公开(公告)号：US20240024649A1

公开(公告)日：2024-01-25

申请号：US18040610

申请日：2021-08-04

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61M37/00 ,  A61N7/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61M37/0092 ,  A61N7/00 ,  B06B1/0215 ,  B06B1/0625 ,  A61N2007/0086 ,  B06B2201/55 ,  B06B2201/76

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

公开(公告)号：US20230338754A1

公开(公告)日：2023-10-26

申请号：US18215515

申请日：2023-06-28

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61K41/00 ,  B06B1/06 ,  A61N7/00

CPC分类号： A61N7/00 ,  A61K41/0033 ,  B06B1/0629 ,  B06B1/0633 ,  A61N2007/0043 ,  A61N2007/0078 ,  B06B2201/76

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

公开(公告)号：US20230330443A1

公开(公告)日：2023-10-19

申请号：US18215525

申请日：2023-06-28

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61N7/02

CPC分类号： A61N7/02 ,  A61N2007/0078

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

公开(公告)号：US20230330442A1

公开(公告)日：2023-10-19

申请号：US18215497

申请日：2023-06-28

申请人： Alpheus Medical, Inc.

发明人： Vijay AGARWAL ,  Braden ELIASON ,  Jeremy LING ,  John BALLARD ,  Gregg MILLER

IPC分类号： A61N7/00 ,  A61K41/00 ,  B06B1/02 ,  B06B1/06

CPC分类号： A61N7/00 ,  A61K41/0033 ,  B06B1/0215 ,  B06B1/0625 ,  A61N2007/0078 ,  B06B2201/76

摘要： Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.