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1.发明申请公开(公告)号：US20200337298A1
公开(公告)日：2020-10-29
申请号：US16916514
申请日：2020-06-30
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Paul LEZBERG , Giovanni CECERE , Dennis SOUSA , Elizabeth (Hansen) BULGER
IPC分类号： A01N1/02
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
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公开(公告)号：US20150342177A1
公开(公告)日：2015-12-03
申请号：US14728771
申请日：2015-06-02
申请人： TRANSMEDICS, INC
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Jeff BARNES , Greg RITCHIE , Richard BRINGHAM , Mark ANDERSON , John SULLIVAN
IPC分类号： A01N1/02
CPC分类号： A01N1/0247
摘要： The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
摘要翻译： 本发明一般涉及离体器官护理的系统，方法和装置。 更具体地，在各种实施方案中，本发明涉及在生理或近生理学条件下离体照料肝脏。
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3.发明申请公开(公告)号：US20190261626A1
公开(公告)日：2019-08-29
申请号：US16396296
申请日：2019-04-26
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Paul LEZBERG , Giovanni CECERE , Dennis SOUSA , Elizabeth (Hansen) BULGER
IPC分类号： A01N1/02
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
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公开(公告)号：US20190021308A1
公开(公告)日：2019-01-24
申请号：US16130255
申请日：2018-09-13
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Jeff BARNES , Greg RITCHIE , Richard BRINGHAM , Mark ANDERSON , John SULLIVAN
IPC分类号： A01N1/02
摘要： The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
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公开(公告)号：US20240292831A1
公开(公告)日：2024-09-05
申请号：US18402476
申请日：2024-01-02
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Jeff BARNES , Greg RITCHIE , Richard BRINGHAM , Mark ANDERSON , John SULLIVAN
IPC分类号： A01N1/02
CPC分类号： A01N1/0247
摘要： The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.
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公开(公告)号：US20240164370A1
公开(公告)日：2024-05-23
申请号：US18396196
申请日：2023-12-26
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Ahmed ELBETANONY , Richard BRINGHAM , Robert HAVENER , Vincent LAMBERT, II , Burt OCHS
CPC分类号： A01N1/0247 , A01N1/0294 , A61N1/046 , A61N1/0488 , A61N1/0492
摘要： The disclosure provides for electrode systems and perfusion systems that may be configured to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems may maintain the heart in a beating state at, or near, normal physiological conditions; circulate oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure, and/or flow rate. These systems may include a pair of electrodes that may be placed epicardially on the right atrium and/or left ventricle of the explanted heart, and/or an electrode placed in the aortic blood path.
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7.发明公开公开(公告)号：US20230210104A1
公开(公告)日：2023-07-06
申请号：US18153391
申请日：2023-01-12
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Paul LEZBERG , Giovanni CECERE , Dennis SOUSA , Elizabeth Hansen BULGER
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0273
摘要： The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell’s unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
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公开(公告)号：US20220232823A1
公开(公告)日：2022-07-28
申请号：US17722998
申请日：2022-04-18
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Jeff BARNES , Greg RITCHIE , Richard BRINGHAM , Mark ANDERSON , John SULLIVAN
IPC分类号： A01N1/02
摘要： The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.
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公开(公告)号：US20190269125A1
公开(公告)日：2019-09-05
申请号：US16418250
申请日：2019-05-21
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Ahmed ELBETANONY , Richard BRINGHAM , Robert HAVENER , Vincent LAMBERT, II , Burt OCHS
摘要： Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
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10.发明申请公开(公告)号：US20180153158A1
公开(公告)日：2018-06-07
申请号：US15857953
申请日：2017-12-29
申请人： TransMedics, Inc.
发明人： Waleed H. HASSANEIN , Tamer I. KHAYAL , Ahmed ELBETANONY , Paul LEZBERG , Giovanni CECERE , Dennis SOUSA , Elizabeth HANSEN
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/02
摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
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