明还涉及通式（I）的三唑并嘧啶化合物及其农业上相容的盐用于控制植物致病真菌的用途，用于控制植物的方法 致病真菌，含有至少一种通式（I）的化合物和/或所述化合物的农业上相容的盐和至少一种液体或固体载体。

公开(公告)号：US20070270311A1

公开(公告)日：2007-11-22

申请号：US11661566

申请日：2005-09-02

Applicant: Carsten Blettner ,  Jordi Blasco ,  Bernd Muller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler ,  Jochen Dietz ,  John-Bryan Speakman ,  Thorsten Jabs ,  Siegfried Strathmann ,  Ulrich Schofl ,  Maria Scherer ,  Reinhard Stierl

Inventor： Carsten Blettner ,  Jordi Blasco ,  Bernd Muller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler ,  Jochen Dietz ,  John-Bryan Speakman ,  Thorsten Jabs ,  Siegfried Strathmann ,  Ulrich Schofl ,  Maria Scherer ,  Reinhard Stierl

IPC: A01N43/90 ,  A01P3/00 ,  C07D487/02

CPC classification number: A01N43/90 ,  A01N47/06 ,  A01N47/12 ,  A01N47/16 ,  C07D487/04

Abstract: 6-Phenyl-7-aminotriazolopyrimidines of the formula I in which the substituents are as defined below: R1 is hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, cycloalkenyl, halocycloalkenyl, alkynyl, haloalkynyl or phenyl, naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle, which comprises one to four heteroatoms from the group consisting of O, N and S, R2 is alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, cycloalkenyl, halocycloalkenyl, alkynyl, haloalkynyl or phenyl, naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle which comprises one to four heteroatoms from the group consisting of O, N and S, R3,R4,R5,R6,R7 are hydrogen or one of the groups mentioned under R2, R4, together with R3 or R6, may also form a five- or six-membered saturated or unsaturated ring which, in addition to carbon atoms, may comprise one to three further heteroatoms from the group consisting of O, N and S as ring members; R2 with R3, R4 with R5, R6 with R7 may in each case together, with formation of spiro groups, also form a C2-C5-alkylene, or alkenylene or alkynylene chain which may be interrupted by one to three heteroatoms from the group consisting of O, N and S; p is zero or 1; L is halogen, alkyl, haloalkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, alkylcarbonylamino, C(O)—R, S(O)n—R; where n is zero, 1 or 2; R is hydrogen, alkyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, amino, alkylamino, dialkylamino; m is 1, 2, 3, 4 or 5; X is halogen, cyano, alkyl, alkoxy, alkenyloxy, alkynyloxy or haloalkoxy; Y is oxygen or sulfur; Z is hydrogen, alkyl, haloalkyl, cycloalkyl, alkylcarbonyl, cycloalkylcarbonyl, alkenyl, haloalkenyl, cycloalkenyl, alkynyl, haloalkynyl, phenyl, naphthyl, a five- to ten-membered saturated, partially unsaturated or aromatic heterocycle which comprises one to four heteroatoms from the group consisting of O, N and S; or Z together with R4 or R6 may also form a five- or six-membered saturated or unsaturated ring which, in addition to carbon atoms and Y, may comprise one or two further heteroatoms from the group consisting of O, N and S as ring members the groups R1 to R7, Z and R may be substituted according to the description; processes for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi.

公开(公告)号：US20070105928A1

公开(公告)日：2007-05-10

申请号：US10582938

申请日：2004-12-14

Applicant: Jordi Tormo I Blasco ,  Carsten Blettner ,  Bernd Muller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler ,  Oliver Wagner ,  Maria Scherer ,  Siegfried Strathmann ,  Ulrich Schofl ,  Reinhard Stierl

Inventor： Jordi Tormo I Blasco ,  Carsten Blettner ,  Bernd Muller ,  Markus Gewehr ,  Wassilios Grammenos ,  Thomas Grote ,  Joachim Rheinheimer ,  Peter Schafer ,  Frank Schieweck ,  Anja Schwogler ,  Oliver Wagner ,  Maria Scherer ,  Siegfried Strathmann ,  Ulrich Schofl ,  Reinhard Stierl

IPC: A61K31/41

CPC classification number: F02B43/04 ,  F02B19/14 ,  F02B43/10 ,  F02M25/10 ,  Y02T10/121 ,  Y02T10/125 ,  Y02T10/32

Abstract: 6-Pentafluorophenyltriazolopyrimidines of the formula I in which the substituents are as defined below: R1 is alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, cycloalkenyl, halocycloalkenyl, alkinyl, haloalkinyl or phenyl, naphthyl, or a five- or six-membered saturated, partially unsaturated or aromatic heterocycle which contains one to four heteroatoms from the group consisting of O, N and S, R2 is hydrogen or one of the groups mentioned under R1, R1 and R2 together with the nitrogen atom to which they are attached may also form a five- or six-membered heterocyclyl or heteroaryl which is attached via N and may contain one to three further heteroatoms from the group consisting of O, N and S as ring members; R1 and/or R2 may be substituted as defined in the description; X is cyano, alkyl, alkoxy, alkenyloxy, haloalkoxy or haloalkenyloxy, processes for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi.

Abstract translation: 式I的6-五氟苯基三唑并嘧啶，其中取代基如下：R 1是烷基，卤代烷基，环烷基，卤代环烷基，烯基，卤代烯基，环烯基，卤代环烯基，炔基，卤代炔基或苯基，萘基， 或五元或六元饱和，部分不饱和或芳族杂环，其含有一至四个由O，N和S组成的组的杂原子，R 2是氢或下述基团之一 R 1，R 1和R 2与它们所连接的氮原子一起也可以形成五元或六元杂环基 或杂芳基，其通过N连接并且可以含有一个至三个由O，N和S组成的组的另外的杂原子作为环成员; R 1和/或R 2可以如说明书中所定义的取代; X是氰基，烷基，烷氧基，烯氧基，卤代烷氧基或卤代烯氧基，制备这些化合物的方法，包含它们的组合物及其用于控制​​植物病原性有害真菌的用途。