公开(公告)号：US12053489B2

公开(公告)日：2024-08-06

申请号：US17954091

申请日：2022-09-27

申请人： Alkahest, Inc.

发明人： Viktoria Kheifets ,  Benson Lu

IPC分类号： A61K35/16 ,  A61P1/16

CPC分类号： A61K35/16 ,  A61P1/16

摘要： Methods and compositions for treating aging-related diseases as well as liver regeneration, prevention of liver degeneration, and maintenance of liver are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing disease.

公开(公告)号：US12017211B2

公开(公告)日：2024-06-25

申请号：US17929626

申请日：2022-09-02

申请人： Hanuman Pelican, Inc.

发明人： Randy Dorian ,  Michael D. Leach ,  Richard W. Storrs ,  Scott R. King

IPC分类号： B01L3/00 ,  A61K8/98 ,  A61K35/16 ,  A61K35/19 ,  A61Q7/00 ,  A61Q19/08 ,  B01D21/26 ,  B04B5/04

CPC分类号： B01L3/50215 ,  A61K8/983 ,  A61K35/16 ,  A61K35/19 ,  A61Q7/00 ,  A61Q19/08 ,  B01D21/262 ,  B01L3/505 ,  B04B5/0414 ,  B01L2300/042 ,  B01L2300/0832 ,  B01L2300/123 ,  B01L2300/16

摘要： Apparatus and methods for separating blood components are disclosed in which an apparatus for separating blood generally includes a tube defining a channel and configured for receiving a quantity of blood and a float contained within the tube and having a density which is predefined so that the float is maintained at equilibrium between a first layer formed from a first fractional component of the blood and a second layer formed from a second fractional component of the blood. Upon completion of the centrifugation, the first layer may be removed from the tube while the float isolates the second layer from the first layer.

公开(公告)号：US20240181140A1

公开(公告)日：2024-06-06

申请号：US17797074

申请日：2022-04-06

申请人： PRP TECHNOLOGIES INC

发明人： Marcin Kowalewski ,  Ryszard Kowalewski

IPC分类号： B01L3/00 ,  A61K35/16 ,  A61M1/02 ,  A61M1/34 ,  B01D21/26

CPC分类号： B01L3/50215 ,  A61K35/16 ,  A61M1/029 ,  A61M1/3482 ,  A61M1/3496 ,  B01D21/26 ,  B01L3/5021

摘要： Method for transferring one or more portions of fluid from a specimen tube, comprising: providing an elongate connector comprising an elongated tube having a lumen or through-hole extending between proximal and distal ends thereof, a Luer-compatible female taper provided on the proximal end of the connector, a flange provided proximate the distal end of the connector; providing a tube seal mounted on the distal end of the connector, the tube seal comprising an elastomeric member having a longitudinal axis, a proximal end, a distal end, and a through-hole extending therebetween, the distal end having a frustoconical or chamfered face forming a funnel, the elastomeric member having an outer diameter sized to sealingly engage with an inner surface of the specimen tube; advancing the distal end of the connector and the tube seal into the specimen tube, the funnel directing the first layer into the through-hole of the connector.

公开(公告)号：US20240173351A1

公开(公告)日：2024-05-30

申请号：US18326924

申请日：2023-05-31

申请人： Cerus Corporation

发明人： Laurence CORASH ,  Richard BENJAMIN ,  Elan WEINER ,  Johannes VERMEIJ

IPC分类号： A61K35/16 ,  A61K9/00 ,  A61P7/00

CPC分类号： A61K35/16 ,  A61K9/0019 ,  A61P7/00

摘要： Provided herein are pathogen-inactivated plasma compositions and methods for treating a disease or condition using pathogen-inactivated plasma compositions.

公开(公告)号：US20240123367A1

公开(公告)日：2024-04-18

申请号：US18097352

申请日：2023-01-16

申请人： Velico Medical, Inc.

发明人： Robert R. Andrews ,  Herman E. Snyder ,  William J. Merritt ,  Evan P. Ordway ,  Clair Strohl

IPC分类号： B01D1/18 ,  A61J1/00 ,  A61J3/00 ,  A61K9/16 ,  A61K35/16 ,  B01D1/00 ,  B01J2/04

CPC分类号： B01D1/18 ,  A61J1/00 ,  A61J3/00 ,  A61K9/16 ,  A61K35/16 ,  B01D1/0082 ,  B01J2/04

摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

公开(公告)号：US20240115760A1

公开(公告)日：2024-04-11

申请号：US18512129

申请日：2023-11-17

申请人： Ortho Regenerative Technologies Inc.

发明人： Caroline Hoemann ,  Daniel Veilleux ,  Michael D. Buschmann

IPC分类号： A61L27/20 ,  A61K9/00 ,  A61K9/19 ,  A61K31/721 ,  A61K31/722 ,  A61K35/16 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/37 ,  A61K38/48 ,  A61L27/02 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  C08B37/02 ,  C08B37/08 ,  C08L5/02 ,  C08L5/08

CPC分类号： A61L27/20 ,  A61K9/0024 ,  A61K9/19 ,  A61K31/721 ,  A61K31/722 ,  A61K35/16 ,  A61K38/1866 ,  A61K38/193 ,  A61K38/195 ,  A61K38/20 ,  A61K38/21 ,  A61K38/37 ,  A61K38/482 ,  A61K38/4833 ,  A61L27/025 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  C08B37/0021 ,  C08B37/003 ,  C08L5/02 ,  C08L5/08 ,  C12Y304/21005 ,  C12Y304/21059 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2430/06

摘要： The present application relates to a lyophilized scaffold composition having at least one polysaccharide wherein said scaffold is substantially solid and capable of being formed into a desired shape; wherein the at least one polysaccharide has a protonation level resulting in controlled rehydration of said scaffold, such that when said scaffold is contacted with at least one of a neutral aqueous solution, blood, blood derived fluid and combinations thereof, said scaffold forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair, a process for preparing a lyophilized scaffold composition and the use of a lyophilized scaffold composition for wound repair in a mammal.

公开(公告)号：US20240102730A1

公开(公告)日：2024-03-28

申请号：US18096645

申请日：2023-01-13

申请人： Velico Medical, Inc.

发明人： Robert R. Andrews ,  Herman E. Snyder ,  William J. Merritt ,  Evan P. Ordway ,  Clair Strohl ,  Russell Barron

IPC分类号： F26B3/12 ,  A61K35/16

CPC分类号： F26B3/12 ,  A61K35/16

摘要： The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

公开(公告)号：US11938174B2

公开(公告)日：2024-03-26

申请号：US17018954

申请日：2020-09-11

申请人： Takeda Pharmaceutical Company Limited

发明人： Colin Broom ,  Jeffrey Dayno

IPC分类号： A61K38/55 ,  A61K35/16 ,  A61K38/57 ,  A61K45/06 ,  A61K39/395 ,  C07K16/18 ,  C07K16/28

CPC分类号： A61K38/57 ,  A61K35/16 ,  A61K38/55 ,  A61K45/06 ,  A61K39/3955 ,  C07K16/18 ,  C07K16/28 ,  A61K35/16 ,  A61K2300/00 ,  A61K39/3955 ,  A61K2300/00

摘要： Compositions and methods useful for the treatment of neuromyelitis optica (NMO) or neuromyelitis optica spectrum disorder (NMOSD) are disclosed.

公开(公告)号：US11897943B2

公开(公告)日：2024-02-13

申请号：US17397915

申请日：2021-08-09

申请人： ADMA Biologics, Inc.

发明人： James Mond ,  Adam S. Grossman

IPC分类号： C07K16/12 ,  C07K16/06 ,  A61K9/00 ,  A61K35/16

CPC分类号： C07K16/1275 ,  A61K9/0019 ,  A61K35/16 ,  C07K16/06 ,  C07K16/065 ,  C07K2317/10 ,  C07K2317/21

摘要： The present invention relates to compositions and methods for the treatment of infection caused by Streptococcus pneumonia. In particular, the invention provides human hyperimmune globulin and compositions thereof for preventing or treating pneumococcal infection. The invention provides methods of producing hyperimmune globulin containing high titers of opsonophagocytic anti-pneumococcal antibodies, compositions containing same, and methods of using the compositions for the prevention and treatment of pneumococcal infection. The invention further provides methods of preventing or treating pneumococcal infection (e.g., upper respiratory infections (e.g., bronchitis, otitis, sinusitis, etc.)) in immunocompromised subjects via administration of hyperimmune globulin compositions of the invention (e.g., containing a high titer of opsonophagocytic anti-pneumococcal antibodies) to immunocompromised subjects.

公开(公告)号：US20240041936A1

公开(公告)日：2024-02-08

申请号：US18366516

申请日：2023-08-07

申请人： CREATIVE MEDICAL TECHNOLOGIES, INC.

发明人： Thomas ICHIM ,  Amit PATEL ,  Courtney BARTLETT

IPC分类号： A61K35/28 ,  A61K35/16 ,  A61N5/067 ,  C07K16/28 ,  A61K31/366 ,  A61K31/382 ,  A61K31/58 ,  A61K31/164

CPC分类号： A61K35/28 ,  A61K35/16 ,  A61N5/067 ,  C07K16/2887 ,  A61K31/366 ,  A61K31/382 ,  A61K31/58 ,  A61K31/164

摘要： Disclosed are means, methods and compositions of matter for prevention of hair loss and/or regeneration of hair follicles utilizing stem cell-based approaches and synergies with stimulating and/or hormone modulating agents. In one embodiment the invention discloses specific platelet rich plasma (PRP) combinations alone or with bone marrow stem cells to augment hair restoration and stimulate expansion of hair follicle associated T regulatory cell.