公开(公告)号：US20190144825A1

公开(公告)日：2019-05-16

申请号：US16092068

申请日：2017-04-05

申请人： Emory University

发明人： Edmund Waller ,  Anna Morris ,  Christopher Petersen ,  Jian-Ming Li ,  Reema Panjwani ,  Jingxia Li

IPC分类号： C12N5/0783 ,  A61K35/28 ,  A61K35/17 ,  A61K38/22 ,  A61K38/54 ,  A61P35/00 ,  C07K16/28 ,  A61P31/00

摘要： This disclosure relates to compositions and methods of reversing senescence in T cells by interrupting vasoactive intestinal peptide (VIP) signaling and/or inhibiting phosphatidylinositol-3-kinase (PI3 kinase) inhibitor signaling and uses in managing cancer and chronic viral infections. In certain embodiments, the disclosure contemplates methods of reversing T cell senescence by mixing T cell in vitro with an agent that prevents VIP from interacting with VIP receptors and/or a PI3 Kinase inhibitor. In certain embodiments, the disclosure contemplates the expansion of senescent T cells by mixing with a PI3 kinase inhibitor, an agent that block VIP and VIP receptor signaling, a VIP degrading enzyme, and combinations thereof.

公开(公告)号：US20240271092A1

公开(公告)日：2024-08-15

申请号：US18510060

申请日：2023-11-15

申请人： Emory University

发明人： Edmund Waller ,  Anna Morris ,  Christopher Petersen ,  Jian-Ming Li ,  Reema Panjwani ,  Jingxia Li

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61K35/28 ,  A61K38/20 ,  A61K38/22 ,  A61K38/48 ,  A61K38/54 ,  A61K39/39 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28

CPC分类号： C12N5/0638 ,  A61K35/17 ,  A61K35/28 ,  A61K38/208 ,  A61K38/22 ,  A61K38/482 ,  A61K38/4886 ,  A61K38/54 ,  A61K39/39 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0636 ,  C12Y304/21039 ,  C12Y304/24011 ,  C12N2501/05 ,  C12N2501/51 ,  C12N2501/515

摘要： This disclosure relates to compositions and methods of reversing senescence in T cells by interrupting vasoactive intestinal peptide (VIP) signalling and/or inhibiting phosphatidylinositol-3-kinase (PI3 kinase) inhibitor signalling and uses in managing cancer and chronic viral infections. In certain embodiments, the disclosure contemplates methods of reversing T cell senescence by mixing T cell in vitro with an agent that prevents VIP from interacting with VIP receptors and/or a PI3 Kinase inhibitor. In certain embodiments, the disclosure contemplates the expansion of senescent T cells by mixing with a PI3 kinase inhibitor, an agent that block VIP and VIP receptor signalling, a VIP degrading enzyme, and combinations thereof.

公开(公告)号：US11859208B2

公开(公告)日：2024-01-02

申请号：US16092068

申请日：2017-04-05

申请人： Emory University

发明人： Edmund Waller ,  Anna Morris ,  Christopher Petersen ,  Jian-Ming Li ,  Reema Panjwani ,  Jingxia Li

IPC分类号： C12N5/0783 ,  A61K45/06 ,  A61K38/48 ,  A61K35/17 ,  A61P35/00 ,  A61K38/20 ,  A61K39/39 ,  A61P31/00 ,  A61K35/28 ,  A61K38/22 ,  A61K38/54 ,  C07K16/28

CPC分类号： C12N5/0638 ,  A61K35/17 ,  A61K35/28 ,  A61K38/208 ,  A61K38/22 ,  A61K38/482 ,  A61K38/4886 ,  A61K38/54 ,  A61K39/39 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0636 ,  C12Y304/21039 ,  C12Y304/24011 ,  C12N2501/05 ,  C12N2501/515

摘要： This disclosure relates to compositions and methods of reversing senescence in T cells by interrupting vasoactive intestinal peptide (VIP) signaling and/or inhibiting phosphatidylinositol-3-kinase (PI3 kinase) inhibitor signaling and uses in managing cancer and chronic viral infections. In certain embodiments, the disclosure contemplates methods of reversing T cell senescence by mixing T cell in vitro with an agent that prevents VIP from interacting with VIP receptors and/or a PI3 Kinase inhibitor. In certain embodiments, the disclosure contemplates the expansion of senescent T cells by mixing with a PI3 kinase inhibitor, an agent that block VIP and VIP receptor signaling, a VIP degrading enzyme, and combinations thereof.