公开(公告)号：US20240342222A1

公开(公告)日：2024-10-17

申请号：US18583572

申请日：2024-02-21

申请人： Regents of the University of Minnesota

发明人： Michael J. SADOWSKY ,  Alexander KHORUTS ,  Alexa R. WEINGARDEN ,  Matthew J. HAMILTON

IPC分类号： A61K35/37 ,  A61K9/00 ,  A61K9/16 ,  A61K35/00 ,  A61K35/24 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K45/06 ,  A61K47/08 ,  A61K47/26

CPC分类号： A61K35/37 ,  A61K9/0053 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1623 ,  A61K35/24 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K45/06 ,  A61K47/08 ,  A61K47/26 ,  A61K2035/11 ,  Y02A50/30

摘要： The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.

公开(公告)号：US20240335387A1

公开(公告)日：2024-10-10

申请号：US18292804

申请日：2021-08-05

申请人： ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

发明人： Tengfei Liu ,  Jialei Fang ,  Yanan Wang ,  Laiyi Ni

IPC分类号： A61K9/19 ,  A61K9/00 ,  A61K9/16 ,  A61K31/495

CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K31/495

摘要： Provided are a lyophilized vortioxetine pamoate powder for injection and a preparation method therefor. The prepared powder for injection product has good permeability and stability, and is very suitable for industrialization.

公开(公告)号：US12102621B2

公开(公告)日：2024-10-01

申请号：US17001793

申请日：2020-08-25

申请人： Loxo Oncology, Inc.

发明人： Mark Reynolds ,  Charles Todd Eary

IPC分类号： A61K31/439 ,  A61K9/00 ,  A61K9/08 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K31/498 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61P35/00

CPC分类号： A61K31/439 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/4825 ,  A61K31/498 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61P35/00

摘要： 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile, or a pharmaceutically acceptable salt, amorphous form, polymorph form, or pharmaceutical composition (including solid formulations or liquid formulations) thereof and the use thereof for treating diseases and disorders which can be treated with a RET kinase inhibitor, such as RET-associated diseases and disorders, e.g., proliferative disorders such as cancers, including hematological cancers and solid tumors, and gastrointestinal disorders such as IBS are disclosed.

公开(公告)号：US20240261227A1

公开(公告)日：2024-08-08

申请号：US18561351

申请日：2022-06-01

申请人： Michael OGBURN ,  Christopher PRICE

发明人： Michael OGBURN ,  Christopher PRICE

IPC分类号： A61K9/50 ,  A61K9/00 ,  A61K9/16 ,  A61K31/137 ,  A61K38/28

CPC分类号： A61K9/5047 ,  A61K9/0075 ,  A61K9/1623 ,  A61K31/137 ,  A61K38/28

摘要： Provided herein are pharmaceutical compositions, kits comprising pharmaceutical compositions, methods of treating disease, and methods of making compositions and kits described herein. The pharmaceutical compositions described herein are powdery pharmaceutical compositions. The powdery pharmaceutical compositions may be administered by an inhaler device described herein. The powdery pharmaceutical compositions can comprise encapsulated epinephrine or encapsulated insulin.

公开(公告)号：US12053537B2

公开(公告)日：2024-08-06

申请号：US15773767

申请日：2015-11-15

申请人： Symrise AG

发明人： Gerhard Schmaus ,  Sabine Lange ,  Eric Gruber

IPC分类号： A61K8/34 ,  A61K8/02 ,  A61K8/04 ,  A61K8/60 ,  A61K8/73 ,  A61K8/92 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K9/16 ,  A61K31/047 ,  A61K47/02 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61Q19/00 ,  A61Q19/02

CPC分类号： A61K8/347 ,  A61K8/022 ,  A61K8/046 ,  A61K8/60 ,  A61K8/732 ,  A61K8/922 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/107 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1658 ,  A61K31/047 ,  A61K47/02 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61Q19/00 ,  A61Q19/005 ,  A61K2800/10 ,  A61K2800/31 ,  A61K2800/56 ,  A61K2800/75 ,  A61Q19/02

摘要： The present invention belongs to the area of cosmetics that comprise at least an active agent which cause stinging, pricking, tingling and burning sensation on skin as a side effect. The invention in particular relates to a spray dried composition and the method as well as the use of the spray dried composition comprising said stinging, pricking, tingling and burning active agents to reduce and/or inhibit stinging, pricking, tingling and burning sensation on skin.

公开(公告)号：US20240226015A9

公开(公告)日：2024-07-11

申请号：US18372556

申请日：2023-09-25

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Theodore Randolph ,  Robert Garcea

IPC分类号： A61K9/19 ,  A61K9/16 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00

CPC分类号： A61K9/19 ,  A61K9/1623 ,  A61K9/1694 ,  A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  C12N7/00 ,  A61K2039/5258

摘要： Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lyophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

公开(公告)号：US20240207194A1

公开(公告)日：2024-06-27

申请号：US18598435

申请日：2024-03-07

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Hunter Chen ,  Scott Walsh

IPC分类号： A61K9/50 ,  A61K9/14 ,  A61K9/16 ,  A61K38/17 ,  A61P27/02

CPC分类号： A61K9/5089 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/5031 ,  A61K9/5047 ,  A61K38/179 ,  A61P27/02 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1652

摘要： Microparticles containing a core of therapeutic protein and a cortex of a biocompatible and biodegradable polymer, and methods of making and using the microparticles are provided. The extended release of a therapeutic protein from the microparticles in a physiological solution is demonstrated over an extended period of time.

公开(公告)号：US12018091B2

公开(公告)日：2024-06-25

申请号：US17083163

申请日：2020-10-28

申请人： Genentech, Inc.

发明人： Nicholas J. Armstrong ,  Mayumi N. Bowen ,  Yuh-Fun Maa

IPC分类号： C07K16/40 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K39/395 ,  C07K16/22 ,  C07K16/28 ,  C07K16/32

CPC分类号： C07K16/40 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/1623 ,  A61K9/1694 ,  A61K39/39541 ,  A61K39/3955 ,  C07K16/22 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/21

摘要： The present application discloses high-concentration monoclonal antibody formulations suitable for subcutaneous administration, e.g. via a pre-filled syringe. In particular, it discloses a formulation comprising a spray dried monoclonal antibody at a concentration of about 200 mg/mL or more suspended in a non-aqueous suspension vehicle where the viscosity of the suspension vehicle is less than about 20 centipoise. Also disclosed are: a subcutaneous administration device with the formulation therein, a method of making the formulation, a method of making an article of manufacture comprising the suspension formulation, use of the formulation in the preparation of a medicament, and a method of treating a patient with the formulation.

公开(公告)号：US20240197696A1

公开(公告)日：2024-06-20

申请号：US18463498

申请日：2023-09-08

申请人： Deciphera Pharmaceuticals, LLC

发明人： Michael D. Kaufman ,  Scott Bone ,  Corey Bloom ,  Fred Jordan

IPC分类号： A61K31/4375 ,  A61K9/16 ,  A61K9/20

CPC分类号： A61K31/4375 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2077

摘要： Provided herein is an amorphous compound represented by Formula (I):




and compositions thereof, which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.

公开(公告)号：US20240180940A1

公开(公告)日：2024-06-06

申请号：US18562719

申请日：2022-05-26

申请人： Revelation Biosciences, Inc.

发明人： James M. Rolke ,  Jackson R. Stephens ,  Joseph M. Ninosky

IPC分类号： A61K31/7024 ,  A61K9/107 ,  A61K9/16 ,  A61K47/10

CPC分类号： A61K31/7024 ,  A61K9/1075 ,  A61K9/1623 ,  A61K9/1652 ,  A61K47/10

摘要： Disclosed are pharmaceutical compositions of monophosphoryl lipid A (MPLA) like compounds, as well as methods of preparing such pharmaceutical compositions, and method of use for such compositions in treating allergic disease.