公开(公告)号：US20220168252A1

公开(公告)日：2022-06-02

申请号：US17543479

申请日：2021-12-06

申请人： BIOGEM S.C. A R.L.

发明人： Claudio PISANO ,  Sabrina DALLAVALLE ,  Raffaella CINCINELLI ,  Lucio MERLINI

IPC分类号： A61K31/195 ,  A61P35/00 ,  C07C233/91 ,  A61K9/00

摘要： The present invention relates to compounds of formula (I) and to pharmaceutical compositions containing them: wherein meanings of the substituents are indicated in the description.
Such compounds for use in the treatment of cancer and other diseases related to altered angiogenesis, such as arthritic pathology, diabetic retinopathy, psoriasis and chronic inflammatory disease, are also within the scope of the present invention.

公开(公告)号：US10947474B2

公开(公告)日：2021-03-16

申请号：US16767691

申请日：2018-11-29

申请人： Valvoline Licensing and Intellectual Property LLC

发明人： Shibaji Kumar Ghosh ,  Jesse Dambacher

IPC分类号： C10M133/16 ,  C07C233/91 ,  C10N30/00 ,  C10N40/25 ,  C10N30/02 ,  C10N30/04 ,  C10N30/06 ,  C10N30/10 ,  C10N30/12 ,  C10N30/18

摘要： Novel friction reducing additives provide friction modification at a lower effective concentration when added to a motor oil base. A friction reducing motor oil composition may include motor oil base and a friction reducing additive having the structure of the general formula (I): wherein: R1 is a straight or branched C5-C30 alkyl or alkenyl; R2 is H, or a straight or branched alkyl of C1-C10; R3 is H, or a straight or branched alkyl of C1-C10; P is 0 or C1; n is C1-C5; and m is C0-C5.

公开(公告)号：US10435351B2

公开(公告)日：2019-10-08

申请号：US15882498

申请日：2018-01-29

申请人： SUNOVION PHARMACEUTICALS INC.

发明人： Charles P. Vandenbossche ,  John R. Snoonian

IPC分类号： C07C231/10 ,  C07C249/08 ,  C07C209/62 ,  C07C233/91 ,  C07C231/12 ,  C07C209/50

摘要： A convenient method for converting oximes into enamides is disclosed. The process produces enamides without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines.

公开(公告)号：US09255062B2

公开(公告)日：2016-02-09

申请号：US12988556

申请日：2009-04-21

申请人： Roberto Berni Canani ,  Antonio Calignano ,  Orazio Mazzoni ,  Orietta Mazzoni ,  Anna Coruzzo

发明人： Roberto Berni Canani ,  Antonio Calignano ,  Orazio Mazzoni ,  Anna Coruzzo

IPC分类号： A61K31/40 ,  A61K31/44 ,  A61K31/165 ,  C07D213/127 ,  C07D207/04 ,  C07C15/04 ,  C07C231/02 ,  C07C233/31 ,  C07C233/91

CPC分类号： C07C231/02 ,  C07C233/31 ,  C07C233/91

摘要： The invention relates to novel derivatives of short-chain fatty acids, in particular derivatives of butyric acid, useful for all the known clinical applications of the latter, which show physicochemical characteristics suitable for an easy oral administration, being devoid of the unpleasant organoleptic properties that characterize butyrate. The new compounds are amide derivatives which can be synthesized by reaction of the corresponding fatty acid halide with a naturally occurring amino acid, phenylalanine or a suitable derivative thereof, and which are in a poorly hygroscopic, easily weighable form, stable to acids and alkalis and able to release the acid at the small and large bowel level in a constant manner over time. They do not have disagreeable odors and are practically tasteless, thus allowing the manufacture of preparations for oral administration also suitable for the therapy of chronic diseases and in the pediatric field.

摘要翻译： 本发明涉及短链脂肪酸的新衍生物，特别是丁酸的衍生物，其可用于后者的所有已知临床应用，其显示适合于容易口服给药的物理化学特性，没有令人不愉快的感官特性， 表征丁酸盐。 新化合物是酰胺衍生物，其可以通过相应的脂肪酰卤与天然存在的氨基酸，苯丙氨酸或其合适的衍生物的反应合成，并且它们的吸水性差，易于称重的形式，对酸和碱稳定，并且 能够随着时间的推移以恒定的方式释放小肠和大肠的酸。 它们没有不愉快的气味，几乎没有味道，因此允许口服制剂的制备也适用于治疗慢性疾病和儿科领域。

公开(公告)号：US09139514B2

公开(公告)日：2015-09-22

申请号：US13933551

申请日：2013-07-02

申请人： Sumitomo Chemical Company, Ltd.

发明人： Yujiro Hayashi ,  Hayato Ishikawa

IPC分类号： C07C231/08 ,  C07C231/10 ,  C07C231/12 ,  C07C233/52 ,  C07C231/14 ,  C07C47/198 ,  C07C205/55 ,  C07C233/91 ,  C07C247/22 ,  C07C323/53 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C209/48 ,  C07C201/12 ,  C07C227/04 ,  C07C319/18 ,  C07C319/20 ,  C07C239/18 ,  C07C239/20

CPC分类号： C07C231/14 ,  C07C47/198 ,  C07C201/12 ,  C07C205/55 ,  C07C209/48 ,  C07C227/04 ,  C07C231/08 ,  C07C231/10 ,  C07C231/12 ,  C07C233/52 ,  C07C233/91 ,  C07C239/18 ,  C07C239/20 ,  C07C247/22 ,  C07C319/18 ,  C07C319/20 ,  C07C323/53 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C2601/14 ,  C07C2601/16 ,  C07D209/48 ,  Y02P20/55 ,  C07C205/51 ,  C07C229/48 ,  C07C323/61

摘要： Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound.

摘要翻译： 公开了适用于高产量的大规模合成以生产奥司他韦磷酸盐的方法，其中可以制备作为药物产品高度安全的磷酸奥司他韦的制剂和用于生产磷酸奥司他韦的中间体化合物。 在该制造方法中，通过使用迈克尔反应/迈克尔反应/霍纳沃兹沃斯 - 埃蒙斯反应合成由通式（V）表示的中间体化合物，通过转化该中间体化合物中的取代基来制备磷酸奥司他韦。

公开(公告)号：US09133102B2

公开(公告)日：2015-09-15

申请号：US14175449

申请日：2014-02-07

申请人： Tokyo Ohka Kogyo Co., Ltd.

发明人： Daichi Takaki ,  Daiju Shiono ,  Yoshiyuki Utsumi ,  Takaaki Kaiho

IPC分类号： C07C233/92 ,  C07C233/91 ,  C07C235/88 ,  C07C233/90 ,  C07D493/08 ,  G03F7/30 ,  G03F7/039 ,  G03F7/20 ,  C08F220/18 ,  C08F220/30 ,  C08F220/40

CPC分类号： C07C233/92 ,  C07C233/90 ,  C07C233/91 ,  C07C235/88 ,  C07D493/08 ,  C08F220/18 ,  C08F220/30 ,  C08F220/40 ,  G03F7/0392 ,  G03F7/0397 ,  G03F7/2041 ,  G03F7/30

摘要： A resist composition including a base component (A) which exhibits changed solubility in a developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the base component (A) containing a polymeric compound (A1) having a structural unit (a5) represented by general formula (a5-0) shown below (R1 represents a sulfur atom or an oxygen atom; R2 represents a single bond or a divalent linking group; and Y represents an aromatic hydrocarbon group or an aliphatic hydrocarbon group having a polycyclic group, provided that the aromatic hydrocarbon group or the aliphatic hydrocarbon may have a carbon atom or a hydrogen atom thereof substituted with a substituent.

摘要翻译： 一种抗蚀剂组合物，其包含在酸作用下在显影液中显示出改变的溶解度的碱成分（A）和暴露时产生酸的酸产生剂组分（B），含有高分子化合物（A1）的碱成分（A） 具有下述通式（a5-0）表示的结构单元（a5）（R1表示硫原子或氧原子; R2表示单键或二价连接基团; Y表示芳香族烃基或脂肪族 具有多环基团的烃基，条件是芳族烃基或脂族烃可以具有被取代基取代的碳原子或氢原子。

公开(公告)号：US20050272631A1

公开(公告)日：2005-12-08

申请号：US11116775

申请日：2005-04-28

申请人： Gregory Miracle ,  Robert Dykstra ,  George Hiler

发明人： Gregory Miracle ,  Robert Dykstra ,  George Hiler

IPC分类号： C07C233/91 ,  C07C309/15 ,  C07C309/51 ,  C11D1/00 ,  C11D3/39 ,  C11D3/395 ,  C11D7/32 ,  C11D7/34

CPC分类号： C11D7/34 ,  C07C233/91 ,  C07C309/15 ,  C07C309/51 ,  C11D3/3947 ,  C11D7/3209

摘要： The present invention relates to organic activators having the following general formula: Wherein R1 is a substituted or unsubstituted alkyl or aryl moiety comprising at least five carbons, R2 is a substituted or unsubstituted alkyl moiety comprising less than five carbons, R3 is a suitable bridging moiety, R4 is a charged moiety, N is nitrogen, each G is, independently, an oxygen containing moiety and Z, when present, is a charge balancing counter ion. The present invention also relates to cleaning compositions comprising said organic activators, and processes for making and using the aforementioned organic activators and cleaning compositions.

摘要翻译： 本发明涉及具有以下通式的有机活化剂：其中R 1是取代或未取代的包含至少五个碳的烷基或芳基部分，R 2是取代的 或包含少于五个碳的未取代的烷基部分，R 3是合适的桥连部分，R 4是带电部分，N是氮，每个G独立地是 含氧部分和Z（当存在时）是电荷平衡反离子。 本发明还涉及包含所述有机活化剂的清洁组合物，以及制备和使用上述有机活化剂和清洁组合物的方法。

公开(公告)号：US5641783A

公开(公告)日：1997-06-24

申请号：US303842

申请日：1994-09-08

申请人： J. Peter Klein ,  Gail E. Underiner ,  Anil M. Kumar

发明人： J. Peter Klein ,  Gail E. Underiner ,  Anil M. Kumar

IPC分类号： A61K31/45 ,  A61K31/47 ,  A61K31/513 ,  A61K31/519 ,  A61K31/522 ,  C07C215/08 ,  C07C215/56 ,  C07C217/62 ,  C07C217/64 ,  C07C229/22 ,  C07C233/36 ,  C07C233/78 ,  C07C233/91 ,  C07D207/40 ,  C07D207/404 ,  C07D209/48 ,  C07D211/76 ,  C07D211/88 ,  C07D217/24 ,  C07D239/54 ,  C07D239/90 ,  C07D239/96 ,  C07D295/13 ,  C07D473/10 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/52

CPC分类号： C07D207/404 ,  A61K31/45 ,  A61K31/47 ,  A61K31/513 ,  A61K31/519 ,  A61K31/522 ,  C07C215/08 ,  C07C215/56 ,  C07C217/62 ,  C07C217/64 ,  C07C229/22 ,  C07C233/36 ,  C07C233/78 ,  C07C233/91 ,  C07D209/48 ,  C07D211/76 ,  C07D211/88 ,  C07D217/24 ,  C07D239/54 ,  C07D239/90 ,  C07D239/96 ,  C07D295/13 ,  C07D473/10

摘要： Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocycle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.4 is a terminal moiety comprising a substituted or unsubstituted, oxidized or reduced ring system, the ring system having a single ring or two to three fused rings, a ring comprising from three to seven ring atoms. The disclosed compounds are effective agents to inhibit undesirable responses to cell stimuli.

摘要翻译： 公开了具有式I的直链或支链脂族烃结构的化合物：一至四，m为四至二十的整数。 独立地，R 1和R 2是氢，直链或支链烷基，链烯基或长链多至20个碳原子的炔基或 - （CH 2）w R 5。 如果R 1或R 2是 - （CH 2）w R 5，则w可以是1-20的整数，R 5可以是羟基，卤素，C 1-8烷氧基或取代或未取代的碳环或杂环。 或者，R 1和R 2可以共同形成具有4-8个碳原子的取代或未取代的饱和或不饱和杂环，N是所得杂环的杂原子。 R3可以是氢或C1-3。 在化合物中，包含R 1或R 2，（CH 2）n和（CH 2）m的碳原子总和不超过40个。 R4是包含取代或未取代的氧化或还原环系的末端部分，该环系具有单环或二至三个稠环，包含3-7个环原子的环。 所公开的化合物是抑制对细胞刺激的不良反应的有效试剂。

公开(公告)号：US5502251A

公开(公告)日：1996-03-26

申请号：US383702

申请日：1995-02-01

申请人： Klaus Pohmer ,  Rainer Weber ,  Cornelia Do/ rzbach-Lange ,  Karlheinz Stachulla ,  Hans-Heinrich Moretto ,  Manfred Wienand

发明人： Klaus Pohmer ,  Rainer Weber ,  Cornelia Do/ rzbach-Lange ,  Karlheinz Stachulla ,  Hans-Heinrich Moretto ,  Manfred Wienand

IPC分类号： A61K8/00 ,  A61Q5/00 ,  B01F17/22 ,  B01F17/26 ,  C07B61/00 ,  C07C233/11 ,  C07C233/90 ,  C07C233/91 ,  C07C271/62 ,  C07C275/02 ,  C07C311/48 ,  C07C311/51 ,  C09B67/46 ,  C09D7/47 ,  C09G1/10 ,  C09K3/14 ,  C09K15/22 ,  C09K21/10 ,  C10M133/16 ,  C10M135/10 ,  C10N40/36 ,  C11D1/00 ,  C11D1/02 ,  C23C18/34 ,  C23C18/40 ,  C23F1/14 ,  C25D3/04 ,  C25D3/12 ,  C25D3/38 ,  C25D11/02 ,  C25F1/00 ,  D06M13/02 ,  D06M13/322 ,  D06M13/402 ,  D06M13/408 ,  D06M13/425 ,  D06M13/428 ,  D06M13/438 ,  D21H17/07 ,  D21H21/16 ,  G03C1/38 ,  G03C5/305 ,  C07C311/15 ,  C07C311/09 ,  C07C311/03 ,  C07C233/31

CPC分类号： D06M13/438 ,  C07C233/91 ,  C07C311/48 ,  C07C311/51 ,  C09D7/06 ,  C11D1/004 ,  D06M13/408 ,  D21H21/16 ,  G03C1/385 ,  G03C5/3053

摘要： Fluoroalkyl- and fluoroaryl-group-containing imides and their salts of general formula (I) ##STR1## wherein R.sub.F is a fluoroalkyl group with 1 to 18 carbon atoms, a fluoroaryl group with 6 to 12 carbon atoms or a mixed fluoroalkylaryl group with 7 to 18 carbon atoms, wherein the carbon chain can also be interrupted by oxygen atoms,R.sub.H is an alkyl group with 1 to 30 carbon atoms, an aryl group with 6 to 12 carbon atoms or a mixed alkylaryl group with 7 to 30 carbon atoms, wherein the carbon chain of the group can also be interrupted by oxygen, nitrogen or sulphur atoms,Y.sub.1 and Y.sub.2 independently of each other represent a ##STR2## X is a hydrogen cation or a uni- or multivalent cation, m is a whole number from 0 to 6, andz is a whole number from 1 to 7 corresponding to the charge of the cation X.

摘要翻译： 含氟烷基和含氟芳基的酰亚胺及其通式（I）的盐其中RF是具有1至18个碳原子的氟代烷基，具有6至12个碳原子的氟代芳基或混合的氟代烷基芳基 具有7至18个碳原子的基团，其中碳链也可以被氧原子间隔，RH是具有1至30个碳原子的烷基，具有6至12个碳原子的芳基或具有7至30个的混合烷基芳基 碳原子，其中该基团的碳链也可以被氧，氮或硫原子间隔，Y1和Y2彼此独立地表示X是氢阳离子或单价或多价阳离子，m是 整数为0〜6，z为1〜7的整数，与阳离子X的电荷相对应。

公开(公告)号：US5025033A

公开(公告)日：1991-06-18

申请号：US301065

申请日：1989-01-25

申请人： Giichi Goto ,  Akinobu Nagaoka

发明人： Giichi Goto ,  Akinobu Nagaoka

IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/47 ,  A61P25/02 ,  A61P25/28 ,  A61P43/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/40 ,  C07C233/78 ,  C07C233/91 ,  C07C233/92 ,  C07C235/34 ,  C07C237/00 ,  C07C237/20 ,  C07C237/22 ,  C07C237/28 ,  C07C237/34 ,  C07C237/42 ,  C07C255/57 ,  C07C255/58 ,  C07C311/08 ,  C07C311/13 ,  C07C311/21 ,  C07C317/44 ,  C07C323/60 ,  C07C323/62 ,  C07D209/48 ,  C07D217/12 ,  C07D401/06

CPC分类号： C07D209/48 ,  C07C233/40 ,  C07C235/34 ,  C07C237/20 ,  C07C237/22 ,  C07C255/57 ,  C07C317/44 ,  C07D401/06

摘要： A cholinesterase inhibiting agent which contains an alkylene diamine of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently is a hydrogen atom or a hydrocarbon residue which may optionally be substituted, or R.sup.1 and R.sup.2 combinedly form, together with the adjacent nitrogen atom, a condensed heterocyclic group, R.sup.3 is a hydrogen atom or a hydrocarbon residue or an acyl group which may optionally be substituted and R.sup.4 is a hydrogen atom, or R.sup.3 and R.sup.4 combinedly form a group of the formula ##STR2## or --(CH.sub.2).sub.m+1 -- (m being 0, 1 or 2), A is --(CH.sub.2).sub.l -- (l being 0, 1 or 2) or --CH.dbd.CH--, X is a substituent or substituents and n is an integer of 4 to 7, or a salt thereof, which are useful as cerebral function improving agents for the prevention or treatment of senile dementia, Alzheimer's disease, Huntington's chorea, hyperkinesia, mania and so forth.