公开(公告)号：US10968187B2

公开(公告)日：2021-04-06

申请号：US16632572

申请日：2018-07-26

Applicant: Lonza Ltd

Inventor： Christoph Taeschler ,  Florencio Zaragoza Doerwald ,  Stefan Ellinger ,  Matthias Beller ,  Helfried Neumann ,  Florian Fischer

IPC: C07D265/30 ,  B01J31/04 ,  C07C17/275 ,  C07C17/32 ,  C07C21/18 ,  C07D213/26 ,  C07D241/10 ,  C07D333/12 ,  C07D473/10 ,  C07C19/14 ,  C07C22/08 ,  C07C23/36

Abstract: The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively.

公开(公告)号：US10125087B2

公开(公告)日：2018-11-13

申请号：US15747510

申请日：2016-09-14

Applicant: LONZA LTD

Inventor： Christoph Taeschler ,  Ulrich Mayerhoeffer ,  Christophe Girard ,  Michael Bittel ,  Rolf Kalbermatten ,  Claudio Arnold ,  Stefan Garms ,  Christian Schnider ,  Stefan Tille ,  Manuel Favre ,  Guy Raboud ,  Kilian Schnydrig ,  Martin Venetz ,  Thomas Eggel

IPC: C07C201/04 ,  C07C203/00 ,  B01J19/18

Abstract: The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are mixed in a mixing device which provides for a pressure drop of at least 1 bar; the acid is selected from the group consisting of HCI, H2SO4, formic acid, methanesulfonic acid, and mixtures thereof; and the amount of HCI is at least 1.02 molar equivalent based on the molar amount of n-butanol.

公开(公告)号：US09809596B1

公开(公告)日：2017-11-07

申请号：US15522336

申请日：2015-11-05

Applicant: Lonza Ltd

Inventor： Christoph Taeschler ,  Florencio Zaragoza Doerwald ,  Stefan Ellinger ,  Matthias Beller ,  Helfried Neumann ,  Lin He ,  Kishore Natte

IPC: C07D473/10 ,  C07C41/30 ,  C07C17/272 ,  C07C45/68 ,  C07D209/10 ,  C07D207/33 ,  C07D333/12 ,  C07D207/333

CPC classification number: C07D473/10 ,  C07B39/00 ,  C07C17/272 ,  C07C17/275 ,  C07C22/08 ,  C07C41/30 ,  C07C43/225 ,  C07C45/68 ,  C07C45/69 ,  C07C49/80 ,  C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D209/10 ,  C07D333/12 ,  C07D473/08 ,  C07C49/84

Abstract: The invention discloses a method for preparations of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-adamantyl-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperdine 1-oxyl.

公开(公告)号：US20200157063A1

公开(公告)日：2020-05-21

申请号：US16632572

申请日：2018-07-26

Applicant: Lonza Ltd

Inventor： Christoph Taeschler ,  Florencio Zaragoza Doerwald ,  Stefan Ellinger ,  Matthias Beller ,  Helfried Neumann ,  Florian Fischer

IPC: C07D265/30 ,  C07C17/32 ,  C07C17/275 ,  C07C21/18 ,  C07D213/26 ,  C07D333/12 ,  C07D241/10 ,  B01J31/04 ,  C07D473/10

Abstract: The invention discloses a method for preparation of alkylated, fluoro alkylated, chloro alkylated and fluorochloro alkylated compounds by a heterogeneous Co-catalysed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides, fluoro alkyl halides, chloro alkyl halides or fluorochloro alkyl halides respectively.

公开(公告)号：US20180230103A1

公开(公告)日：2018-08-16

申请号：US15751624

申请日：2016-11-14

Applicant: LONZA LTD

Inventor： Christoph Taeschler ,  Christophe Girard ,  Sandro Tonazzi ,  Daniel Polenske ,  Stefan Garms ,  Christoph Escher ,  Andreas Lorenz ,  Sonja Biner ,  Mareile Von Der Gruen ,  Herbert Kuehberger ,  Jonas Zurbriggen ,  Dieter In-Albon ,  Beat Lutz

IPC: C07D231/20

CPC classification number: C07D231/20

Abstract: The invention discloses a method for the preparation of 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol with high selectivity with respect to the content of the isomer 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol.

公开(公告)号：US09771367B2

公开(公告)日：2017-09-26

申请号：US15310295

申请日：2015-06-04

Applicant: Lonza Ltd

Inventor： Christoph Taeschler ,  Matthias Beller ,  Helfried Neumann ,  Lin He ,  Kishore Natte ,  Stefan Ellinger ,  Florencio Zaragoza Doerwald

IPC: C07B37/04 ,  C07D473/12 ,  C07D207/323 ,  C07D333/12 ,  C07D333/28 ,  C07D213/127 ,  C07D213/26 ,  C07C17/32 ,  C07C22/08

CPC classification number: C07D473/12 ,  C07B37/04 ,  C07C17/32 ,  C07C22/08 ,  C07C41/30 ,  C07C45/68 ,  C07C253/30 ,  C07D207/323 ,  C07D213/127 ,  C07D213/26 ,  C07D333/12 ,  C07D333/28 ,  C08F8/24 ,  C07C25/02 ,  C07C255/54 ,  C07C43/225 ,  C07C43/23 ,  C07C49/84 ,  C08F12/08

Abstract: The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs2C03 or CsHC03.

公开(公告)号：US09663436B1

公开(公告)日：2017-05-30

申请号：US15309957

申请日：2015-06-24

Applicant: Lonza Ltd

Inventor： Florencio Zaragoza Doerwald ,  Christoph Taeschler

IPC: C07C45/70

CPC classification number: C07C45/70 ,  C07C49/255

Abstract: The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.

公开(公告)号：US20170137359A1

公开(公告)日：2017-05-18

申请号：US15309957

申请日：2015-06-24

Applicant: Lonza Ltd

Inventor： Florencio Zaragoza Doerwald ,  Christoph Taeschler

IPC: C07C45/70

CPC classification number: C07C45/70 ,  C07C49/255

Abstract: The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.

公开(公告)号：US20160368876A1

公开(公告)日：2016-12-22

申请号：US14898791

申请日：2014-07-17

Applicant: LONZA LTD

Inventor： Florencio Zaragoza Doerwald ,  Michael Bersier ,  Christoph Taeschler

IPC: C07D213/803

CPC classification number: C07D213/803

Abstract: The invention discloses a method for the preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives (I) from trifluoroacetylacetic acid (II) and orthoesters (III), and their use for the preparation of pharmaceutical, chemical or agro-chemical products.

Abstract translation: 本发明公开了一种从三氟乙酰乙酸（Ⅱ）和原酸酯（Ⅲ）制备6-三氟甲基吡啶-3-羧酸衍生物（Ⅰ）的方法及其制备药物，化学或农用化学品的用途。

公开(公告)号：US09458180B2

公开(公告)日：2016-10-04

申请号：US15027008

申请日：2014-09-23

Applicant: Lonza Ltd.

Inventor： Katharina Sievert ,  Axel Schulz ,  Jorg Harloff ,  Stefan Ellinger ,  Christoph Taeschler ,  Cornelia Zur Taeschler

IPC: C07F5/02 ,  C07C209/68 ,  C07D233/58 ,  B01J27/125 ,  B01J29/70 ,  B01J31/02

CPC classification number: C07F5/027 ,  B01J27/125 ,  B01J29/7049 ,  B01J31/0287 ,  C07C209/68 ,  C07D233/58 ,  H01M6/14 ,  H01M10/056 ,  H01M14/005 ,  H01M2300/0022

Abstract: The invention discloses a method for preparation of cyano compounds of the 13th group of the periodic table with 1, 2, 3 or 4 cyano residues, represented by formula (I): [Catn+][Z1F4-m(CN)m)−]n by a reaction of [(Z1F4)−] with trimethylsilylcyanide in the presence of a Lewis acid and in the presence of the cation Catn+; Cat2+ is a cation, Z1 is B, Al, Ga, In or Tl, m is 1, 2, 3 or 4 and n is 1, 2, 3 or 4.

Abstract translation: 本发明公开了一种由式（I）表示的具有1,2,3或4个氰基的周期表第13族的氰基化合物的制备方法：[Catn +] [Z1F4-m（CN）m） - ] 通过[（Z1F4） - ]与三甲基甲硅烷基氰化物在路易斯酸的存在下和在阳离子Catn +存在下的反应; Cat2 +是阳离子，Z1是B，Al，Ga，In或T1，m是1,2,3或4，n是1,2,3或4。