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    AROMATIC SUBSTITUTED ETHANE-CORE MONOMERS AND POLYMERS THEREOF FOR VOLUME BRAGG GRATINGS
    2.
    发明申请
    AROMATIC SUBSTITUTED ETHANE-CORE MONOMERS AND POLYMERS THEREOF FOR VOLUME BRAGG GRATINGS 有权

    公开(公告)号：US20210155581A1

    公开(公告)日：2021-05-27

    申请号：US17098187

    申请日：2020-11-13

    申请人： Facebook Technologies, LLC

    发明人： Lafe PURVIS ,  Austin LANE ,  Matthew E. COLBURN

    IPC分类号： C07C271/54 ,  G03H1/02

    摘要： The disclosure provides recording materials including aromatic substituted ethane-core derivatized monomers and polymers for use in volume Bragg gratings, including, but not limited to, volume Bragg gratings for holography applications. Several structures are disclosed for monomers and polymers for use in Bragg gratings applications, leading to materials with higher refractive index, low birefringence, and high transparency. The disclosed derivatized monomers and polymers thereof can be used in any volume Bragg gratings materials, including two-stage polymer materials where a matrix is cured in a first step, and then the volume Bragg grating is written by way of a second curing step of a monomer.

    AMINO ACID AND PEPTIDE CARBAMATE PRODRUGS OF TAPENTADOL AND USES THEREOF
    3.
    发明申请
    AMINO ACID AND PEPTIDE CARBAMATE PRODRUGS OF TAPENTADOL AND USES THEREOF 审中-公开
    氨基酸和肽的碳酸氢钠制剂及其用途

    公开(公告)号：US20100227921A1

    公开(公告)日：2010-09-09

    申请号：US12714828

    申请日：2010-03-01

    申请人： Richard Franklin ,  Bernard T. Golding ,  Robert G. Tyson

    发明人： Richard Franklin ,  Bernard T. Golding ,  Robert G. Tyson

    IPC分类号： A61K31/27 ,  C07C271/54 ,  A61P29/00

    CPC分类号： C07C269/02 ,  C07C271/54

    摘要： Prodrugs of tapentadol with amino acids or short peptides, pharmaceutical compositions containing such prodrugs and a method for providing pain relief with the tapentadol prodrugs are provided herein. Prodrugs having side chains of valine, leucine, isoleucine and glycine amino acids and mono-, di- and tripeptides thereof are preferred. Additionally, methods for avoiding or minimizing the adverse gastrointestinal side effects associated with tapentadol administration, as well as increasing the oral bioavailability of tapentadol are provided herein.

    摘要翻译： 提供了具有氨基酸或短肽的他喷他多的前药，含有这些前药的药物组合物以及用于给他汀类药物前体药物缓解的方法。 具有缬氨酸，亮氨酸，异亮氨酸和甘氨酸氨基酸侧链的前药优选其单 - ，二 - 和三肽。 此外，本文提供了避免或最小化与他喷他多施用相关的不利胃肠道副作用的方法，以及增加他喷他多的口服生物利用度。