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公开(公告)号：US20170349537A1
公开(公告)日：2017-12-07
申请号：US15683348
申请日：2017-08-22
申请人： Cortexyme, Inc.
IPC分类号： C07C233/78 , C07D409/12 , C07D277/64 , C07D213/50 , C07C247/16 , C07D417/12 , C07C233/62
CPC分类号： C07D417/12 , C07B2200/07 , C07C233/62 , C07C233/78 , C07C247/16 , C07C247/18 , C07C2601/08 , C07D213/50 , C07D213/53 , C07D277/24 , C07D277/28 , C07D277/64 , C07D409/12
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US10906881B2
公开(公告)日：2021-02-02
申请号：US15975490
申请日：2018-05-09
申请人： Cortexyme, Inc.
IPC分类号： C07C279/12 , A61P31/04 , C07D277/64 , C07D417/12
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US10676470B2
公开(公告)日：2020-06-09
申请号：US16399821
申请日：2019-04-30
申请人： Cortexyme, Inc.
IPC分类号： C07C233/62 , C07C233/78 , C07C247/16 , C07D417/12 , C07D277/64 , C07D409/12 , C07D213/50 , C07C247/18 , C07D277/24 , C07D213/53 , C07D277/28
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US09758473B2
公开(公告)日：2017-09-12
申请号：US14875416
申请日：2015-10-05
申请人： Cortexyme, Inc.
IPC分类号： C07C247/16 , C07C233/62 , C07C233/78 , C07D417/12 , C07D277/64 , C07D409/12 , C07D213/50
CPC分类号： C07D417/12 , C07B2200/07 , C07C233/62 , C07C233/78 , C07C247/16 , C07C247/18 , C07C2601/08 , C07D213/50 , C07D213/53 , C07D277/24 , C07D277/28 , C07D277/64 , C07D409/12
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US20180346460A1
公开(公告)日：2018-12-06
申请号：US15996660
申请日：2018-06-04
申请人： Cortexyme, Inc.
IPC分类号： C07D417/12 , C07D213/50 , C07D409/12 , C07D277/64 , C07D277/24 , C07C247/16 , C07D277/28 , C07D213/53 , C07C233/62 , C07C233/78 , C07C247/18
CPC分类号： C07D417/12 , C07B2200/07 , C07C233/62 , C07C233/78 , C07C247/16 , C07C247/18 , C07C2601/08 , C07D213/50 , C07D213/53 , C07D277/24 , C07D277/28 , C07D277/64 , C07D409/12
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US09988375B2
公开(公告)日：2018-06-05
申请号：US15683348
申请日：2017-08-22
申请人： Cortexyme, Inc.
IPC分类号： C07D417/12 , C07D277/28 , C07D213/53 , C07D277/64 , C07C233/62 , C07C247/16 , C07D409/12 , C07D213/50 , C07C233/78
CPC分类号： C07D417/12 , C07B2200/07 , C07C233/62 , C07C233/78 , C07C247/16 , C07C247/18 , C07C2601/08 , C07D213/50 , C07D213/53 , C07D277/24 , C07D277/28 , C07D277/64 , C07D409/12
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US20190322659A1
公开(公告)日：2019-10-24
申请号：US16399821
申请日：2019-04-30
申请人： Cortexyme, Inc.
IPC分类号： C07D417/12 , C07D213/53 , C07D409/12 , C07D277/24 , C07C247/18 , C07D277/28 , C07D277/64 , C07C233/62 , C07C233/78 , C07C247/16 , C07D213/50
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US10301301B2
公开(公告)日：2019-05-28
申请号：US15996660
申请日：2018-06-04
申请人： Cortexyme, Inc.
IPC分类号： C07D417/12 , C07D213/53 , C07D277/28 , C07D277/64 , C07C233/62 , C07C233/78 , C07C247/16 , C07D409/12 , C07D213/50 , C07C247/18 , C07D277/24
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US11332464B2
公开(公告)日：2022-05-17
申请号：US16866022
申请日：2020-05-04
申请人： Cortexyme, Inc.
IPC分类号： C07D417/12 , C07D277/28 , C07D277/24 , C07C233/78 , C07D277/64 , C07D409/12 , C07D213/50 , C07C247/16 , C07C233/62 , C07C247/18 , C07D213/53
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US20210017167A1
公开(公告)日：2021-01-21
申请号：US16866022
申请日：2020-05-04
申请人： Cortexyme, Inc.
IPC分类号： C07D417/12 , C07D277/64 , C07D409/12 , C07D213/50 , C07C247/16 , C07C233/78 , C07C233/62 , C07C247/18 , C07D277/24 , C07D213/53 , C07D277/28
摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.
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