Tranilast compositions and cocrystals

    公开(公告)号:US09822066B2

    公开(公告)日:2017-11-21

    申请号:US15336154

    申请日:2016-10-27

    申请人: NUFORMIX LIMITED

    摘要: New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1 tranilast gentisic acid complex, a 1:1 tranilast gentisic acid cocrystal, a 1:1 tranilast salicylic acid complex, a 1:1 tranilast salicylic acid cocrystal, a 1:1 tranilast urea complex, a 1:1 tranilast urea cocrystal, a 1:1 tranilast 4-aminobenzoic acid complex, a 1:1 tranilast 4-aminobenzoic acid cocrystal, a 1:1 tranilast 2,4-dihydroxybenzoic acid complex and a 1:1 tranilast 2,4-dihydroxybenzoic acid cocrystal. Also disclosed are pharmaceutical compositions containing a tranilast complex or cocrystal of the invention and a pharmaceutically acceptable carrier. Methods of treatment using the tranilast complexes and cocrystals as well as the pharmaceutical compositions are disclosed.

    Bioremediation method of hydrocarbon contaminated soils, water, and/or
sludge using urea-surfactant clathrates
    7.
    发明授权
    Bioremediation method of hydrocarbon contaminated soils, water, and/or sludge using urea-surfactant clathrates 失效
    使用尿素 - 表面活性剂包合物的碳氢化合物污染土壤,水和/或污泥的生物修复方法

    公开(公告)号:US5811290A

    公开(公告)日:1998-09-22

    申请号:US946422

    申请日:1997-10-07

    摘要: A method and composition for enhancing the biodegradation of hydrocarbon contaminated soil, water, and/or sludge are disclosed. The composition comprises an adduct of urea with a non-ionic surfactant and a phosphorous source. The disclosed method provides for the application of a degradation effective amount of a composition which comprises a N:P ratio which ranges from 10:2 to about 10:0.5 and the urea and non-ionic surfactant are present in the adduct in a weight ratio ranging from 98:2 to 75:25. Further, the method of biodegradation is carried out by the application of the composition to provide for a C:N:P ratio of 100:10:1 to 100:1:001. The C:N:P ratio is based on the weight percent of the hydrocarbon contaminate in the soil, water and/or sludge sites to be treated. Surfactants which are useful in the disclosed composition and method have from about 2 to fifty ethylene oxide groups; and comprise such compounds as alkylethoxylates, alkyl ethoxylated phosphates, alkyl ethoxylated amines, alkylethoxylated ammonium salts, etc.

    摘要翻译: 公开了一种用于增强烃污染的土壤,水和/或污泥的生物降解的方法和组合物。 组合物包含尿素与非离子表面活性剂和磷源的加合物。 所公开的方法提供降解有效量的组合物的应用,该组合物包含10:2至约10:0.5的N:P比,并且尿素和非离子表面活性剂以重量比存在于加合物中 从98:2到75:25。 此外,生物降解的方法是通过施用组合物来提供100:10:1-100:1:001的C:N:P比。 C:N:P比是基于待处理的土壤,水和/或污泥位置中碳氢化合物污染物的重量百分比。 在所公开的组合物和方法中有用的表面活性剂具有约2-50个环氧乙烷基团; 并且包括诸如烷基乙氧基化物,烷基乙氧基化磷酸酯,烷基乙氧基化胺,烷基乙氧基化铵盐等的化合物