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204 条记录 (耗时 0.032 秒)

    MODULATION OF LIPID METABOLISM FOR PROTEIN PRODUCTION
    2.
    发明申请
    MODULATION OF LIPID METABOLISM FOR PROTEIN PRODUCTION 有权

    公开(公告)号：US20230047838A1

    公开(公告)日：2023-02-16

    申请号：US17815465

    申请日：2022-07-27

    申请人： LONZA LTD

    发明人： James BUDGE ,  Christopher Mark SMALES ,  Tanya Jeane KNIGHT ,  Robert YOUNG

    IPC分类号： C12N9/02 ,  C12P21/02 ,  C07K14/47 ,  C07K16/00 ,  C12N5/071

    摘要： The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved production and quality of recombinant products, such as next generation biologics. Modulation of lipid metabolism as described herein includes, for example, introducing a lipid metabolism modulator described herein to a cell or a cell-free system. Also encompassed by the present disclosure are engineered cells with improved production capacity and improved product quality, methods for engineering such cells, and preparations and mixtures comprising the products from such cells.

    Cell culture system and method
    3.
    发明授权
    Cell culture system and method 有权

    公开(公告)号：US11559811B2

    公开(公告)日：2023-01-24

    申请号：US15891432

    申请日：2018-02-08

    申请人： Lonza Ltd.

    发明人： Jason Bishop ,  Steven Roberts

    IPC分类号： B01L3/00 ,  C12M1/00 ,  C12M1/34

    摘要： A bioprocess system and a method for incubating, growing and harvesting cell cultures is described. Also disclosed is a bioprocess container that can be used with the system. In one aspect of the present disclosure, the bioprocess system includes bioprocess tubes and cell culture tubes having particular dimensions and being made from specific materials that allow the tubes to be welded together while preventing open connections and/or ruptures. In this manner, bioprocess containers can be connected and disconnected from a cell culture apparatus without having to perform the manipulation within a closed environment and without associated monitoring.

    CUSTOMIZABLE FACILITY
    6.
    发明申请
    CUSTOMIZABLE FACILITY 有权

    公开(公告)号：US20220106800A1

    公开(公告)日：2022-04-07

    申请号：US17553283

    申请日：2021-12-16

    申请人： LONZA LTD

    发明人： Jonathan FORTIN ,  Lesley WOOD ,  Stefan WIDMER ,  Sandra CARBONNEAU ,  Alexander ZAHIRI

    IPC分类号： E04H1/00 ,  F24F3/167 ,  C12M1/12 ,  E04H5/02 ,  E04H5/00

    摘要： A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. Each modular unit can be a fermentation unit, a pre-viral unit, a post-viral unit, a utility space, a warehouse, a media buffer facility, an office, a personnel unit, or another unit. The modular units can be arranged to maximize a number of modular units within the shell while minimizing a footprint of the shell. A method of assembling a facility for manufacturing at least one product includes providing at least one central unit and providing at least one modular unit in communication with the central unit(s) such that utilities are provided by the central unit(s) to the modular unit(s).

    METHODS OF ASSAYING TROPOLONE
    9.
    发明申请
    METHODS OF ASSAYING TROPOLONE 有权

    公开(公告)号：US20210178289A1

    公开(公告)日：2021-06-17

    申请号：US16769842

    申请日：2018-12-04

    申请人： LONZA LTD

    发明人： Benjamin Alexander WILKES

    IPC分类号： B01D15/08 ,  C07K16/00 ,  C07C49/717

    摘要： Disclosed herein are methods useful for detecting and/or quantifying tropolone in samples, e.g., generated during the production of and in final formulations of a product, e.g., a recombinant protein, e.g., an antibody. Tropolone and derivatives thereof (cycloheptatriene ketones) are separated from a mixture by adding a partially or fully fluorinated alkyl or aryl (e.g. pentafluorophenyl-propyl), which (covalently) binds the tropolone-like compound. Then it is assayed via UV or tandem mass spectrometry. A reaction mixture of tropolone-like compounds and fluorinated alkyl or aryl is also disclosed.