公开(公告)号：US11926574B2

公开(公告)日：2024-03-12

申请号：US17835764

申请日：2022-06-08

申请人： Entheogenix Biosciences, Inc.

发明人： Glenn Short ,  Robert B. Perni ,  Benjamin Robert Difrancesco ,  Tanweer A. Khan

IPC分类号： C07C225/16 ,  C07C381/10

CPC分类号： C07C225/16 ,  C07C381/10

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental health disease or disorder.

公开(公告)号：US20180111890A1

公开(公告)日：2018-04-26

申请号：US15790570

申请日：2017-10-23

申请人： Strides Shasun Limited

发明人： Sankar Arjunan ,  Dhanapal Ramu ,  Sasidaran Manjiny

IPC分类号： C07C51/377 ,  C07C221/00 ,  C07C51/41 ,  C07C51/43 ,  C07C211/03 ,  C07C59/215

CPC分类号： C07C51/377 ,  C07B2200/13 ,  C07C51/02 ,  C07C51/41 ,  C07C51/43 ,  C07C59/215 ,  C07C211/03 ,  C07C221/00 ,  C07C59/90 ,  C07C225/16

摘要： The invention provides an improved process for preparing Ethacrynic acid of formula I, including the steps of: (a) reacting 4-butyryl-2,3-dichloro-phenoxy acetic acid of formula II with dimethylamine or its salt to obtain [2,3-dichloro-4-[2-dimethylaminomethyl butyryl phenoxy acetic acid of formula III or its salt; (b) hydrolysing [2,3-dichloro-4-[2-dimethylaminomethyl butyryl phenoxy acetic acid hydrochloride of formula III obtained in step a) with t-butyl amine to obtain t-butyl amine salt of Ethacrynic acid; (c) acidifying the t-butyl amine salt of Ethacrynic acid formed in step b) to obtain Ethacrynic acid of formula I; and(d) optionally purifying the obtained Ethacrynic acid with a solvent mixture of alkyl acetate and hydrocarbon solvent. The invention also provides crystalline t-butylamine salt of Ethacrynic acid and process thereof. Also provide compound Ethacrynic acid having a purity of greater than or equal to 99% and a composition including the compound.

公开(公告)号：US20170121263A1

公开(公告)日：2017-05-04

申请号：US14929216

申请日：2015-10-30

申请人： Michael Pesek Marshak

发明人： Michael Pesek Marshak

IPC分类号： C07C49/835 ,  C07C225/20 ,  C07D233/58 ,  C07C49/84 ,  C07F7/18

CPC分类号： C07C225/20 ,  C07C49/84 ,  C07C49/92 ,  C07C225/16 ,  C07C2601/14 ,  C07D233/58 ,  C07F7/1804

摘要： This disclosure provides, molecular metal catalysts supported by sterically bulky β-diketonate (acac) ligands. Disclosed herein are bulky β-diketonate ligands, methods of making bulky β-diketonate ligands, and methods of making metal catalysts supported by sterically bulky β-diketonate (acac) ligands.

公开(公告)号：US09562001B2

公开(公告)日：2017-02-07

申请号：US13271419

申请日：2011-10-12

申请人： Frank Ivy Carroll ,  Bruce Edward Blough ,  Philip Abraham

发明人： Frank Ivy Carroll ,  Bruce Edward Blough ,  Philip Abraham

IPC分类号： A61K31/137 ,  C07C225/18 ,  A61P25/24 ,  A61P3/04 ,  A61P25/34 ,  A61P25/00 ,  A61P3/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/06 ,  A61P25/36 ,  A01N33/24 ,  C07C225/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35

CPC分类号： C07C225/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C225/18 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14

摘要： The invention provides bupropion analog compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.

摘要翻译： 本发明提供能够抑制一种或多种单胺再摄取的安非他酮类似物。 化合物可以选择性地结合一种或多种单胺转运蛋白，包括用于多巴胺，去甲肾上腺素和5-羟色胺的单胺转运蛋白。 这样的化合物可用于治疗对单胺再摄取的抑制作用有反应的病症，包括成瘾，抑郁和肥胖。

公开(公告)号：US09481680B2

公开(公告)日：2016-11-01

申请号：US14900858

申请日：2015-01-19

申请人： F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Ottorino De Lucchi ,  Enrico Rosso ,  Simone Zaramella ,  Stefano Tartaggia

IPC分类号： C07C271/18 ,  C07C221/00 ,  C07C225/10 ,  C07C245/24 ,  C07D309/14 ,  C07D487/04 ,  C07C225/16 ,  C07C269/08

CPC分类号： C07D487/04 ,  C07C221/00 ,  C07C225/10 ,  C07C225/16 ,  C07C245/24 ,  C07C269/08 ,  C07D309/14 ,  C07C271/18

摘要： An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a compound having the following formula (I) wherein R1 is propargyl or allyl group and P is an amine protecting group. The compound of formula (I) is prepared by converting a compound of formula (IV) by an amination reaction to a compound of formula (III), which is then protected to provide a compound of formula (II), which is then alkylated to provide the compound of formula (I).

公开(公告)号：US20160060243A1

公开(公告)日：2016-03-03

申请号：US14938896

申请日：2015-11-12

申请人： Coloplast A/S

发明人： Niels Joergen Madsen ,  Petr Sehnal ,  Christian B. Nielsen ,  David George Anderson

IPC分类号： C07D335/16 ,  C08G18/50

CPC分类号： C07D335/16 ,  C07C213/02 ,  C07C217/22 ,  C07C217/62 ,  C07C221/00 ,  C07C225/16 ,  C07C225/22 ,  C07D207/416 ,  C08F2/50 ,  C08G18/3275 ,  C08G18/4833 ,  C08G18/5024 ,  C08G18/5072 ,  C08G18/73 ,  C08G18/758 ,  C08J3/24 ,  C08J3/28 ,  C08J2375/00 ,  C09D175/12

摘要： The present invention provides novel photoinitiators for polyurethane formation, in which a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure, and thus the polyurethane polymer.

公开(公告)号：US09266817B2

公开(公告)日：2016-02-23

申请号：US14336911

申请日：2014-07-21

申请人： EMORY UNIVERSITY

发明人： Keqiang Ye

IPC分类号： A61K31/05 ,  A61K31/12 ,  A61K31/133 ,  A61K31/135 ,  C07C225/16 ,  C07C215/60 ,  C07C237/20 ,  A61K31/137

CPC分类号： C07C225/16 ,  A61K31/05 ,  A61K31/12 ,  A61K31/133 ,  A61K31/135 ,  A61K31/137 ,  C07C215/60 ,  C07C237/20

摘要： Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing a catecholamine backbone and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. Specifically, methods, compositions, and compounds for the treatment of disorders including neurological disorders, neuropsychiatric disorders, and metabolic disorders are provided. For example, a first method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes administering to the subject a therapeutically effective amount of the described compounds. A further method of promoting neuroprotection in a subject also is provided, which includes administering to the subject a therapeutically effective amount of the described compounds.

摘要翻译： 提供了与TrkB受体活化相关的新型化合物，组合物和方法。 所述方法包括在体内或体外施用治疗有效量的含有儿茶酚胺骨架的化合物及其药学上可接受的盐，前药和衍生物。 具体地，提供了用于治疗包括神经障碍，神经精神障碍和代谢紊乱的疾病的方法，组合物和化合物。 例如，提供了治疗或降低受试者的抑郁，焦虑或肥胖的风险的第一种方法，其包括向受试者施用治疗有效量的所述化合物。 还提供了在受试者中促进神经保护作用的另一种方法，其包括向受试者施用治疗有效量的所述化合物。

公开(公告)号：US09212160B2

公开(公告)日：2015-12-15

申请号：US14576237

申请日：2014-12-19

申请人： Coloplast A\S

发明人： Niels Joergen Madsen ,  Petr Sehnal ,  Christian B. Nielsen ,  David George Anderson

IPC分类号： C07D335/16 ,  C07D207/416 ,  C08F2/50 ,  C08G18/32 ,  C08G18/48 ,  C08G18/50 ,  C08G18/73 ,  C08G18/75 ,  C07C217/22 ,  C07C225/16 ,  C07C225/22 ,  C08J3/24 ,  C08J3/28 ,  C09D175/12 ,  C07C213/02 ,  C07C221/00 ,  C07C217/62

CPC分类号： C07D335/16 ,  C07C213/02 ,  C07C217/22 ,  C07C217/62 ,  C07C221/00 ,  C07C225/16 ,  C07C225/22 ,  C07D207/416 ,  C08F2/50 ,  C08G18/3275 ,  C08G18/4833 ,  C08G18/5024 ,  C08G18/5072 ,  C08G18/73 ,  C08G18/758 ,  C08J3/24 ,  C08J3/28 ,  C08J2375/00 ,  C09D175/12

摘要： The present invention provides novel photoinitiators for polyurethane formation, in which a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure, and thus the polyurethane polymer.

摘要翻译： 本发明提供了用于聚氨酯形成的新型光引发剂，其中将光引发剂部分和叔胺引入到光引发剂结构中，从而聚氨酯聚合物。

公开(公告)号：US20150353477A1

公开(公告)日：2015-12-10

申请号：US14733057

申请日：2015-06-08

申请人： Dow AgroSciences LLC

发明人： Paul Renee LePlae, JR. ,  James E. Hunter ,  Gerald B. Watson ,  William C. Lo ,  John Herbert

IPC分类号： C07C233/83 ,  A01N37/34 ,  A01N37/18

CPC分类号： C07C225/16 ,  A01N33/08 ,  A01N37/18 ,  A01N37/20 ,  A01N37/26 ,  A01N37/28 ,  A01N37/34 ,  A01N37/36 ,  A01N37/44 ,  A01N41/10 ,  A01N53/00 ,  C07B2200/07 ,  C07C233/78 ,  C07C233/83 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C317/28 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/02

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).

摘要翻译： 本公开涉及具有杀虫效力的分子领域，用于在叶螨（Phyla Nematoda），节肢动物（Arthropoda）和/或软体动物（Mollusca）中的害虫，产生这种分子的方法和用于该方法的中间体，含有这些分子的组合物，以及使用这种分子对这种害虫 。 这些分子可以用作例如杀线虫剂，杀螨剂，杀虫剂，杀螨剂和/或杀软体动物剂。 该文献公开了具有下式（“一级方程式”）的分子。

公开(公告)号：US20150272910A1

公开(公告)日：2015-10-01

申请号：US14738221

申请日：2015-06-12

申请人： CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL

发明人： Bernd CLEMENT ,  Franz FURKERT ,  Britta GERIG ,  Dieter HEBER

IPC分类号： A61K31/14

CPC分类号： A61K31/14 ,  A61K31/135 ,  A61K33/22 ,  C07C211/29 ,  C07C211/63 ,  C07C225/16

摘要： The invention relates to the use of a substance of the general form (I) to produce an antibacterial and/or antifungal drug, wherein X is a methylene group or a carbonyl group; R1, R2, and R3 are each selected from the group comprising hydrogen, an alkyl group having a chain length of 1-4 carbon atoms, an alkoxy group having a chain length of 1-3 carbon atoms, and a halogen; R4 and R5 are each selected from the group comprising hydrogen and an alkyl group having a chain length of 1-4 carbon atoms; and n=3 to 6.

摘要翻译： 本发明涉及一般形式（I）物质生产抗菌和/或抗真菌药物的用途，其中X为亚甲基或羰基; R1，R2和R3各自选自氢，链长为1-4个碳原子的烷基，链长为1-3个碳原子的烷氧基和卤素; R4和R5各自选自氢和链长为1-4个碳原子的烷基; n = 3〜6。