公开(公告)号：US20150342177A1

公开(公告)日：2015-12-03

申请号：US14728771

申请日：2015-06-02

申请人： TRANSMEDICS, INC

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Ahmed ELBETANONY ,  Jeff BARNES ,  Greg RITCHIE ,  Richard BRINGHAM ,  Mark ANDERSON ,  John SULLIVAN

IPC分类号： A01N1/02

CPC分类号： A01N1/0247

摘要： The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

摘要翻译： 本发明一般涉及离体器官护理的系统，方法和装置。 更具体地，在各种实施方案中，本发明涉及在生理或近生理学条件下离体照料肝脏。

公开(公告)号：US20190021308A1

公开(公告)日：2019-01-24

申请号：US16130255

申请日：2018-09-13

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Ahmed ELBETANONY ,  Jeff BARNES ,  Greg RITCHIE ,  Richard BRINGHAM ,  Mark ANDERSON ,  John SULLIVAN

IPC分类号： A01N1/02

摘要： The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

公开(公告)号：US20130157248A1

公开(公告)日：2013-06-20

申请号：US13765009

申请日：2013-02-12

申请人： TRANSMEDICS, INC

发明人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer I. KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed H. HASSANEIN

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US20240292831A1

公开(公告)日：2024-09-05

申请号：US18402476

申请日：2024-01-02

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Ahmed ELBETANONY ,  Jeff BARNES ,  Greg RITCHIE ,  Richard BRINGHAM ,  Mark ANDERSON ,  John SULLIVAN

IPC分类号： A01N1/02

CPC分类号： A01N1/0247

摘要： The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.

公开(公告)号：US20220232823A1

公开(公告)日：2022-07-28

申请号：US17722998

申请日：2022-04-18

申请人： TransMedics, Inc.

发明人： Waleed H. HASSANEIN ,  Tamer I. KHAYAL ,  Ahmed ELBETANONY ,  Jeff BARNES ,  Greg RITCHIE ,  Richard BRINGHAM ,  Mark ANDERSON ,  John SULLIVAN

IPC分类号： A01N1/02

摘要： The disclosure generally relates to a system for perfusing an ex-vivo liver including a pump configured to pump a perfusion fluid through a perfusion circuit, the pump in fluid communication with a hepatic artery interface and a portal vein interface; an oxygenator; a heater; an inferior vena cava interface in fluid communication with an inferior vena cava of the ex-vivo liver; and a reservoir configured to receive the perfusion fluid from the inferior vena cava of the ex-vivo liver and store a volume of fluid.