知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

223 条记录 (耗时 0.047 秒)

    Taxanes compounds, preparation method therefor, and uses thereof
    2.
    发明授权
    Taxanes compounds, preparation method therefor, and uses thereof 有权

    公开(公告)号：US10253007B2

    公开(公告)日：2019-04-09

    申请号：US15038264

    申请日：2014-11-21

    申请人： Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

    发明人： Wei Zhou ,  Yunrong Jing ,  Yongfeng Wang ,  Guocheng Wang

    IPC分类号： A61K31/337 ,  C07D305/14 ,  C07D405/12 ,  C07C271/22 ,  C07C233/87

    摘要： The present invention provides taxanes compounds with a formula (I) or formula (II) structure, a method for preparing the compounds, as well as the use of the compositions containing the compounds, pharmaceutically acceptable salts and solvates thereof as active ingredients in manufacturing oral antitumor medicaments, In formula (I), R1 is —COR6, —COOR6 or —CONR7aR7b; R2 is a C1-C6 alkyl, a C1-C6 alkenyl, a substituted hydrocarbon group, a heterocyclic group, an aromatic group or a substituted aromatic group; R3 is —OR6, —OCOOR6, —OCOSR6 or —OCONR7aR7b; R4 is —OR6, —OCOOR6, —OCOSR6, —OCONR7aR7b or H; wherein, R6 is a C1-C6 alkyl, a C1-C6 alkenyl, a C1-C6 alkynyl, a substituted hydrocarbon group, an aromatic group or a heterocyclic group; R7a and R7b are respectively hydrogen, a hydrocarbon group, a substituted hydrocarbon group or a heterocyclic group. In formula (II), R1 is —COR6 or —COOR6; R2 is an aromatic group; R3 is —OR6; wherein, R6 is a C1-C6 alkyl, a C1-C6 alkenyl, a C1-C6 alkynyl, a substituted hydrocarbon group, an aromatic group or a heterocyclic group.