公开(公告)号：US20240245778A1

公开(公告)日：2024-07-25

申请号：US18594194

申请日：2024-03-04

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin MAIER ,  Muthusamy JAYARAMAN ,  Akin AKINC ,  Shigeo MATSUDA ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN ,  Jayaprakash K. NAIR ,  Thomas A. BAILLIE

IPC: A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/02

CPC classification number: A61K47/18 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C07C31/125 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C235/06 ,  C07C251/38 ,  C07C323/12 ,  C07C323/58 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07D207/32 ,  C07D233/54 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07D317/30 ,  C07F5/022

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US11833129B2

公开(公告)日：2023-12-05

申请号：US17149549

申请日：2021-01-14

Applicant: Avoscience, LLC

Inventor： Samuel Richard Huber

IPC: A61K31/341 ,  C07D307/36 ,  A61K45/06 ,  C07D333/10 ,  A61K31/381 ,  C07D207/32 ,  A61K31/40 ,  A61K31/443

CPC classification number: A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K45/06 ,  C07D207/32 ,  C07D307/36 ,  C07D333/10 ,  A61K31/443

Abstract: Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective amount of a compound of Formula I, II, or III, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from a cancer, neurological disorder, or fibrotic disorder.

公开(公告)号：US11590229B2

公开(公告)日：2023-02-28

申请号：US17651029

申请日：2022-02-14

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC: A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20220175929A1

公开(公告)日：2022-06-09

申请号：US17651029

申请日：2022-02-14

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC: A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US20220112138A1

公开(公告)日：2022-04-14

申请号：US17424220

申请日：2020-01-02

Applicant: The Hong Kong University of Science and Technology

Inventor： Jianwei Sun ,  Xingguang LI

IPC: C07B53/00 ,  C07D207/32 ,  C07D417/06 ,  C07D409/06 ,  C07D209/08 ,  C07D403/06 ,  C07D413/14 ,  C07D417/14 ,  B01J31/02

Abstract: Provided herein are enantioselective organocatalytic methods for preparing chiral tetraaryl methanes.

公开(公告)号：US20220111053A1

公开(公告)日：2022-04-14

申请号：US17644914

申请日：2021-12-17

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： MARTIN MAIER ,  MUTHUSAMY JAYARAMAN ,  AKIN AKINC ,  SHIGEO MATSUDA ,  PACHAMUTHU KANDASAMY ,  KALLANTHOTTATHIL G. RAJEEV ,  MUTHIAH MANOHARAN

IPC: A61K47/18 ,  C07C211/10 ,  C07D295/08 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  C07C31/125 ,  C07D317/30 ,  A61K31/713 ,  C07C229/12 ,  C07C323/12 ,  C07C323/58 ,  C07C211/09 ,  A61K31/7105 ,  C07C235/06 ,  C07C327/32 ,  C07D295/12 ,  C07C251/38 ,  C07C327/22 ,  C07F5/02 ,  C07C211/11 ,  C07C327/28 ,  C07D207/32 ,  C07D233/54 ,  C07C217/08 ,  C07D295/14

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US11246933B1

公开(公告)日：2022-02-15

申请号：US17302311

申请日：2021-04-29

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Martin Maier ,  Muthusamy Jayaraman ,  Akin Akinc ,  Shigeo Matsuda ,  Pachamuthu Kandasamy ,  Kallanthottathil G. Rajeev ,  Muthiah Manoharan

IPC: A61K47/18 ,  A61K48/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US10889544B2

公开(公告)日：2021-01-12

申请号：US16121239

申请日：2018-09-04

Applicant: UNIVERSITY OF NOTRE DAME DU LAC

Inventor： William F. Schneider ,  Joan F. Brennecke ,  Edward J. Maginn ,  Elaine Vazquez ,  Burcu Gurkan ,  Erica Price ,  Brett Goodrich

IPC: B01D53/02 ,  C07D207/32 ,  B01D53/14 ,  C07D207/323 ,  C07D207/325 ,  C07D207/33 ,  C07D207/34 ,  C07D207/46 ,  C07D209/08 ,  C07D231/12 ,  C07D233/58 ,  C07F9/54

Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.

公开(公告)号：US10759765B2

公开(公告)日：2020-09-01

申请号：US16093688

申请日：2017-04-14

Applicant: CE Pharm CO., LTD.

Inventor： Dawei Ma ,  Wei Zhou ,  Mengyang Fan ,  Haibo Wu ,  Junli Yin ,  Xi Jiang ,  Yuntong Zhai ,  Songtao Niu

IPC: C07D241/02 ,  B01J31/22 ,  C07C231/02 ,  C07C233/00 ,  C07D207/32 ,  C07D209/08 ,  C07D209/12 ,  C07D213/06 ,  C07D235/08 ,  C07D239/02 ,  C07D277/02 ,  C07D277/62 ,  C07D307/02 ,  C07D307/78 ,  C07C209/60

Abstract: Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

公开(公告)号：US20190389797A1

公开(公告)日：2019-12-26

申请号：US16553718

申请日：2019-08-28

Applicant: Cadila Healthcare Limited

Inventor： Shriprakash Dhar Dwivedi ,  Ramesh Chandra Singh ,  Rajendra Gokalbhai Chavda ,  Jagdish Maganlal Patel ,  Daya Ram Pal ,  Pranav Jitendra Gangwar ,  Vikas Patel ,  Vishwadeepak Rama Pati Tripathi

IPC: C07D207/333 ,  C07D207/32

Abstract: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.