公开(公告)号：US20220265519A1

公开(公告)日：2022-08-25

申请号：US17630711

申请日：2020-07-27

申请人： GEBR. BRASSELER GMBH & CO. KG

发明人： Helmut CÖLFEN ,  Elena STURM ,  Julian KONSEK ,  Michael KÜLLMER

IPC分类号： A61K6/864 ,  A61K6/60 ,  A61K6/78 ,  A61K6/853 ,  C04B12/02 ,  C04B14/28 ,  C04B28/02 ,  C04B24/14 ,  C04B28/34

摘要： According to the invention, a preparation is described which contains at least one calcium compound selected from the group consisting of calcium phosphates, calcium fluorides and calcium fluorophosphates and hydroxyl derivatives and carbonate derivatives of these calcium salts, calcium hydroxides and calcium oxides precipitated using at least one protein component selected from proteins and protein hydrolysates, and at least one crosslinking agent for the protein component and/or non-set cement.

公开(公告)号：US20210146004A1

公开(公告)日：2021-05-20

申请号：US17122816

申请日：2020-12-15

申请人： RevBio, Inc.

发明人： Brian J. Hess ,  George W. Kay

IPC分类号： A61L27/12 ,  A61L27/02 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61C5/70 ,  A61C5/35 ,  A61C8/00 ,  A61C13/271 ,  A61F2/28 ,  A61F2/44 ,  A61L24/00 ,  A61L24/02 ,  A61L27/36 ,  A61L27/58

摘要： The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

公开(公告)号：US11129774B2

公开(公告)日：2021-09-28

申请号：US16301773

申请日：2017-05-16

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Cameron Alexander Stewart ,  Benjamin David Hatton ,  Yoav Finer

IPC分类号： A61K8/14 ,  A61K6/84 ,  A61L27/56 ,  C07C279/26 ,  C07D213/74 ,  C07C279/14 ,  A61K31/4425 ,  A61K31/155 ,  C07D213/20 ,  A61K31/444 ,  A61L27/54 ,  A61K9/00 ,  A61L27/42 ,  A61L27/30 ,  A61L27/44 ,  A61K9/14 ,  A61P1/02 ,  A01N25/08 ,  A61P31/04 ,  A61P31/02 ,  A61K9/51 ,  A61L27/32 ,  A61K31/785 ,  A61L27/12 ,  A61L27/10 ,  A61L27/02 ,  A01N43/40 ,  A01N47/44 ,  A61K31/20 ,  A61K6/20 ,  A61K6/35 ,  A61K6/40 ,  A61K6/54 ,  A61K6/71 ,  A61K6/74 ,  A61K6/76 ,  A61K6/80 ,  A61K6/86 ,  A61K6/802 ,  A61K6/849 ,  A61K6/853 ,  A61K6/864 ,  A61K6/871 ,  C08K3/22 ,  C08K3/32 ,  C08L33/12

摘要： A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

公开(公告)号：US20210276869A1

公开(公告)日：2021-09-09

申请号：US17255522

申请日：2019-06-27

申请人： CURASEPT A.D.S. S.R.L.

发明人： Michele IAFISCO ,  Anna TAMPIERI

IPC分类号： C01B25/32 ,  A61K6/17 ,  A61K6/54 ,  A61K6/864

摘要： The invention relates to a process for the preparation of a citrate-coated amorphous calcium phosphate nanoparticle which comprises the following steps: 1) providing a first solution of a salt of calcium and a citrate salt wherein the molar ratio of citrate ion to calcium ion is in the range from 1 to 2 thus obtaining a clear first solution; 2) providing a second solution of a salt capable to give phosphate anion and a carbonate salt; 3) mixing together the first and the second solution at a pH in the range from 8 to 11; 4) precipitating the nanoparticle; and 5) drying the nanoparticle obtained from step 4). Preferably and advantageously the invention provides for the addition of a fluoride compound in step 2) for obtaining a fluorine-doped citrate-coated calcium phosphate nanoparticle or a nanoparticle agglomerate. The nanoparticle/nanoparticle agglomerate of the invention has a peculiar superficial area and a diameter that allow to use it as a biomaterial for dentistry application.

公开(公告)号：US20230211044A1

公开(公告)日：2023-07-06

申请号：US17992527

申请日：2022-11-22

申请人： RevBio, Inc.

发明人： Brian J. Hess ,  George W. Kay

IPC分类号： A61L27/12 ,  A61L27/02 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61C5/70 ,  A61C5/35 ,  A61C8/00 ,  A61C13/271 ,  A61F2/28 ,  A61F2/44 ,  A61L24/00 ,  A61L24/02 ,  A61L27/36 ,  A61L27/58

CPC分类号： A61L27/12 ,  A61L27/02 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61C5/70 ,  A61C5/35 ,  A61C8/0009 ,  A61C13/26 ,  A61F2/2803 ,  A61F2/4455 ,  A61L24/0005 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/025 ,  A61L27/3604 ,  A61L27/3616 ,  A61L27/58 ,  A61L2430/12 ,  A61F2002/2835 ,  A61F2002/30448

摘要： The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

公开(公告)号：US20220054364A1

公开(公告)日：2022-02-24

申请号：US17464211

申请日：2021-09-01

申请人： MESOSIL INC.

发明人： Cameron Alexander STEWART ,  Benjamin David HATTON ,  Yoav FINER

IPC分类号： A61K6/84 ,  A61L27/56 ,  C07C279/26 ,  C07D213/74 ,  C07C279/14 ,  A61K31/4425 ,  A61K31/155 ,  C07D213/20 ,  A61K31/444 ,  A61L27/54 ,  A61K9/00 ,  A61L27/42 ,  A61L27/30 ,  A61L27/44 ,  A61K9/14 ,  A61P1/02 ,  A01N25/08 ,  A61P31/04 ,  A61P31/02 ,  A61K9/51 ,  A61L27/32 ,  A61K31/785 ,  A61L27/12 ,  A61L27/10 ,  A61L27/02 ,  A01N43/40 ,  A01N47/44 ,  A61K31/20 ,  A61K6/20 ,  A61K6/35 ,  A61K6/40 ,  A61K6/54 ,  A61K6/71 ,  A61K6/74 ,  A61K6/76 ,  A61K6/80 ,  A61K6/86 ,  A61K6/802 ,  A61K6/849 ,  A61K6/853 ,  A61K6/864 ,  A61K6/871 ,  C08K3/22 ,  C08K3/32 ,  C08L33/12

摘要： A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

公开(公告)号：US10815144B2

公开(公告)日：2020-10-27

申请号：US16318064

申请日：2017-07-14

申请人： Mark Robert Towler ,  Adel Moh'd Fawzi A. R. Alhalawani

发明人： Mark Robert Towler ,  Adel Moh'd Fawzi A. R. Alhalawani

IPC分类号： C03C3/062 ,  A61L24/12 ,  C03C4/00 ,  A61K6/864 ,  A61K6/889 ,  C03C3/078 ,  C03C3/097 ,  C08L33/08

摘要： Various embodiments of tantalum- and/or niobium-containing glasses and cements as well as uses thereof are described herein. For example, in an embodiment, the glasses comprise a transition metal pentoxide such as tantalum pentoxide and/or niobium pentoxide present in the glass in an amount of less than 2.0 mol %, based on the total composition of the glass, glass polyalkenoate cements prepared from such glasses and uses of such cements, for example, for sternal closure or fixation, stabilization and/or repair of a fracture in a bone in the wrist, elbow, knee, shoulder, spine and/or hip.

公开(公告)号：US20240123114A1

公开(公告)日：2024-04-18

申请号：US18394561

申请日：2023-12-22

申请人： RevBio, Inc.

发明人： Brian J. Hess ,  George W. Kay

IPC分类号： A61L27/12 ,  A61C5/35 ,  A61C5/70 ,  A61C8/00 ,  A61C13/271 ,  A61F2/28 ,  A61F2/44 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61L24/00 ,  A61L24/02 ,  A61L27/02 ,  A61L27/36 ,  A61L27/58

CPC分类号： A61L27/12 ,  A61C5/35 ,  A61C5/70 ,  A61C8/0009 ,  A61C13/26 ,  A61F2/2803 ,  A61F2/4455 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61L24/0005 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/02 ,  A61L27/025 ,  A61L27/3604 ,  A61L27/3616 ,  A61L27/58 ,  A61F2002/2835 ,  A61F2002/30448 ,  A61L2430/12

摘要： The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

公开(公告)号：US20240065945A1

公开(公告)日：2024-02-29

申请号：US18269981

申请日：2021-12-28

申请人： Kuraray Noritake Dental Inc.

发明人： Ryo FUJIMAKI

IPC分类号： A61K6/864 ,  A61Q11/00

CPC分类号： A61K6/864 ,  A61Q11/00

摘要： The present invention provides curable calcium phosphate dental cement that has excellent sealability for dentinal tubule, is expected to form fluoroapatite, and has a curing time that is advantageous for clinical use. The present invention is directed to curable calcium phosphate dental cement including: a first material as powder or nonaqueous paste; and a second material as liquid or aqueous paste, and, in the curable calcium phosphate dental cement, the first material comprises tetracalcium phosphate (A), alkali metal salt of phosphoric acid (B), and acidic calcium phosphate (C), the second material comprises water (D), and at least one of the first material and the second material comprises a fluorine compound (E) and an organic acid (F) having a molecular weight of 10000 or less.

公开(公告)号：US11638777B2

公开(公告)日：2023-05-02

申请号：US17122816

申请日：2020-12-15

申请人： RevBio, Inc.

发明人： Brian J. Hess ,  George W. Kay

IPC分类号： A61L27/12 ,  A61L27/02 ,  A61K6/30 ,  A61K6/60 ,  A61K6/75 ,  A61K6/838 ,  A61K6/864 ,  A61K6/876 ,  A61C5/70 ,  A61C5/35 ,  A61C8/00 ,  A61C13/271 ,  A61F2/28 ,  A61F2/44 ,  A61L24/00 ,  A61L24/02 ,  A61L27/36 ,  A61L27/58 ,  A61F2/30

摘要： The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.