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公开(公告)号：US20240138400A1
公开(公告)日：2024-05-02
申请号：US18279639
申请日：2022-03-01
Inventor： Ho Nam Chan , Yiwei Shu
IPC: A01N1/02
CPC classification number: A01N1/0242
Abstract: Disclosed in the present invention is a biochip for cryopreservation or thawing and resuscitation of biological tissue, with four ends of the biochip being of a closed structure. The biochip includes: a section region, which is arranged in the middle and includes a plurality of sequentially arranged sections, with partition plates being provided between the sections, and the bottom of each section being provided with a fixing groove; and joint portions arranged on two sides of the section region. In the biochip having four ends being of a closed structure as provided in the present invention, a hydrogel or solution can be encapsulated in the plurality of sections of the biochip, such that the device is simple to operate and can effectively improve the efficiency of cryopreservation or thawing and resuscitation of embryos.
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公开(公告)号：US11918541B2
公开(公告)日：2024-03-05
申请号：US17353334
申请日：2021-06-21
Applicant: Biosafe S.A.
Inventor： Julien Pierre Camisani , Olivier Waridel
IPC: A61J1/20 , A01N1/02 , A61J1/10 , A61J1/16 , A61M1/02 , B01F25/42 , B01F31/55 , B01F35/513 , B01F35/90 , B01F35/92 , B01F101/23
CPC classification number: A61J1/2003 , A01N1/0242 , A61J1/10 , A61J1/165 , A61M1/025 , B01F25/42 , B01F31/55 , B01F35/513 , B01F35/92 , A61M2205/36 , B01F2035/99 , B01F2101/23
Abstract: A device and a method for mixing a fluid in a specimen bag is provided herein. In one embodiment, the device includes a mechanism for creating a first vortex and a second vortex. The first vortex is on a first side of a bag containing the fluid, and the second vortex is on a second side of the bag. The mechanism includes a first inflatable airbag and a second inflatable airbag. The first inflatable airbag is configured to create the first vortex when inflated and the second inflatable airbag is deflated. The second inflatable airbag is configured to create the second vortex when inflated and the first inflatable airbag is deflated.
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公开(公告)号：US20230389539A1
公开(公告)日：2023-12-07
申请号：US18325712
申请日：2023-05-30
Applicant: Fenwal, Inc.
Inventor： Craig L. Sandford
IPC: A01N1/02
CPC classification number: A01N1/0242 , A01N1/0226
Abstract: Systems for the prolonged storage of red blood cells (RBCs) are disclosed. The system includes a container made of a polymeric composition including polyvinyl chloride and a mixture of two or more hemolysis suppressing agents, and a storage medium that includes a fat emulsion entrained therein.
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公开(公告)号：US20230371500A1
公开(公告)日：2023-11-23
申请号：US18245382
申请日：2021-09-15
Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
Inventor： Alan W. FLAKE , Marcus Graeme DAVEY , Joshua MARTIN , Dana ZITNICK , Spencer BROWN , Dustin GAIDOS , Joseph GORDON
CPC classification number: A01N1/0231 , A61G11/00 , A01N1/0226 , A01N1/0242
Abstract: Systems and methods are disclosed relating to extracorporeal fetal care. A fetal chamber assembly configured to enclose and support a fetus therein includes a base configured to receive the fetus therein; a lid configured to removably contact the base to form a liquid-tight seal between the lid and the base; a growth chamber defined between the base and the lid, the growth chamber being configured to receive the fetus therein; and a cannulation chamber in fluid communication with the growth chamber, the cannulation chamber being configured to receive therein a cannulated umbilical cord of the fetus. The growth chamber is configured to be adjusted in size to accommodate the fetus during gestation based on the size of the fetus, and the fetal chamber assembly is configured to receive a liquid from a liquid source.
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公开(公告)号：US11723357B2
公开(公告)日：2023-08-15
申请号：US17530037
申请日：2021-11-18
Applicant: TransMedics, Inc.
Inventor： Waleed H. Hassanein , Richard Bringham , Giovanni Cecere , Tamer I. Khayal , Ronald Taylor, Jr. , Hossam Algamil
IPC: A01N1/02
CPC classification number: A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
Abstract: The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near physiologic conditions. In certain embodiments, the disclosure relates to testing properties of an ex-vivo heart or an organ care system, adjusting a property of the organ care system in response to certain results of the testing, and re-testing the ex-vivo heart or the organ care system. In certain embodiments, the disclosure relates to synchronizing at least one cycle of a pumping of a perfusion fluid with a state of the ex-vivo heart.
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公开(公告)号：US20190246630A1
公开(公告)日：2019-08-15
申请号：US16396059
申请日：2019-04-26
Applicant: TransMedics, Inc.
Inventor： Waleed H. HASSANEIN , Richard BRINGHAM , Giovanni CECERE , Tamer I. KHAYAL , Ronald TAYLOR, Jr. , Hossam ALGAMIL
IPC: A01N1/02
CPC classification number: A01N1/0242 , A01N1/02 , A01N1/0226 , A01N1/0247
Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
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公开(公告)号：US20190231948A1
公开(公告)日：2019-08-01
申请号：US16336950
申请日：2017-09-26
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Masatsugu IGARASHI
CPC classification number: A61M1/0209 , A01N1/0242 , A61M1/0218 , A61M1/0272 , A61M1/0295
Abstract: Provided are a blood bag system and a blood treatment method capable of securely and efficiently obtaining a medium specific gravity blood component having a sufficiently low content rate of a light specific gravity blood component.In a blood bag system (10) used for a blood treatment method, in a transfer completed state in which whole blood in a first bag (12) is centrifuged to transfer blood plasma to a second bag (14) through a first transfer tube (24) and transfer red cell concentrates to a third bag (16) through a second transfer tube (26), a buffy coat is left in the first bag (12). In the transfer completed state, when a platelet added solution is transferred from a fourth bag (18) to the first bag (12) on which a centrifugal force acts through a third transfer tube (28), blood plasma in the buffy coat is discharged from the first bag (12).
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公开(公告)号：US20190183114A1
公开(公告)日：2019-06-20
申请号：US16322159
申请日：2017-08-04
Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite de Poitiers , Centre Hospitalier Universitaire de Poitiers
Inventor： Thierry HAUET , Sylvain LE PAPE , Raphael THUILLIER, II
IPC: A01N1/02 , C12N15/113
CPC classification number: A01N1/0278 , A01N1/0226 , A01N1/0242 , C12N15/113
Abstract: The present invention relates to methods and compositions for the preservation of organs. The inventors showed that therapeutic intervention during cold ischemia could significantly alter outcome, suggesting active mechanisms taking place. More particularly, the inventors demonstrated that Unfolded Protein Response could be a critical pathway underlying the relationship between cold ischemia time and graft outcome, highlighting the potential for UPR-based therapeutics to improve transplantation efficiency. In particular, the present invention relates to an activator of PERK-ATF4 pathway, an inhibitor of the ATF6 pathway and an inhibitor of the RNase activity of IRE1α for use in the maintain of organ viability during cold ischemia.
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公开(公告)号：US20180352807A1
公开(公告)日：2018-12-13
申请号：US16002795
申请日：2018-06-07
Applicant: Paragonix Technologies, Inc.
Inventor： Jared Alden Judson , Lisa Maria Anderson , William Edelman
IPC: A01N1/02
CPC classification number: A01N1/0242
Abstract: Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially lung tissue, through the use of an expandable accumulator to maintain a constant pressure within the lumen of the organ even during external pressure fluctuations due to, for example, flight. Systems and methods may include prolonging donor organ viability in storage through the use of an organ container that mimics the geometry and orientation of the organ in vivo.
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10.发明申请
公开(公告)号：US20180332842A1
公开(公告)日：2018-11-22
申请号：US15692520
申请日：2017-08-31
Applicant: DROBOT BIOTECHNOLOGY LIMITED COMPANY
Inventor： Chia-Kang TSAO
IPC: A01N1/02 , A01K67/033
CPC classification number: A01N1/0263 , A01K67/033 , A01N1/0242 , C12M21/00 , C12M23/08 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/50 , C12M33/04 , C12M41/48
Abstract: A culture container includes a tube having a first and a second opening respectively provided at two opposite ends thereof, and a cover attachable to and removable from the first opening of the tube, the cover including an inlet port for passage of a fluid substance and a receptacle for holding a substance consumable by an organism of interest, the receptacle being enclosed inside the tube and the inlet port communicating with a hollow interior of the tube when the cover is attached to the first opening of the tube. Moreover, a system and a method of transferring a cultured organism of interest include switching the covers between two culture containers.
