公开(公告)号：US07582676B2

公开(公告)日：2009-09-01

申请号：US10544361

申请日：2004-02-12

Applicant: Juan Francisco Caturla Javaloyes ,  Graham Warrellow

Inventor： Juan Francisco Caturla Javaloyes ,  Graham Warrellow

IPC: A61K31/35 ,  C07D309/38

CPC classification number: C07D309/38

Abstract: The present invention relates to 2-phenylpyran-4-derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, and their medical uses.

Abstract translation: 本发明涉及通式（I）的2-苯基吡喃-4-衍生物，其制备方法，含有它们的药物组合物及其医疗用途。

公开(公告)号：US20060229338A1

公开(公告)日：2006-10-12

申请号：US10544360

申请日：2004-02-12

Applicant: Juan Caturla Javaloyes ,  Graham Warrellow

Inventor： Juan Caturla Javaloyes ,  Graham Warrellow

IPC: A61K31/444 ,  C07D401/04

CPC classification number: C07D213/61

Abstract: The present invention relates to 2,3′-bipyridines of formula (I), processes for their preparation, pharmaceutical compositions containing them, and their medical uses.

Abstract translation: 本发明涉及式（I）的2,3'-联吡啶，其制备方法，含有它们的药物组合物及其医疗用途。

公开(公告)号：US20090029996A1

公开(公告)日：2009-01-29

申请号：US11629527

申请日：2005-06-21

Applicant: Nuria Aguilar Izquierdo ,  Marta Carrascal Riera ,  Vittorio Dal Piaz ,  Jordi Gracia Ferrer ,  Wenceslao Lumeras Amador ,  Maria Del Carmen Masdeu Margalef ,  Graham Warrellow

Inventor： Nuria Aguilar Izquierdo ,  Marta Carrascal Riera ,  Vittorio Dal Piaz ,  Jordi Gracia Ferrer ,  Wenceslao Lumeras Amador ,  Maria Del Carmen Masdeu Margalef ,  Graham Warrellow

IPC: A61K31/5377 ,  C07D403/02 ,  A61K31/501 ,  A61P19/02 ,  A61P1/00 ,  A61P17/00 ,  A61P11/00 ,  C07D413/14

CPC classification number: C07D405/14 ,  C07D237/24 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04 ,  C07D495/04

Abstract: The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives, to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention and suppression of related pathological conditions, diseases and disorders, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, topic dermatitis, psoriasis or irritable bowel disease.

Abstract translation: 本发明涉及新的治疗上有用的哒嗪-3（2H） - 酮衍生物，其制备方法以及含有它们的药物组合物。 这些化合物是磷酸二酯酶4（PDE4）的有效和选择性抑制剂，因此可用于治疗，预防和抑制相关病理状况，疾病和病症，特别是哮喘，慢性阻塞性肺病，类风湿性关节炎，主题皮炎，牛皮癣或 肠易激综合征

公开(公告)号：US20060142380A1

公开(公告)日：2006-06-29

申请号：US10544361

申请日：2004-02-12

Applicant: Juan Caturla Javaloyes ,  Graham Warrellow

Inventor： Juan Caturla Javaloyes ,  Graham Warrellow

IPC: A61K31/4433 ,  A61K31/381 ,  A61K31/34 ,  C07D409/02 ,  C07D405/02

CPC classification number: C07D309/38

Abstract: The present invention relates to 2-phenylpyran-4-derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, and their medical uses.

Abstract translation: 本发明涉及通式（I）的2-苯基吡喃-4-衍生物，其制备方法，含有它们的药物组合物及其医疗用途。

公开(公告)号：US20060189684A1

公开(公告)日：2006-08-24

申请号：US10544359

申请日：2004-02-12

Applicant: Juan Caturla Javaloyes ,  Graham Warrellow

Inventor： Juan Caturla Javaloyes ,  Graham Warrellow

IPC: A61K31/365 ,  C07D305/12

CPC classification number: C07D307/58

Abstract: The present invention relates to 3-phenylfuran-2-ones of formula (I), processes for their preparation, pharmaceutical compositions containing them, and their medical uses.

Abstract translation: 本发明涉及式（I）的3-苯基呋喃-2-酮，其制备方法，含有它们的药物组合物及其医疗用途。

公开(公告)号：US20070179183A1

公开(公告)日：2007-08-02

申请号：US10555286

申请日：2004-05-03

Applicant: Juan Jimenez Mayorga ,  Laura Vidal Gispert ,  Graham Warrellow

Inventor： Juan Jimenez Mayorga ,  Laura Vidal Gispert ,  Graham Warrellow

IPC: A61K31/445 ,  A61K31/195 ,  A61K31/24 ,  C07D211/06

CPC classification number: C07D213/81 ,  C07C307/06 ,  C07D295/26 ,  C07D333/20 ,  C07D409/12 ,  C07D471/04

Abstract: Compounds of the following formula and salts thereof are described as integrin α4-antagonists, wherein the various symbols are as defined in the specification.

Abstract translation: 下列化学式及其盐的化合物被描述为整联蛋白α4拮抗剂，其中各种符号如说明书中所定义。

公开(公告)号：US20050215598A1

公开(公告)日：2005-09-29

申请号：US11130531

申请日：2005-05-17

Applicant: Sarah Archibald ,  John Head ,  Graham Warrellow ,  John Porter

Inventor： Sarah Archibald ,  John Head ,  Graham Warrellow ,  John Porter

IPC: A61K31/195 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/455 ,  A61P29/00 ,  A61P37/02 ,  A61P43/00 ,  C07C233/87 ,  C07C235/60 ,  C07C237/30 ,  C07C323/62 ,  C07D213/61 ,  C07D213/81 ,  C07D403/12 ,  C07D213/46 ,  C07D43/02

CPC classification number: C07D213/81 ,  C07C233/87 ,  C07C235/60 ,  C07C237/30 ,  C07C323/62 ,  C07D213/61

Abstract: Phenylalanine derivatives of formula (1) are described: wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; Ar is an optionally substituted aromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

Abstract translation: 描述了式（1）的苯丙氨酸衍生物：其中R是羧酸或其衍生物; L 1是连接原子或基团; Ar是任选取代的芳族基团; 及其盐，溶剂合物，水合物和N-氧化物。 该化合物能够抑制α4整联蛋白与其配体的结合，并且可用于预防和治疗免疫或炎症性疾病。