公开(公告)号：US12173040B2

公开(公告)日：2024-12-24

申请号：US17443012

申请日：2021-07-19

Applicant: Ferring B.V. ,  Brookhaven Science Associates, LLC

Inventor： Paul O. Zamora ,  Brent Lee Atkinson ,  Xinhua Lin ,  Louis A. Pena

IPC: A61K38/18 ,  A61L27/12 ,  A61L27/16 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/50 ,  C07K14/47 ,  C07K14/51

Abstract: A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.

公开(公告)号：US12144909B2

公开(公告)日：2024-11-19

申请号：US17136584

申请日：2020-12-29

Applicant: Zavation Medical Products, LLC

Inventor： Jeffrey Johnson ,  Nels J Lauritzen ,  Brent Mitchell

IPC: A61L27/38 ,  A61F2/28 ,  A61L24/02 ,  A61L27/12 ,  A61L27/24 ,  A61L27/46 ,  A61L27/54

Abstract: A biocompatible material for bone repair is described. The bone repair composition includes a mixture of a type I collagen, a type I collagen-glycosaminoglycan coprecipitate, tricalcium phosphate; and bioactive glass. Methods of using the composition for bone repair, and a kit for the bone repair composition are also described.

公开(公告)号：US12115274B2

公开(公告)日：2024-10-15

申请号：US17692460

申请日：2022-03-11

Applicant: Popeye Marine Biotechnology Limited

Inventor： Yi-Jen Sheng ,  Yu-Hao Chan ,  Yu-Quan Peng

IPC: A61L27/12 ,  A61L27/56

CPC classification number: A61L27/12 ,  A61L27/56 ,  A61L2430/02

Abstract: The present invention provides a porous tricalcium phosphate material, modified from a coral bone and having a plurality of pores, wherein the average compressive strength of the porous tricalcium phosphate material is 4 kgf to 9 kgf. Besides, the present invention also provides a method for bone healing and a manufacturing method for the porous tricalcium phosphate material. The porous tricalcium phosphate material of the present invention has the advantages of biocompatibility and no immunological rejection response, and also has significantly better mechanical properties and bone healing efficacy so as to better meet the needs of the patients.

公开(公告)号：US12053215B2

公开(公告)日：2024-08-06

申请号：US18147167

申请日：2022-12-28

Applicant: Bone Solutions, Inc.

Inventor： Frankie Morris ,  Drew Diaz ,  Brandon Roller

IPC: A61B17/86 ,  A61F2/30 ,  A61F2/44 ,  A61L27/04 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC classification number: A61B17/866 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2/447 ,  A61L27/047 ,  A61L27/06 ,  A61L27/12 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61F2002/30827 ,  A61F2002/30985 ,  A61F2310/00023 ,  A61F2310/00041 ,  A61F2310/00359 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/24 ,  A61L2430/38

Abstract: The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.

公开(公告)号：US20240245827A1

公开(公告)日：2024-07-25

申请号：US18405569

申请日：2024-01-05

Applicant: Marine Biomedical Pty Ltd

Inventor： Rui Ruan ,  Ming-Hao Zheng

IPC: A61L27/12 ,  A61K33/06 ,  A61K33/42 ,  A61L27/36

CPC classification number: A61L27/12 ,  A61K33/06 ,  A61K33/42 ,  A61L27/3604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/12

Abstract: The invention relates to a calcified tissue substitute and methods of manufacturing and use related thereto. The methods for manufacturing a calcified tissue substitute include reacting ground nacre, monocalcium phosphate, and water to produce brushite; grinding the brushite; reacting ground nacre with the ground brushite disodium hydrogen phosphate solution. Methods for repairing and/or strengthening a calcified tissue in need thereof are provided, as well as a delivery device for delivering the calcified tissue substitute.

公开(公告)号：US20240148983A1

公开(公告)日：2024-05-09

申请号：US18407094

申请日：2024-01-08

Applicant: Arya Medical, Inc.

Inventor： John P. FEZZA ,  Felix VEGA ,  Darrin James KENT ,  David James PRINCE

IPC: A61M5/32 ,  A61L27/12 ,  A61L27/18 ,  A61L27/20

CPC classification number: A61M5/3271 ,  A61L27/12 ,  A61L27/18 ,  A61L27/20 ,  A61M5/3234 ,  A61M2005/3201

Abstract: A device for performing injections in a patient includes a syringe holder with a needle guard, a cannula extending from the syringe holder, a needle slidably disposed over the cannula, and a slider on the syringe holder. The cannula has a blunt tip and a cannula length, and the needle has a sharp tip and a needle length that is shorter than the cannula length. The slider is coupled with the needle and is configured to slide the needle along the cannula from an extended position, in which the sharp tip of the needle is located at or immediately adjacent the blunt tip of the cannula, to a retracted position, in which the sharp tip is housed within the needle guard of the syringe holder.

公开(公告)号：US20240058508A1

公开(公告)日：2024-02-22

申请号：US18270640

申请日：2022-07-27

Applicant: KOREA INSTITUTE OF MATERIALS SCIENCE

Inventor： Hong-hyun PARK ,  Hui-suk YUN ,  Yeong-jin CHOI

IPC: A61L27/52 ,  A61L27/12 ,  A61L27/20

CPC classification number: A61L27/52 ,  A61L27/12 ,  A61L27/20

Abstract: The present invention relates to a composition for preparing an organic-inorganic complex hydrogel and a kit for preparing an organic-inorganic complex hydrogel comprising same, and specifically, to a composition for preparing an organic-inorganic complex hydrogel and a kit for preparing an organic-inorganic complex hydrogel comprising same, comprising: a biocompatible polymer having a photocrosslinkable functional group; and a calcium phosphate-based ceramic powder.

公开(公告)号：US11904070B2

公开(公告)日：2024-02-20

申请号：US16485882

申请日：2018-02-12

Applicant: Locate Therapeutics Limited

Inventor： Antonio Leonardi ,  Helen Celia Cox ,  Robin Andrew Quirk ,  Kevin Morris Shakesheff

IPC: A61L27/26 ,  A61L27/18 ,  A61L27/10 ,  A61L27/12 ,  A61L27/38 ,  A61K38/18 ,  A61L27/50 ,  A61L27/54

CPC classification number: A61L27/26 ,  A61K38/1875 ,  A61L27/10 ,  A61L27/12 ,  A61L27/18 ,  A61L27/38 ,  A61L27/502 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/62 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/38

Abstract: The invention relates to a scaffold material composition for forming a solid tissue scaffold, the composition comprising a plurality of hollow polymer pellets, each pellet comprising an open hollow extending through the pellet, and wherein the plurality of hollow polymer pellets are capable of interlinking and setting into a solid scaffold. The invention further relates to associated compositions, uses, method of treatment and kits associated with such material.

公开(公告)号：US11891438B2

公开(公告)日：2024-02-06

申请号：US18339147

申请日：2023-06-21

Applicant: OSSIFI-MAB LLC

Inventor： Debra L. Ellies

IPC: A61K38/18 ,  A61K38/17 ,  C07K16/22 ,  A61K31/59 ,  A61K39/395 ,  A61K45/06 ,  A61L27/12 ,  A61L27/54 ,  A61K31/66 ,  A61K31/7088 ,  A61K31/713 ,  A61P19/08

CPC classification number: C07K16/22 ,  A61K31/59 ,  A61K31/66 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/1709 ,  A61K38/1875 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/256 ,  A61L2300/432 ,  A61L2430/02 ,  A61P19/08 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/76 ,  A61K31/59 ,  A61K2300/00 ,  A61K38/1875 ,  A61K2300/00 ,  A61K39/395 ,  A61K2300/00

Abstract: The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and Periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug.

公开(公告)号：US11883562B2

公开(公告)日：2024-01-30

申请号：US16955522

申请日：2018-12-18

Applicant: UNIVERSIDADE DE AVEIRO

Inventor： João Filipe Colardelle Da Luz Mano ,  Catarina De Almeida Custódio ,  Sara Catarina Nunes Da Silva Santos

IPC: A61L27/52 ,  A61L27/10 ,  A61L27/12 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/56 ,  C12M1/12

CPC classification number: A61L27/52 ,  A61L27/10 ,  A61L27/12 ,  A61L27/26 ,  A61L27/3616 ,  A61L27/3834 ,  A61L27/56 ,  C12M25/00 ,  A61L2300/414 ,  A61L2400/06

Abstract: The present disclosure relates to bioactive hydrogels derived from human blood plasma. More particularly, the disclosure relates to multifunctional materials for cell encapsulation, cell culture platforms, medical treatment apparatus and methods, more particularly, hydrogels derived from human blood components and technologies for use of such materials in research, biomedical treatment, biotech and pharmaceutical industry. The disclosure further relates to 3D printable scaffolds, sponges, foams, fibers, particles, capsules, membranes and injectable systems comprising said hydrogel. Additionally, this disclosure allows for the controlled placement of biologically active components that may be delivered by the hydrogel compositions.