公开(公告)号：US10889544B2

公开(公告)日：2021-01-12

申请号：US16121239

申请日：2018-09-04

Applicant: UNIVERSITY OF NOTRE DAME DU LAC

Inventor： William F. Schneider ,  Joan F. Brennecke ,  Edward J. Maginn ,  Elaine Vazquez ,  Burcu Gurkan ,  Erica Price ,  Brett Goodrich

IPC: B01D53/02 ,  C07D207/32 ,  B01D53/14 ,  C07D207/323 ,  C07D207/325 ,  C07D207/33 ,  C07D207/34 ,  C07D207/46 ,  C07D209/08 ,  C07D231/12 ,  C07D233/58 ,  C07F9/54

Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.

公开(公告)号：US20200223845A1

公开(公告)日：2020-07-16

申请号：US16798859

申请日：2020-02-24

Applicant: Katholieke Universiteit Leuven

Inventor： Dorothée Bardiot ,  Gunter Carlens ,  Kai Dallmeier ,  Suzanne Kaptein ,  Mohamed Koukni ,  Arnaud Marchand ,  Johan Neyts ,  Wim Smets

IPC: C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D223/04 ,  C07D231/12 ,  C07D333/22 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D261/08 ,  C07D207/06 ,  C07D265/30 ,  C07D267/10 ,  C07D275/02 ,  C07D498/04 ,  C07D279/12 ,  A61K31/415 ,  C07D409/12 ,  A61K31/34 ,  A61K31/381 ,  A61K31/40 ,  C07D207/323 ,  C07D403/06 ,  C07D405/12 ,  C07D407/06 ,  C07D271/04 ,  C07D285/06 ,  A61K31/4439 ,  C07D403/12 ,  C07D243/06 ,  A61K31/437 ,  C07D211/06 ,  A61K45/06 ,  C07D513/04 ,  C07D407/04 ,  C07D307/46 ,  C07D207/335 ,  C07D211/16 ,  C07D241/04 ,  C07D243/08 ,  C07D263/32 ,  C07D271/08 ,  C07D277/28 ,  C07D285/10 ,  C07D307/52 ,  C07D413/12 ,  C07D487/04

Abstract: The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

公开(公告)号：US20200223797A1

公开(公告)日：2020-07-16

申请号：US16347117

申请日：2017-11-09

Applicant: PIRELLI TYRE S.p.A ,  POLITECNICO DI MILANO

Inventor： Maurizio Stefano GALIMBERTI ,  Vincenzina BARBERA

IPC: C07D207/323 ,  C07D207/333

Abstract: Adducts are described, obtainable from the reaction product of a secondary amine and a diketone, with carbon allotropes in which the carbon is sp2 hybridized, such as graphene, graphite, fullerene, carbon nanotubes and the like, and an inorganic oxide-hy-droxide. A process for preparing said adducts is also described.

公开(公告)号：US20190194386A1

公开(公告)日：2019-06-27

申请号：US16330833

申请日：2017-09-08

Applicant: Auckland UniServices Limited

Inventor： Jadranka Travas-Sejdic ,  David Edward Williams ,  Nihan Aydemir ,  David Barker ,  Wai Chi Eddie Chan ,  Clive William Evans

IPC: C08G61/12 ,  C07D207/323 ,  C07D333/08 ,  C12Q1/6844 ,  B01L7/00 ,  C12Q1/6862 ,  C07D333/16 ,  C07D207/333 ,  G01N27/327

CPC classification number: C08G61/126 ,  B01L7/52 ,  B01L2300/0645 ,  B01L2300/0663 ,  C07D207/323 ,  C07D207/333 ,  C07D333/08 ,  C07D333/16 ,  C08G61/124 ,  C08G2261/12 ,  C08G2261/1424 ,  C08G2261/1426 ,  C08G2261/1432 ,  C08G2261/1452 ,  C08G2261/312 ,  C08G2261/3221 ,  C08G2261/3223 ,  C08G2261/44 ,  C08G2261/94 ,  C12Q1/6844 ,  C12Q1/6862 ,  C25D9/02 ,  G01N27/3277

Abstract: The present invention generally relates to the field of conducting polymers. More specifically, the present invention relates to polymerisable monomers comprising a probe capable of binding one or more nucleic acids or comprising a nucleic acid or an analogue thereof, conducting polymers comprising monomer units of such monomers, and methods of making such polymers. The present invention also relates to sensors comprising the polymers, sensor systems comprising the sensors, methods of making the sensors, and methods for determining the presence or absence or amount of targets employing the sensors. The present invention also relates to methods, systems and apparatuses for amplifying nucleic acids employing the conducting polymers.

公开(公告)号：US10259788B2

公开(公告)日：2019-04-16

申请号：US15802360

申请日：2017-11-02

Applicant: UNIVERSITY OF NOTRE DAME DU LAC

Inventor： William F. Schneider ,  Joan F. Brennecke ,  Edward J. Maginn ,  Elaine Vazquez ,  Burcu Gurkan ,  Erica Price ,  Brett Goodrich

IPC: B01D53/02 ,  C07D207/32 ,  B01D53/14 ,  C07D207/323 ,  C07D207/325 ,  C07D207/33 ,  C07D207/34 ,  C07D207/46 ,  C07D209/08 ,  C07D231/12 ,  C07D233/58 ,  C07F9/54

Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.

公开(公告)号：US20170158695A1

公开(公告)日：2017-06-08

申请号：US15310295

申请日：2015-06-04

Applicant: Lonza Ltd

Inventor： Christoph Taeschler ,  Matthias Beller ,  Helfried Neumann ,  Lin He ,  Kishore Natte ,  Stefan Ellinger ,  Florencio Zaragoza Doerwald

IPC: C07D473/12 ,  C07D333/12 ,  C07D333/28 ,  C07C22/08 ,  C07D213/26 ,  C07B37/04 ,  C07C17/32 ,  C07D207/323 ,  C07D213/127

CPC classification number: C07D473/12 ,  C07B37/04 ,  C07C17/32 ,  C07C22/08 ,  C07C41/30 ,  C07C45/68 ,  C07C253/30 ,  C07D207/323 ,  C07D213/127 ,  C07D213/26 ,  C07D333/12 ,  C07D333/28 ,  C08F8/24 ,  C07C25/02 ,  C07C255/54 ,  C07C43/225 ,  C07C43/23 ,  C07C49/84 ,  C08F12/08

Abstract: The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs2C03 or CsHC03.

公开(公告)号：US09637384B2

公开(公告)日：2017-05-02

申请号：US14799568

申请日：2015-07-14

Applicant: Nano and Advanced Materials Institute Limited

Inventor： Wing Leung Wong ,  Lai To Leung ,  Liang Zhang ,  Chi Mei Chow ,  Haojun Zhu ,  Lai Fan Lai ,  Kwok Keung Paul Ho

IPC: C07F7/08 ,  C07F7/18 ,  C01B31/02 ,  H01L51/42 ,  C07D295/033 ,  C07D207/323 ,  C07D209/18 ,  H01L51/00 ,  C07C2/86 ,  C07C29/48 ,  C07C67/05

CPC classification number: C01B31/0213 ,  C01B32/152 ,  C07C2/86 ,  C07C29/48 ,  C07C67/05 ,  C07C2604/00 ,  C07D207/323 ,  C07D209/18 ,  C07D295/033 ,  C07F7/081 ,  C07F7/1804 ,  H01L51/0047 ,  H01L51/0094 ,  H01L51/42 ,  C07C13/62 ,  C07C69/76 ,  C07C35/44

Abstract: The present invention relates to new fullerene derivatives of formulae 1a-d, 2 and 3: method of synthesizing said derivatives, and applications thereof in organic photovoltaics, e.g., organic solar cells. In particular, the fullerene derivatives of the present invention are soluble in non-halogenated solvents such that an environmental-friendly and low-cost fabrication method for industrialization of solar cell based on the new fullerene derivatives is provided. An ink formulation for forming a thin film on a substrate of organic photovoltaics comprising at least one of the fullerene derivatives of the present invention is also provided. Greater than 3% power conversion efficiency of the organic solar cells (area=0.16 cm2) formed based on the fullerene derivatives of the present invention with less pollution and lower cost in fabrication can be achieved in the present invention.

公开(公告)号：US09302988B2

公开(公告)日：2016-04-05

申请号：US14013081

申请日：2013-08-29

Applicant: GRÜNENTHAL GMBH

Inventor： Stefan Schunk ,  Melanie Reich ,  Henning Steinhagen ,  Nils Damann ,  Michael Haurand ,  Achim Kless ,  Philip Skone ,  Richard Hamlyn ,  Robert Kirby ,  Marc Rogers ,  Kathy Sutton

IPC: C07D207/323 ,  C07D207/34 ,  C07D403/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

CPC classification number: C07D207/34 ,  C07D207/323 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract translation: 本发明涉及带有氟甲基部分作为电压门控钙通道阻断剂的吡咯甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或障碍的这些化合物。

公开(公告)号：US09227935B2

公开(公告)日：2016-01-05

申请号：US14561252

申请日：2014-12-05

Applicant: Janssen Pharmaceutica N.V.

Inventor： Jean-Pierre Andre Marc Bongartz ,  Joannes Theodorus Maria Linders ,  Lieven Meerpoel ,  Guy Rosalia Eugeen Van Lommen ,  Erwin Coesemans ,  Mirielle Braeken ,  Christophe Francis Robert Nestor Buyck ,  Monique Jenny Marie Berwaer ,  Katharina Antonia Germania J. M. De Waepenaert ,  Peter Walter Maria Roevens ,  Petr Vladimirivich Davidenko

IPC: A61K31/451 ,  C07D401/12 ,  C07D211/60 ,  A61K31/495 ,  C07D207/323 ,  C07D211/26 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D257/04 ,  C07D263/34 ,  C07D277/56 ,  C07D279/02 ,  C07D279/12 ,  C07D295/20 ,  C07D307/54 ,  C07D319/18 ,  C07D417/12 ,  C07D417/14 ,  C07D207/277 ,  C07D295/205 ,  C07D295/21 ,  C07D295/215

CPC classification number: A61K31/4523 ,  A61K31/451 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  C07D207/277 ,  C07D207/323 ,  C07D211/26 ,  C07D211/60 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D257/04 ,  C07D263/34 ,  C07D277/56 ,  C07D279/02 ,  C07D279/12 ,  C07D295/20 ,  C07D295/205 ,  C07D295/21 ,  C07D295/215 ,  C07D307/54 ,  C07D319/18 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: The invention relates to a DGAT inhibitor of formula including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —O—C(═O)—; —C(═O)—C(═O)—; —NRx—C(═O)—; —Z—C(═O)—; —Z—NRx—C(═O)—; —C(═O)—Z—; —NRx—C(═O)—Z—; —C(═S)—; —NRx—C(═S)—; —Z—C(═S)—; —Z—NRx—C(═S)—; —C(═S)—Z—; —NRx—C(═S)—Z—; Z represents a bivalent radical selected from C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl; wherein each of said C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl may optionally be substituted; and wherein two hydrogen atoms attached to the same carbon atom in C1-6alkanediyl may optionally be replaced by C1-6alkanediyl; Y represents —C(═O)—NRx— or —NRx—C(═O)—; R1 represents adamantanyl, C3-6cycloalkyl; aryl1 or Het1; R2 represents C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl or heterocycle may optionally be substituted; R7 represents hydrogen, halo, C1-4alkyl, C1-4alkyl substituted with hydroxyl; provided that the following compounds are excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine, as a DGAT inhibitor, of said compounds.

公开(公告)号：US20140128408A1

公开(公告)日：2014-05-08

申请号：US13985760

申请日：2012-01-31

Applicant: Alan Kozikowski ,  Jay H. Kalin ,  Kyle V. Butier ,  Joel Bergman ,  Wayne W. Hancock

Inventor： Alan Kozikowski ,  Jay H. Kalin ,  Kyle V. Butier ,  Joel Bergman ,  Wayne W. Hancock

IPC: C07C229/52 ,  A61K31/404 ,  A61K51/04 ,  A61K45/06 ,  C07D473/00 ,  A61K31/52 ,  C07D209/14 ,  A61K31/496 ,  C07D235/06 ,  A61K31/4184 ,  C07D207/323 ,  A61K31/402 ,  C07D231/12 ,  A61K31/415 ,  C07D213/56 ,  A61K31/4409 ,  A61K31/24 ,  C07C259/10 ,  A61K31/166 ,  C07D209/08

CPC classification number: C07C229/52 ,  A61K45/06 ,  A61K49/0002 ,  A61K51/04 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  C07C259/10 ,  C07C2601/08 ,  C07D207/08 ,  C07D207/323 ,  C07D209/08 ,  C07D209/14 ,  C07D209/18 ,  C07D209/20 ,  C07D213/56 ,  C07D231/12 ,  C07D235/06 ,  C07D473/00

Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

Abstract translation: 公开了组蛋白脱乙酰酶抑制剂（HDACI）和包含其的组合物。 治疗疾病和病症的方法，其中HDAC的抑制提供益处，如癌症，神经变性疾病，周围神经病，神经病，外伤性脑损伤，中风，高血压，疟疾，自身免疫疾病，自闭症，自闭症谱系障碍， 和炎症，也被公开。