公开(公告)号：US07434508B2

公开(公告)日：2008-10-14

申请号：US11198624

申请日：2005-08-05

Applicant: Kevin L. Corcoran ,  Carl Von Hirsch ,  David L. Hughes, Jr.

Inventor： Kevin L. Corcoran ,  Carl Von Hirsch ,  David L. Hughes, Jr.

IPC: B30B1/12 ,  B30B1/14

CPC classification number: B26F1/40 ,  B26D5/16 ,  Y10T83/8838

Abstract: Disclosed is a die press with a base, at least two cam members spaced from the base, an upper platen located between the base and the two cam members to define a space for a die, the upper platen being generally parallel to the base, the upper platen also being attached to the two cam members so that when the two cam members are actuated, the upper platen is moveable relative to the base, and a linkage connecting the two cam members so that the two cam members move in unison relative to each other when actuated.

Abstract translation: 公开了一种具有底座的模压机，与基座间隔开的至少两个凸轮构件，位于基座和两个凸轮构件之间的上压板，以限定模具的空间，上压板大致平行于底座， 上压板也附接到两个凸轮构件，使得当两个凸轮构件被致动时，上压板相对于基座可移动，以及连接两个凸轮构件的联动装置，使得两个凸轮构件相对于每个凸轮构件一致地移动 其他当启动时。

公开(公告)号：US07066083B2

公开(公告)日：2006-06-27

申请号：US10664011

申请日：2003-09-15

Applicant: Kevin L. Corcoran ,  David L. Hughes, Jr.

Inventor： Kevin L. Corcoran ,  David L. Hughes, Jr.

IPC: B30B9/32

CPC classification number: B26D7/0006 ,  B26D5/10 ,  B26D5/16 ,  B26F1/40 ,  B30B1/261 ,  Y10T83/6484

Abstract: Disclosed is a die press, comprising a base, opposing first and second supports extending from the base, at least one cam member that is supported by the opposing supports, means for rotating the cam member, at least one bearing located on the cam member, a platen positioned generally between the at least one bearing and the base, and a cover being unitary with the platen, the cover being slidably engaged with the opposing supports to guide the platen during operation of the die press.

公开(公告)号：USD472564S1

公开(公告)日：2003-04-01

申请号：US29159696

申请日：2002-04-26

Applicant: Kevin L. Corcoran ,  David L. Hughes, Jr. ,  Guorui Deng ,  Faye Angevine

Designer： Kevin L. Corcoran ,  David L. Hughes, Jr. ,  Guorui Deng ,  Faye Angevine

公开(公告)号：US06333435B1

公开(公告)日：2001-12-25

申请号：US08443616

申请日：1995-05-18

Applicant: Dongwei Cai ,  David L. Hughes ,  Sylvain Levac ,  Thomas R. Verhoeven

Inventor： Dongwei Cai ,  David L. Hughes ,  Sylvain Levac ,  Thomas R. Verhoeven

IPC: C07F902

CPC classification number: C07F9/5027

Abstract: A process of synthesizing a compound of the formula 1: is disclosed, which comprises reacting a compound of the formula 2: with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce a compound of formula 1.

Abstract translation: 公开了合成式1化合物的方法，其包括使式2化合物与二苯基膦在胺碱和镍催化剂的存在下反应以制备式1化合物。

公开(公告)号：US06262268B1

公开(公告)日：2001-07-17

申请号：US09709083

申请日：2000-11-09

Applicant: Michael Palucki ,  David L. Hughes ,  Chunhua Yang ,  Nobuyoshi Yasuda

Inventor： Michael Palucki ,  David L. Hughes ,  Chunhua Yang ,  Nobuyoshi Yasuda

IPC: C07D21338

CPC classification number: C07D213/40 ,  C07D213/38 ,  C07D471/04

Abstract: A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of &agr;v integrin receptor antagonists. Also provided are useful intermediates obtained from the process.

Abstract translation: 提供了一种制备3-（5,6,7,8-四氢 - [1,8] - 萘啶-2-基） - 丙胺的新方法，其可用于合成αphav整联蛋白受体拮抗剂。 还提供了从该方法获得的有用的中间体。

公开(公告)号：US4654433A

公开(公告)日：1987-03-31

申请号：US691086

申请日：1985-01-14

Applicant: David L. Hughes

Inventor： David L. Hughes

IPC: A61K20060101 ,  C07C20060101 ,  C07C101/77

CPC classification number: C07C227/18

Abstract: A simple single step process for preparing alkyl and substituted alkyl esters of amino acids is described. The products are bioactive compounds including compounds useful as antihypertensive agents.

Abstract translation: 描述了用于制备氨基酸的烷基和取代的烷基酯的简单的单步方法。 该产品是包括可用作抗高血压剂的化合物的生物活性化合物。

公开(公告)号：US06945166B2

公开(公告)日：2005-09-20

申请号：US10155706

申请日：2002-05-22

Applicant: Kevin L. Corcoran ,  Carl Von Hirsch ,  David L. Hughes, Jr.

Inventor： Kevin L. Corcoran ,  Carl Von Hirsch ,  David L. Hughes, Jr.

IPC: B26D5/16 ,  B26F1/40 ,  B30B1/12 ,  B30B1/14

CPC classification number: B26F1/40 ,  B26D5/16 ,  Y10T83/8838

Abstract: Disclosed is a die press with a base, at least two cam members spaced from the base, an upper platen located between the base and the two cam members to define a space for a die, the upper platen being generally parallel to the base, the upper platen also being attached to the two cam members so that when the two cam members are actuated, the upper platen is moveable relative to the base, and a linkage connecting the two cam members so that the two cam members move in unison relative to each other when actuated.

Abstract translation: 公开了一种具有底座的模压机，与基座间隔开的至少两个凸轮构件，位于基座和两个凸轮构件之间的上压板，以限定模具的空间，上压板大致平行于底座， 上压板也附接到两个凸轮构件，使得当两个凸轮构件被致动时，上压板相对于基座可移动，以及连接两个凸轮构件的联动装置，使得两个凸轮构件相对于每个凸轮构件一致地移动 其他当启动时。

公开(公告)号：US5892082A

公开(公告)日：1999-04-06

申请号：US813193

申请日：1997-03-07

Applicant: Dongwei Cai ,  Ian F. Cottrell ,  David L. Hughes ,  Joseph F. Payack

Inventor： Dongwei Cai ,  Ian F. Cottrell ,  David L. Hughes ,  Joseph F. Payack

IPC: B01J31/00 ,  B01J31/22 ,  C07F7/28 ,  C07F17/00 ,  C07F13/00

CPC classification number: B01J31/2295 ,  C07F17/00 ,  B01J2231/14 ,  B01J2231/4205 ,  B01J2531/46

Abstract: The present invention is directed to a process for the preparation of the reagent dimethyl titanocene (Cp.sub.2 Ti(CH.sub.3).sub.2) from titanocene dichloride (Cp.sub.2 TiCl.sub.2) and a methyl magnesium halide, in particular, methyl magnesium chloride (CH.sub.3 MgCl). The instant process provides the desired reagent in a manner which is generally less hazardous and more economical than previous methods.

Abstract translation: 本发明涉及二氯二茂钛（Cp2TiCl2）和甲基卤化镁，特别是甲基氯化镁（CH3MgCl）制备试剂二甲基二茂钛（Cp2Ti（CH3）2）的方法。 本方法以通常危险性较低且比以前方法更经济的方式提供所需试剂。

公开(公告)号：US5552521A

公开(公告)日：1996-09-03

申请号：US386618

申请日：1995-02-10

Applicant: Kevin M. Belyk ,  Dean R. Bender ,  Regina M. Black ,  David L. Hughes ,  William Leonard

Inventor： Kevin M. Belyk ,  Dean R. Bender ,  Regina M. Black ,  David L. Hughes ,  William Leonard

IPC: A61B17/04 ,  A61B17/06 ,  A61K38/00 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04 ,  C07K1/06 ,  C07K1/107 ,  C07K7/56 ,  C07K7/64

CPC classification number: C07K7/56 ,  A61B17/06133 ,  A61B2017/06142 ,  Y10S930/27

Abstract: There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.

Abstract translation: 公开了一种制备式（I）的氮杂环己肽的新方法，其中所有变量在本文中定义。

公开(公告)号：US5312923A

公开(公告)日：1994-05-17

申请号：US17922

申请日：1993-02-16

Applicant: John Y. L. Chung ,  David L. Hughes ,  Dalian Zhao

Inventor： John Y. L. Chung ,  David L. Hughes ,  Dalian Zhao

IPC: C07D211/22 ,  C07D213/30 ,  C07D211/02 ,  C07D211/82

CPC classification number: C07D213/30 ,  C07D211/22

Abstract: The invention is a highly efficient synthesis for making compounds of the formula: ##STR1## wherein: R.sup.1 is a six membered saturated or unsaturated heterocyclic ring containing one or two heteroatoms wherein the heteroatoms are N; or NR.sup.6, wherein R.sup.6 is H or C.sub.1-10 alkyl;m is an integer from two to six; andR.sup.4 is aryl, C.sub.1-10 alkyl, or C.sub.4-10 aralkyl.

Abstract translation: 本发明是制备下式的化合物的高效合成：其中：R1是含有一个或两个杂原子的六元饱和或不饱和杂环，其中杂原子是N; 或NR6，其中R6是H或C1-10烷基; m是二至六的整数; 和R 4是芳基，C 1-10烷基或C 4-10芳烷基。