公开(公告)号：US20220000722A1

公开(公告)日：2022-01-06

申请号：US17463002

申请日：2021-08-31

申请人： MESOSIL INC.

发明人： Cameron Alexander STEWART ,  Benjamin David HATTON ,  Yoav FINER

IPC分类号： A61K6/84 ,  C08L33/12 ,  A01N25/08 ,  A01N43/40 ,  A01N47/44 ,  A61K6/20 ,  A61K6/35 ,  A61K6/40 ,  A61K6/54 ,  A61K6/71 ,  A61K6/74 ,  A61K6/76 ,  A61K6/80 ,  A61K6/802 ,  A61K6/849 ,  A61K6/853 ,  A61K6/86 ,  A61K6/864 ,  A61K6/871 ,  A61K9/00 ,  A61K9/14 ,  A61K9/51 ,  A61K31/155 ,  A61K31/20 ,  A61K31/444 ,  A61K31/4425 ,  A61K31/785 ,  A61L27/02 ,  A61L27/10 ,  A61L27/12 ,  A61L27/30 ,  A61L27/32 ,  A61L27/42 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61P1/02 ,  A61P31/02 ,  A61P31/04 ,  C07C279/14 ,  C07C279/26 ,  C07D213/20 ,  C07D213/74 ,  C08K3/22 ,  C08K3/32

摘要： A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

公开(公告)号：US20220054364A1

公开(公告)日：2022-02-24

申请号：US17464211

申请日：2021-09-01

申请人： MESOSIL INC.

发明人： Cameron Alexander STEWART ,  Benjamin David HATTON ,  Yoav FINER

IPC分类号： A61K6/84 ,  A61L27/56 ,  C07C279/26 ,  C07D213/74 ,  C07C279/14 ,  A61K31/4425 ,  A61K31/155 ,  C07D213/20 ,  A61K31/444 ,  A61L27/54 ,  A61K9/00 ,  A61L27/42 ,  A61L27/30 ,  A61L27/44 ,  A61K9/14 ,  A61P1/02 ,  A01N25/08 ,  A61P31/04 ,  A61P31/02 ,  A61K9/51 ,  A61L27/32 ,  A61K31/785 ,  A61L27/12 ,  A61L27/10 ,  A61L27/02 ,  A01N43/40 ,  A01N47/44 ,  A61K31/20 ,  A61K6/20 ,  A61K6/35 ,  A61K6/40 ,  A61K6/54 ,  A61K6/71 ,  A61K6/74 ,  A61K6/76 ,  A61K6/80 ,  A61K6/86 ,  A61K6/802 ,  A61K6/849 ,  A61K6/853 ,  A61K6/864 ,  A61K6/871 ,  C08K3/22 ,  C08K3/32 ,  C08L33/12

摘要： A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.