公开(公告)号：US20230330441A1

公开(公告)日：2023-10-19

申请号：US18214386

申请日：2023-06-26

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  A61F7/00 ,  B06B1/02 ,  A61K9/00 ,  A61K41/00 ,  A61P35/00 ,  B06B1/06 ,  A61K31/197 ,  A61F7/02 ,  A61B18/00 ,  A61B17/32 ,  A61B17/00

CPC分类号： A61N7/00 ,  A61F7/0085 ,  B06B1/0207 ,  A61K9/0053 ,  A61K41/0033 ,  A61K41/0061 ,  A61P35/00 ,  B06B1/0622 ,  A61K31/197 ,  A61N2007/006 ,  B06B2201/76 ,  A61F2007/0288 ,  A61B2018/00023 ,  A61N2007/0078 ,  A61F2007/0056 ,  A61B2018/00446 ,  A61N2007/0095 ,  A61N2007/0073 ,  A61F2007/0096 ,  A61B2017/320069 ,  A61N2007/003 ,  A61N2007/0082 ,  A61B2017/00084

摘要： Disclosed are methods of producing randomized ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

公开(公告)号：US20230226379A1

公开(公告)日：2023-07-20

申请号：US18125971

申请日：2023-03-24

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  A61K9/00 ,  A61K31/197 ,  A61K41/00 ,  A61P35/00 ,  A61F7/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61N7/00 ,  A61K9/0053 ,  A61K31/197 ,  A61K41/0033 ,  A61K41/0061 ,  A61P35/00 ,  A61F7/0085 ,  B06B1/0207 ,  B06B1/0622 ,  A61B2017/00084

摘要： Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

公开(公告)号：US20230338753A1

公开(公告)日：2023-10-26

申请号：US18214421

申请日：2023-06-26

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  A61K9/00 ,  A61K31/197 ,  A61K41/00 ,  A61P35/00 ,  A61F7/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61N7/00 ,  A61K9/0053 ,  A61K31/197 ,  A61K41/0033 ,  A61K41/0061 ,  A61P35/00 ,  A61F7/0085 ,  B06B1/0207 ,  B06B1/0622 ,  A61B2017/00084

摘要： Disclosed are methods of using focused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

公开(公告)号：US20230330443A1

公开(公告)日：2023-10-19

申请号：US18215525

申请日：2023-06-28

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61N7/02

CPC分类号： A61N7/02 ,  A61N2007/0078

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

公开(公告)号：US20230330442A1

公开(公告)日：2023-10-19

申请号：US18215497

申请日：2023-06-28

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61N7/00 ,  A61K41/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61N7/00 ,  A61K41/0033 ,  B06B1/0215 ,  B06B1/0625 ,  A61N2007/0078 ,  B06B2201/76

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

公开(公告)号：US20220257984A1

公开(公告)日：2022-08-18

申请号：US17733868

申请日：2022-04-29

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  A61K9/00 ,  A61K31/197 ,  A61K41/00 ,  B06B1/02 ,  B06B1/06 ,  A61P35/00 ,  A61F7/00

摘要： Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

公开(公告)号：US20240293683A1

公开(公告)日：2024-09-05

申请号：US18656122

申请日：2024-05-06

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  A61B17/00 ,  A61B17/32 ,  A61B18/00 ,  A61F7/00 ,  A61F7/02 ,  A61K9/00 ,  A61K31/197 ,  A61K41/00 ,  A61M21/00 ,  A61M21/02 ,  A61P35/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61N7/00 ,  A61F7/0085 ,  A61K9/0053 ,  A61K31/197 ,  A61K41/0033 ,  A61K41/0061 ,  A61M21/02 ,  A61P35/00 ,  B06B1/0207 ,  B06B1/0622 ,  A61B2017/00084 ,  A61B2017/320069 ,  A61B2018/00023 ,  A61B2018/00446 ,  A61F2007/0056 ,  A61F2007/0096 ,  A61F2007/0288 ,  A61M2021/0027 ,  A61M2021/005 ,  A61N2007/003 ,  A61N2007/006 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0082 ,  A61N2007/0095 ,  B06B2201/76

摘要： Disclosed are systems and methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

公开(公告)号：US20240108917A1

公开(公告)日：2024-04-04

申请号：US18540651

申请日：2023-12-14

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  A61F7/00 ,  A61K9/00 ,  A61K31/197 ,  A61K41/00 ,  A61P35/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61N7/00 ,  A61F7/0085 ,  A61K9/0053 ,  A61K31/197 ,  A61K41/0033 ,  A61K41/0061 ,  A61P35/00 ,  B06B1/0207 ,  B06B1/0622 ,  A61B2017/00084

摘要： Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate as compounds such as a protoporphyrin compound in tumor cells. After such accumulation, such compounds are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

公开(公告)号：US20240024649A1

公开(公告)日：2024-01-25

申请号：US18040610

申请日：2021-08-04

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61M37/00 ,  A61N7/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61M37/0092 ,  A61N7/00 ,  B06B1/0215 ,  B06B1/0625 ,  A61N2007/0086 ,  B06B2201/55 ,  B06B2201/76

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

公开(公告)号：US20210370103A1

公开(公告)日：2021-12-02

申请号：US17400011

申请日：2021-08-11

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING

IPC分类号： A61N7/00 ,  B06B1/06 ,  B06B1/02

摘要： Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.