公开(公告)号：US20240173460A1

公开(公告)日：2024-05-30

申请号：US18514277

申请日：2023-11-20

申请人： David M. JACKSON ,  Board of Regents, The University of Texas System

发明人： George D. BITTNER ,  David M. JACKSON

IPC分类号： A61L27/50 ,  A61L27/02 ,  A61L27/04 ,  A61L27/38

CPC分类号： A61L27/50 ,  A61L27/025 ,  A61L27/047 ,  A61L27/383 ,  A61L2300/802 ,  A61L2430/32

摘要： The disclosure relates to defined solutions for organ (heart, liver, kidney, etc,) vascular composite allografts or autografts (VCA: hand, limb, face, etc.) or tissue (peripheral nerves, spinal cord, skin) storage that preserve the electrophysiological functions of axons contained therein. The disclosure also concerns the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft or allograft transplantation procedures, as well as the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft/allograft transplantation procedures in combination with the peripheral nerve repair techniques of neurorrhaphy and axonal fusion primarily using polyethylene glycol known as PEG-fusion.

公开(公告)号：US11964881B2

公开(公告)日：2024-04-23

申请号：US16939984

申请日：2020-07-27

申请人： NATIONAL CHIAO TUNG UNIVERSITY

发明人： Pu-Wei Wu ,  Yi-Chieh Hsieh ,  Han-Yi Wang ,  Kuang-Chih Tso ,  Tzu-Ying Chan ,  Chung-Kai Chang ,  Chi-Shih Chen ,  Yu-Ting Cheng

IPC分类号： C01G55/00 ,  A61L27/02 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： C01G55/004 ,  A61L27/025 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2004/64

摘要： A method for making iridium oxide nanoparticles includes dissolving an iridium salt to obtain a salt-containing solution, mixing a complexing agent with the salt-containing solution to obtain a blend solution, and adding an oxidating agent to the blend solution to obtain a product mixture. A molar ratio of a complexing compound of the complexing agent to the iridium salt is controlled in a predetermined range so as to permit the product mixture to include iridium oxide nanoparticles.

公开(公告)号：US20240009347A1

公开(公告)日：2024-01-11

申请号：US18372860

申请日：2023-09-26

申请人： DEPUY SYNTHES PRODUCTS, INC.

发明人： Rajendra Kasinath ,  Craig Ernsberger ,  Stephanie Vass ,  Steven N. Ginn ,  Haibo Qu ,  Weidong Tong

IPC分类号： A61L27/12 ,  A61L27/06 ,  A61L27/56 ,  A61L27/50 ,  A61L27/04 ,  A61L27/58 ,  A61L27/32 ,  A61L27/02

CPC分类号： A61L27/12 ,  A61L27/06 ,  A61L27/56 ,  A61L27/50 ,  A61L27/045 ,  A61L27/58 ,  A61L27/32 ,  A61L27/025 ,  A61L27/047

摘要： An orthopedic implant having a metal surface and a hydroxyapatite layer comprising gallium ions therein disposed on at least part of the metal surface is described. The hydroxyapatite layer has an average crystallite size of less than about 75 nm in at least one direction and dissolves for more than 2 hours in vitro. The hydroxyapatite layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

公开(公告)号：US11793991B2

公开(公告)日：2023-10-24

申请号：US17073085

申请日：2020-10-16

申请人： SummaCor, Inc.

发明人： Steve C. Smith ,  Brian A. Babson

IPC分类号： A61M60/419 ,  A61L27/02 ,  A61M60/139 ,  A61M60/13 ,  A61M60/562 ,  A61M60/89 ,  A61M60/268

CPC分类号： A61M60/139 ,  A61M60/13 ,  A61M60/268 ,  A61M60/562 ,  A61M60/89 ,  A61M2205/0216

摘要： Described herein are pumps that linearly reciprocate to assist with circulating blood within the body of a patient. Red blood cell damage may be avoided or minimized by such linear pump movement. The linearly reciprocating movement may also generate a pulsatile pumping cycle that mimics the natural pumping cycle of the heart. The pumps may be configured to reside at various body locations. For example, the pumps may be situated within the right ventricle, the left ventricle, the ascending aorta, the descending aorta, the thoracic aorta, or the abdominal aorta. In some instances, the pump may reside outside the patient.

公开(公告)号：US11730511B2

公开(公告)日：2023-08-22

申请号：US16669720

申请日：2019-10-31

申请人： SRGI HOLDINGS, LLC

发明人： Edward Knowlton

IPC分类号： A61B17/322 ,  A61L27/48 ,  A61B17/34 ,  A61B90/00 ,  A61F2/10 ,  A61B17/54 ,  A61B17/3209 ,  A61B17/3211 ,  A61M5/178 ,  A61F13/00 ,  A61F2/04 ,  A61L27/36 ,  A61L27/20 ,  A61L27/52 ,  A61L27/02 ,  A61L27/54 ,  A61B17/3205 ,  A61B17/32 ,  A61M5/46 ,  A61M35/00 ,  A61B17/00 ,  A61B18/00 ,  A61B17/30 ,  A61M37/00 ,  A61B10/02 ,  A61M19/00

CPC分类号： A61B17/322 ,  A61B17/32 ,  A61B17/3211 ,  A61B17/32053 ,  A61B17/320068 ,  A61B17/32093 ,  A61B17/3468 ,  A61B17/54 ,  A61B90/02 ,  A61F2/042 ,  A61F2/105 ,  A61F13/00 ,  A61L27/025 ,  A61L27/20 ,  A61L27/362 ,  A61L27/3691 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61M5/178 ,  A61M5/46 ,  A61M35/003 ,  A61B10/0233 ,  A61B2017/00752 ,  A61B2017/00761 ,  A61B2017/00792 ,  A61B2017/00884 ,  A61B2017/00951 ,  A61B2017/00969 ,  A61B2017/306 ,  A61B2017/32007 ,  A61B2017/3225 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2018/00601 ,  A61B2018/00994 ,  A61B2217/005 ,  A61F2002/044 ,  A61F2002/047 ,  A61F2013/0028 ,  A61F2013/00157 ,  A61L2300/414 ,  A61L2400/06 ,  A61M19/00 ,  A61M2037/0023 ,  A61L27/48 ,  C08L5/08 ,  A61L27/20 ,  C08L5/08

摘要： Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

公开(公告)号：US20230211044A1

公开(公告)日：2023-07-06

申请号：US17992527

申请日：2022-11-22

申请人： RevBio, Inc.

发明人： Brian J. Hess ,  George W. Kay

IPC分类号： A61L27/12 ,  A61L27/02 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61C5/70 ,  A61C5/35 ,  A61C8/00 ,  A61C13/271 ,  A61F2/28 ,  A61F2/44 ,  A61L24/00 ,  A61L24/02 ,  A61L27/36 ,  A61L27/58

CPC分类号： A61L27/12 ,  A61L27/02 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61C5/70 ,  A61C5/35 ,  A61C8/0009 ,  A61C13/26 ,  A61F2/2803 ,  A61F2/4455 ,  A61L24/0005 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/025 ,  A61L27/3604 ,  A61L27/3616 ,  A61L27/58 ,  A61L2430/12 ,  A61F2002/2835 ,  A61F2002/30448

摘要： The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

公开(公告)号：US11672885B2

公开(公告)日：2023-06-13

申请号：US15992996

申请日：2018-05-30

申请人： Abyrx, Inc.

发明人： Richard Kronenthal ,  John Pacifico ,  Aniq Darr

IPC分类号： A61L27/36 ,  A61L24/00 ,  A61L27/02 ,  A61L27/10 ,  A61L27/12 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  C08L33/12 ,  C08L33/14 ,  C08L71/02 ,  C08L75/04

CPC分类号： A61L27/3691 ,  A61L24/0005 ,  A61L27/025 ,  A61L27/10 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3616 ,  A61L27/3687 ,  A61L27/505 ,  A61L27/54 ,  A61L27/58 ,  C08L33/12 ,  C08L33/14 ,  C08L71/02 ,  C08L75/04 ,  A61L2400/04 ,  C08L2203/02

摘要： Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

公开(公告)号：US11596712B2

公开(公告)日：2023-03-07

申请号：US17215843

申请日：2021-03-29

申请人： Perform Biologies, Inc.

发明人： Slobodan Vukicevic ,  Kuber T. Sampath ,  Lovorka Grgurevic ,  Charles Cohen ,  Hermann Oppermann

IPC分类号： A61L27/36 ,  A61L27/26 ,  A61L27/12 ,  A61L27/54 ,  A61L27/02 ,  A61L27/46 ,  A61L27/44

摘要： An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects, a method of preparation thereof, and a method of inducing or promoting bone growth by treatment of a bone with an autologous bone graft substitute composition. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof; and a compression resistant matrix selected from the group consisting of a bone autograft, bone allograft, hydroxyapatite, tri-calcium phosphate, and combinations thereof. The autologous blood forms a coagulum gel comprising a fibrin-meshwork reinforced with the compression resistant matrix and containing the osteogenic bone morphogenetic protein which is released over a sustained period.

公开(公告)号：US20220370687A1

公开(公告)日：2022-11-24

申请号：US17664792

申请日：2022-05-24

申请人： Rutgers, The State University of New Jersey

发明人： Ki-Bum Lee ,  Letao Yang

IPC分类号： A61L27/56 ,  A61L27/02 ,  A61L27/14

摘要： A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.

公开(公告)号：US11446410B2

公开(公告)日：2022-09-20

申请号：US17076410

申请日：2020-10-21

申请人： CORNING INCORPORATED

发明人： Huayun Deng ,  Qiang Fu ,  John Christopher Mauro

IPC分类号： C03C10/04 ,  C03C10/12 ,  A61L27/10 ,  A61L24/02 ,  C03C21/00 ,  C03C10/00 ,  C03C10/16 ,  C03C4/00 ,  C03C4/18 ,  A61L24/00 ,  A61L27/12 ,  A61L27/04 ,  A61L27/02 ,  C03C3/097 ,  C03C3/118 ,  C03C3/112 ,  C03B25/02

摘要： A chemically strengthened bioactive glass-ceramic composition as defined herein. Also disclosed are methods of making and using the disclosed compositions.