公开(公告)号：US12116399B2

公开(公告)日：2024-10-15

申请号：US16760206

申请日：2018-11-01

申请人： QUEEN'S UNIVERSITY AT KINGSTON ,  KINGSTON HEALTH SCIENCES CENTRE ,  EMORY UNIVERSITY ,  GEORGIA TECH RESEARCH CORPORATION

发明人： Philip Zakas ,  David Lillicrap ,  Christopher Doering ,  Eric Gaucher ,  Caelan Radford ,  Harold Trent Spencer

IPC分类号： C07K14/745 ,  A61K38/36 ,  A61P7/04 ,  C07K14/755 ,  C12N15/86 ,  A61K38/00

CPC分类号： C07K14/755 ,  A61P7/04 ,  C12N15/86 ,  A61K38/00 ,  C12N2740/10043

摘要： A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.

公开(公告)号：US20240301349A1

公开(公告)日：2024-09-12

申请号：US18440821

申请日：2024-02-13

申请人： University of Georgia Research Foundation, Inc. ,  Emory University

发明人： Charles A. Easley, IV ,  Anthony W.S. Chan

IPC分类号： C12N5/073 ,  C12N5/076 ,  C12N15/90

CPC分类号： C12N5/0604 ,  C12N5/061 ,  C12N15/90 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2517/10

摘要： Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.

公开(公告)号：US20240271092A1

公开(公告)日：2024-08-15

申请号：US18510060

申请日：2023-11-15

申请人： Emory University

发明人： Edmund Waller ,  Anna Morris ,  Christopher Petersen ,  Jian-Ming Li ,  Reema Panjwani ,  Jingxia Li

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61K35/28 ,  A61K38/20 ,  A61K38/22 ,  A61K38/48 ,  A61K38/54 ,  A61K39/39 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

CPC分类号： C12N5/0638 ,  A61K35/17 ,  A61K35/28 ,  A61K38/208 ,  A61K38/22 ,  A61K38/482 ,  A61K38/4886 ,  A61K38/54 ,  A61K39/39 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0636 ,  C12Y304/21039 ,  C12Y304/24011 ,  C12N2501/05 ,  C12N2501/51 ,  C12N2501/515

摘要： This disclosure relates to compositions and methods of reversing senescence in T cells by interrupting vasoactive intestinal peptide (VIP) signalling and/or inhibiting phosphatidylinositol-3-kinase (PI3 kinase) inhibitor signalling and uses in managing cancer and chronic viral infections. In certain embodiments, the disclosure contemplates methods of reversing T cell senescence by mixing T cell in vitro with an agent that prevents VIP from interacting with VIP receptors and/or a PI3 Kinase inhibitor. In certain embodiments, the disclosure contemplates the expansion of senescent T cells by mixing with a PI3 kinase inhibitor, an agent that block VIP and VIP receptor signalling, a VIP degrading enzyme, and combinations thereof.

公开(公告)号：US20240262857A1

公开(公告)日：2024-08-08

申请号：US18562911

申请日：2022-05-27

申请人： Emory University

发明人： Raymond F. Schinazi ,  Frank Amblard

IPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K45/06 ,  A61P31/14 ,  C07B59/00

CPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K45/06 ,  A61P31/14 ,  C07B59/002 ,  C07B2200/05

摘要： Deuterated and/or methylated N4-hydroxycytidine (NHC) analogs, with deuteration at one or both of the 2′- and 3′-positions on the ribo-sugar moiety and/or methylation of the 3′-positions on the ribo-sugar moiety, pharmaceutical compositions comprising one or more of these compounds, and, optionally, at least one additional therapeutic agent, and methods of treating or preventing infections caused by RNA viruses, curing an infection by an RNA virus, or reducing the biological activity of an RNA virus, are disclosed. Representative RNA viruses include, but are not limited to, Coronaviridae, such as MERSr-CoV, SARS-CoV-1, SARSCoV-2, HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1, Picornaviridae, Hepeviridae, Noroviruses, Zika, Dengue, Mayaro, Influenza A and B, Parainfluenza, HCV, Rinovirus, tick-borne viruses, Ebola, Lassa, RSV, adenoviruses, enteroviruses, metapneumoviruses, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), and Chikungunya fever (CHIK).

公开(公告)号：US20240262840A1

公开(公告)日：2024-08-08

申请号：US18629562

申请日：2024-04-08

申请人： EMORY UNIVERSITY

发明人： Keqiang Ye

IPC分类号： C07D491/052 ,  A61K9/00 ,  A61K31/4184 ,  A61P25/24 ,  A61P25/28

CPC分类号： C07D491/052 ,  A61K9/0053 ,  A61K31/4184 ,  A61P25/24 ,  A61P25/28

摘要： In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as depression, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof.

公开(公告)号：US20240238298A1

公开(公告)日：2024-07-18

申请号：US18561673

申请日：2022-05-26

申请人： Emory University

发明人： Christina Gavegnano ,  Susan Pereira Ribeiro

IPC分类号： A61K31/519 ,  A61K39/00 ,  A61K39/39

CPC分类号： A61K31/519 ,  A61K39/39 ,  A61K2039/55511

摘要： This disclosure relates to uses of JAK inhibitors for treating Down's Syndrome and other conditions associated with trisomy or preventing or reversing the deterioration of conditions or symptoms associated therewith. In certain embodiments, this disclosure relates to methods of treating Down's Syndrome or other trisomy comprising administering an effective amount of a JAK Inhibitor to a subject in need thereof.

公开(公告)号：US20240217979A1

公开(公告)日：2024-07-04

申请号：US18287844

申请日：2022-04-21

申请人： Emory University

发明人： Dennis C. Liotta ,  Stephen F. Traynelis ,  David S. Menaldino ,  Peipei Ma

IPC分类号： C07D487/04 ,  A61K31/415 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D231/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC分类号： C07D487/04 ,  A61K31/415 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/5025 ,  A61K31/519 ,  C07D231/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds that selectively inhibit the GluN2 subunits of NMDA receptors are disclosed. In general, the compounds have superior activity against GluN2C/D subunit(s) over GluN2A/B subunit(s). Optionally, the compounds have a structure of Formulas (I), (II), (III), or other formulas disclosed herein, enantiomers or diastereomers thereof, or pharmaceutically acceptable salts thereof. Pharmaceutical formulations containing one or more of the compounds are also disclosed. Additionally, methods of treating a neurological condition or disorder using the compounds or their pharmaceutical formulations thereof are disclosed. Exemplary neurological conditions or disorders include Parkinson's disease, dystonia and related motor disorders, depression, neuropsychiatric indications, stoke, hypoxia, traumatic brain injury, acute injuries involving the white matter, Alzheimer's disease, compulsivity and related disorders, and epilepsy.

公开(公告)号：US12023379B2

公开(公告)日：2024-07-02

申请号：US17132320

申请日：2020-12-23

申请人： Emory University

发明人： Periasamy Selvaraj

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/385 ,  A61K39/0011 ,  A61K39/001102 ,  A61K39/001106 ,  A61K39/001124 ,  A61K39/001129 ,  A61K39/00117 ,  A61K39/001172 ,  A61K39/001173 ,  A61K39/001182 ,  A61K39/00119 ,  A61K39/001191 ,  A61K39/001193 ,  A61K39/001194 ,  A61K39/001195 ,  A61K39/39 ,  A61K2039/515 ,  A61K2039/5152 ,  A61K2039/5258 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/55533 ,  A61K2039/55538 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/62 ,  A61K2039/627

摘要： In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition or tumor vaccine defined herein. The tumor therapeutic composition or tumor vaccine can be produced by protein transfer of glycosyl-phosphatidylinositol (GPI)-anchored immunostimulatory or costimulatory molecules.

公开(公告)号：US20240206841A1

公开(公告)日：2024-06-27

申请号：US18288503

申请日：2022-04-26

申请人： Emory University

发明人： Matthew Timothy Brown ,  Keval Bollavaram ,  Sil Savla ,  Atharv Vikram Marathe ,  Abhiramgopal Akella ,  Ahdil Gill

IPC分类号： A61B7/04 ,  A61B5/00 ,  A61B5/282 ,  A61B5/308 ,  A61B5/33 ,  A61B5/332 ,  A61B5/333

CPC分类号： A61B7/04 ,  A61B5/0006 ,  A61B5/002 ,  A61B5/282 ,  A61B5/308 ,  A61B5/33 ,  A61B5/332 ,  A61B5/333 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0431 ,  A61B2560/0462 ,  A61B2562/04 ,  A61B2562/06

摘要： The disclosure relates to devices, systems and methods for cost effective and user-friendly handheld auscultation. In one implementation, the device may include a housing having a first end, a second end, and a circumference disposed there between. The device may further include a spherical bell disposed at the first end of the housing. The device may further include a microphone disposed below the spherical bell and configured to record auscultation signal data. The device may also include one or more cardiac sensors disposed along the circumference and configured to record cardiac signal data. The device may further include a microprocessor disposed in the housing and configured to process the auscultation and cardiac signal data.

公开(公告)号：US20240189335A1

公开(公告)日：2024-06-13

申请号：US18390347

申请日：2023-12-20

申请人： EMORY UNIVERSITY

发明人： George R. PAINTER ,  Gregory R. BLUEMLING ,  Michael G. NATCHUS ,  David GUTHRIE

IPC分类号： A61K31/7068 ,  A61P31/12 ,  C07H19/067

CPC分类号： A61K31/7068 ,  A61P31/12 ,  C07H19/067

摘要： This disclosure relates to certain N4-hydroxycytidine derivatives, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of viral infections, such as Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), Chikungunya fever (CHIK), Ebola, Influenza, RSV, and Zika virus infection with the disclosed compounds.