公开(公告)号：US20240318064A1

公开(公告)日：2024-09-26

申请号：US18734177

申请日：2024-06-05

申请人： CLARIANT INTERNATIONAL LTD

发明人： Dirk LEINWEBER ,  Zachary Thomas WARD ,  Felix HÖVELMANN ,  Jonathan James WYLDE

IPC分类号： C09K8/52 ,  C07D207/404 ,  C10L1/222 ,  C10L3/10

CPC分类号： C09K8/52 ,  C07D207/404 ,  C10L1/2222 ,  C10L3/107 ,  C09K2208/22

摘要： Provided herein is a composition for inhibiting gas hydrate formation in a system containing hydrocarbons and water. The composition includes (A) an amidoamine of a fatty acid, optionally in the form of a cationic ammonium compound, and (B) a nonionic surfactant selected from alkoxylated C8-C18 fatty alcohols, alkoxylated C8-C18 fatty amines, alkoxylated C8-C18 fatty acids and alkoxylated C8-C18 fatty acid amides, wherein (A) and (B) are present in a weight ratio (A):(B) of from 15:85 to 85:15.

公开(公告)号：US12037537B2

公开(公告)日：2024-07-16

申请号：US17099494

申请日：2020-11-16

申请人： Clariant International, Ltd.

发明人： Dirk Leinweber ,  Zachary Thomas Ward ,  Felix Hoevelmann ,  Jonathan James Wylde

IPC分类号： E21B43/16 ,  C07D207/404 ,  C09K8/52 ,  C10L1/222 ,  C10L3/10

CPC分类号： C09K8/52 ,  C07D207/404 ,  C10L1/2222 ,  C10L3/107 ,  C09K2208/22

摘要： Provided herein is a method for inhibiting gas hydrate formation in a system containing hydrocarbons and water. The method includes contacting the system with a gas hydrate inhibitor composition including an amidoamine of a fatty acid, optionally in the form of a cationic ammonium compound, and a nonionic surfactant selected from alkoxylated C8-C18 fatty alcohols, alkoxylated C8-C18 fatty amines, alkoxylated C8-C18 fatty acids and alkoxylated C8-C18 fatty acid amides.

公开(公告)号：US20230220290A1

公开(公告)日：2023-07-13

申请号：US18121301

申请日：2023-03-14

申请人： ECOLAB USA INC.

发明人： Suresh R. Sriram ,  Nestor U. Soriano, JR. ,  Karina Eureste

IPC分类号： C10L1/232 ,  C07D207/404 ,  C10L10/04 ,  C10L10/08

CPC分类号： C10L1/232 ,  C07D207/404 ,  C10L10/04 ,  C10L10/08 ,  C10L2200/0469 ,  C10L2200/0446

摘要： Lubricity additives for hydrocarbon fuels are provided according to formula I:




wherein n is 1 or 0; each Q is independently selected from oxygen and sulfur; each R is independently selected from C8-C60 alkenyl groups which are substituted or unsubstituted; and L is a linking group comprising 0-20 carbons which may be substituted or unsubstituted and may optionally comprise catenary heteroatoms. Fuel mixtures comprising a hydrocarbon fuel; and a lubricity additive according to the present disclosure are also provided. Methods of making lubricity additives comprise reacting an alkenyl succinic anhydrides (ASA's) with certain bisamides or bisthioamides.

公开(公告)号：US20170334834A1

公开(公告)日：2017-11-23

申请号：US15524250

申请日：2015-11-03

申请人： THROMBOLYTICS, LLC

发明人： Bakshy A. Chibber

IPC分类号： C07C229/28 ,  C07K5/103 ,  C07D487/04 ,  C07C281/12 ,  C07D207/404 ,  C07K5/12 ,  C07K5/083 ,  C07C2601/14

CPC分类号： C07C229/28 ,  C07B2200/07 ,  C07C281/12 ,  C07C381/12 ,  C07C2601/14 ,  C07D207/404 ,  C07D487/04 ,  C07K5/0806 ,  C07K5/1008 ,  C07K5/12

摘要： The present invention provides novel antifibrinilytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding.

公开(公告)号：US20170313656A1

公开(公告)日：2017-11-02

申请号：US15630986

申请日：2017-06-23

申请人： Paul D. Davis ,  D. Scott Wilbur

发明人： Paul D. Davis ,  D. Scott Wilbur

IPC分类号： C07D209/60 ,  C07K16/30 ,  C07K14/605 ,  C07D403/14 ,  C07D257/02 ,  C07D209/48 ,  C07D207/404 ,  C07C331/28 ,  C07C317/44 ,  C07C279/24 ,  C07C271/16 ,  C07C235/48 ,  C07C235/08 ,  A61K51/10 ,  C07K16/40 ,  C07C2603/18

CPC分类号： C07D209/60 ,  A61K47/60 ,  A61K51/106 ,  C07C235/08 ,  C07C235/48 ,  C07C271/16 ,  C07C279/24 ,  C07C317/44 ,  C07C331/28 ,  C07C2603/18 ,  C07D207/404 ,  C07D209/48 ,  C07D257/02 ,  C07D403/14 ,  C07K14/605 ,  C07K16/3069 ,  C07K16/40

摘要： Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.

公开(公告)号：US09700881B2

公开(公告)日：2017-07-11

申请号：US15028205

申请日：2014-10-08

申请人： Emory University

发明人： Lanny S. Liebeskind ,  Matthew Lindale ,  Pavan Kumar Reddy Gangireddy

IPC分类号： B01J31/02 ,  C07C269/06 ,  C07C67/08 ,  C07D209/20 ,  C07C231/02 ,  B01J31/12 ,  B01J31/16 ,  B01J31/18 ,  B01J31/28 ,  C07C227/04 ,  C07C49/00 ,  C07D275/04 ,  C07D207/404 ,  C07D513/04 ,  C07C45/46

CPC分类号： B01J31/0271 ,  B01J31/0218 ,  B01J31/0247 ,  B01J31/12 ,  B01J31/16 ,  B01J31/18 ,  B01J31/28 ,  C07C45/46 ,  C07C49/00 ,  C07C67/08 ,  C07C227/04 ,  C07C231/02 ,  C07C269/06 ,  C07D207/404 ,  C07D209/20 ,  C07D275/04 ,  C07D513/04 ,  C07C69/76 ,  C07C233/65 ,  C07C49/784 ,  C07C49/807

摘要： This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon, such as sulfur, such as a sufur amide nitrogen bond, typically in a heterocycle, such as substituted benzoisothiazolones and derivatives thereof, as a catalyst in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations.

公开(公告)号：US20170008863A1

公开(公告)日：2017-01-12

申请号：US15270651

申请日：2016-09-20

申请人： Hyun-Soon Chong

发明人： Hyun-Soon Chong

IPC分类号： C07D295/15 ,  C07C227/18 ,  C07D217/04 ,  C07D221/06 ,  C07D209/16 ,  C07C209/62 ,  C07C227/02 ,  C07D265/32 ,  C07C253/00 ,  C07C247/06 ,  C07C213/00 ,  C07C319/14 ,  C07D233/61 ,  C07D209/48 ,  C07C327/30 ,  C07D207/408 ,  C07D271/12 ,  C07J43/00 ,  C07C331/28

CPC分类号： C07D295/15 ,  C07B43/00 ,  C07B53/00 ,  C07B2200/07 ,  C07C209/08 ,  C07C209/10 ,  C07C209/62 ,  C07C209/74 ,  C07C213/00 ,  C07C227/16 ,  C07C227/18 ,  C07C247/10 ,  C07C253/14 ,  C07C319/04 ,  C07C319/14 ,  C07C327/06 ,  C07C327/30 ,  C07C331/28 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/404 ,  C07D207/408 ,  C07D209/16 ,  C07D209/48 ,  C07D217/04 ,  C07D221/06 ,  C07D221/10 ,  C07D233/61 ,  C07D255/02 ,  C07D265/32 ,  C07D271/12 ,  C07J43/003 ,  C07C229/16 ,  C07C211/27 ,  C07C229/34 ,  C07C255/42 ,  C07C211/29 ,  C07C215/30 ,  C07C211/49 ,  C07C219/22 ,  C07C323/29

摘要： Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

摘要翻译： 通过用于立体选择性和区域选择性合成治疗和诊断化合物的吖啶鎓离子的亲核开环反应的化合物的立体选择性和区域选择性合成。

公开(公告)号：US20170001957A1

公开(公告)日：2017-01-05

申请号：US15178287

申请日：2016-06-09

申请人： NUtech Ventures

发明人： Stephen DiMagno ,  Bao Hu

IPC分类号： C07D207/46 ,  A61K51/04 ,  C07D207/452

CPC分类号： C07D207/46 ,  C07B59/002 ,  C07D207/404 ,  C07D207/416 ,  C07D207/448 ,  C07D207/452

摘要： This disclosure relates to radioiodinated compounds useful as bioconjugation reagents, and intermediates for making radioiodinated bioconjugation reagents.

摘要翻译： 本公开涉及可用作生物共轭试剂的放射性碘化合物和用于制备放射性碘化生物缀合试剂的中间体。

公开(公告)号：US20160324975A1

公开(公告)日：2016-11-10

申请号：US15216870

申请日：2016-07-22

申请人： Yeda Research and Development Co., Ltd.

发明人： Yoram SHECHTER ,  Matityahu FRIDKIN ,  Haim TSUBERY

IPC分类号： A61K47/48 ,  A61K38/27 ,  A61K38/28 ,  A61K38/22 ,  A61K38/21 ,  A61K31/7036

CPC分类号： A61K47/60 ,  A61K31/7036 ,  A61K38/1709 ,  A61K38/212 ,  A61K38/22 ,  A61K38/2242 ,  A61K38/2278 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K47/54 ,  A61K47/545 ,  C07D207/404 ,  C07D207/416 ,  C07D207/452 ,  C07D403/12

摘要： Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold Fmoc or FMS structure that is highly sensitive to bases and is removable under physiological conditions. The drugs are preferably drugs containing an amino group, most preferably peptides and proteins of low or medium molecular weight. Similar molecules are provided wherein a protein carrier or another polymer carrier replaces the PEG moiety.

公开(公告)号：US20160130240A1

公开(公告)日：2016-05-12

申请号：US14899260

申请日：2014-06-16

申请人： BAYER CROPSCIENCE AKTIENGESELLSCHAFT

发明人： Bernd ALIG ,  Silvia CEREZO-GALVEZ ,  Reiner FISCHER ,  Adeline KOEHLER ,  Julia Johanna HAHN ,  Angela BECKER ,  Kerstin ILG ,  Arnd VOERSTE ,  Daniela PORTZ

IPC分类号： C07D277/54 ,  A01N43/36 ,  C07D233/32 ,  A01N43/50 ,  A01N43/78 ,  C07D233/74 ,  C07D207/404 ,  C07D249/12 ,  A01N43/653 ,  C07D233/96 ,  C07D263/20 ,  A01N43/76 ,  C07D263/44 ,  C07D231/34 ,  A01N43/56 ,  C07D207/22

CPC分类号： C07D277/54 ,  A01N43/36 ,  A01N43/50 ,  A01N43/56 ,  A01N43/653 ,  A01N43/76 ,  A01N43/78 ,  C07D207/22 ,  C07D207/404 ,  C07D231/34 ,  C07D233/32 ,  C07D233/34 ,  C07D233/74 ,  C07D233/96 ,  C07D249/12 ,  C07D263/20 ,  C07D263/44

摘要： The present invention relates to aryl sulfoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and intermediates for preparation thereof. The aryl sulfide and aryl sulfoxide derivatives have the general structure (I) in which the respective radicals are as defined in the description.

摘要翻译： 本发明涉及芳基亚砜衍生物，其用作杀螨剂和用于防治动物害虫的杀虫剂及其制备方法和中间体。 芳基硫醚和芳基亚砜衍生物具有通式（I），其中各个基团如说明书中所定义。