公开(公告)号：US12220467B2

公开(公告)日：2025-02-11

申请号：US17463002

申请日：2021-08-31

Applicant: MESOSIL INC.

Inventor： Cameron Alexander Stewart ,  Benjamin David Hatton ,  Yoav Finer

IPC: A61K6/84 ,  A01N25/08 ,  A01N43/40 ,  A01N47/44 ,  A61K6/20 ,  A61K6/35 ,  A61K6/40 ,  A61K6/54 ,  A61K6/71 ,  A61K6/74 ,  A61K6/76 ,  A61K6/80 ,  A61K6/802 ,  A61K6/849 ,  A61K6/853 ,  A61K6/86 ,  A61K6/864 ,  A61K6/871 ,  A61K9/00 ,  A61K9/14 ,  A61K9/51 ,  A61K31/155 ,  A61K31/20 ,  A61K31/4425 ,  A61K31/444 ,  A61K31/785 ,  A61L27/02 ,  A61L27/10 ,  A61L27/12 ,  A61L27/30 ,  A61L27/32 ,  A61L27/42 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61P1/02 ,  A61P31/02 ,  A61P31/04 ,  C07C279/14 ,  C07C279/26 ,  C07D213/20 ,  C07D213/74 ,  C08K3/22 ,  C08K3/32 ,  C08L33/10 ,  C08L33/12 ,  C08L75/04

Abstract: A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

公开(公告)号：US20240390150A1

公开(公告)日：2024-11-28

申请号：US18790605

申请日：2024-07-31

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Thomas J. WEBSTER ,  Venu PERLA

IPC: A61F2/30 ,  A61B17/08 ,  A61K9/00 ,  A61L27/04 ,  A61L27/32 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L31/02 ,  A61L31/16 ,  C25D5/34 ,  C25D11/02

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

公开(公告)号：US12128158B2

公开(公告)日：2024-10-29

申请号：US18108038

申请日：2023-02-10

Applicant: DSM IP Assets B.V.

Inventor： Noel L. Davison ,  Henricus Johannes Arts ,  Aylvin Jorge Angelo Athanasius Dias ,  Anne Marie Persson ,  Ruud Jozef Regina Wilhelmus Peters

IPC: A61L31/08 ,  A61L17/04 ,  A61L17/14 ,  A61L27/18 ,  A61L27/32 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08L75/04

CPC classification number: A61L31/086 ,  A61L17/04 ,  A61L17/145 ,  A61L27/18 ,  A61L27/32 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  C08L75/04 ,  A61L2420/02 ,  A61L2430/02 ,  A61L2430/38

Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

公开(公告)号：US12083247B2

公开(公告)日：2024-09-10

申请号：US17485766

申请日：2021-09-27

Applicant: Prosidyan, Inc.

Inventor： Charanpreet S. Bagga ,  Steve B. Jung ,  Hyun W. Bae

IPC: A61L27/56 ,  A61L27/10 ,  A61L27/12 ,  A61L27/30 ,  A61L27/32 ,  A61L27/42 ,  A61L27/44 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L71/02

CPC classification number: A61L27/56 ,  A61L27/10 ,  A61L27/12 ,  A61L27/306 ,  A61L27/32 ,  A61L27/425 ,  A61L27/427 ,  A61L27/446 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L71/02 ,  A61L2430/02

Abstract: Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may take the form of a putty, foam, fibrous cluster, fibrous matrix, granular matrix, or combinations thereof and allow for enhanced clinical results as well as ease of handling.

公开(公告)号：US20240207482A1

公开(公告)日：2024-06-27

申请号：US18543587

申请日：2023-12-18

Applicant: Rohit Khanna

Inventor： Rohit Khanna

IPC: A61L27/32 ,  A61L27/06 ,  A61L27/54 ,  A61L27/56 ,  B33Y70/00 ,  B33Y80/00 ,  C25D11/02 ,  C25D11/26

CPC classification number: A61L27/32 ,  A61L27/06 ,  A61L27/54 ,  A61L27/56 ,  B33Y70/00 ,  B33Y80/00 ,  C25D11/024 ,  C25D11/026 ,  C25D11/26 ,  A61L2300/412 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/02 ,  C23C24/087

Abstract: A method of producing a bioactive surface on a medical device configured for cementless implantation is disclosed. The method can include treating a titanium metal or titanium alloy medical device, optionally having a titanium metal or titanium alloy porous coating, with a series of steps to obtain the bioactive surface having a nanofibrous network of titanate overlaid with hydroxyapatite particles or film. The steps can include treating the medical device with an acidic solution to obtain an activated surface; oxidizing the activated surface using plasma electrolytic oxidation to obtain an oxide layer having bioactive elements, compounds, or phases; treating the oxide layer with an alkaline solution to obtain the bioactive surface; and treating the bioactive surface with an iodine containing compound to obtain an antibacterial and bioactive surface.

公开(公告)号：US11998659B2

公开(公告)日：2024-06-04

申请号：US17673651

申请日：2022-02-16

Applicant: KYOCERA CORPORATION ,  Takao Hotokebuchi

Inventor： Takao Hotokebuchi ,  Iwao Noda

IPC: A61L27/32 ,  A61L27/06 ,  A61L27/30 ,  A61L27/42 ,  A61L27/54

CPC classification number: A61L27/32 ,  A61L27/06 ,  A61L27/306 ,  A61L27/425 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/24

Abstract: To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria.

公开(公告)号：US11992578B2

公开(公告)日：2024-05-28

申请号：US17319145

申请日：2021-05-13

Applicant: Orbray Co., Ltd. ,  Tokyo Metropolitan Public University Corporation

Inventor： Hikaru Muto ,  Satoshi Kobayashi

IPC: A61L27/32 ,  A61L27/10 ,  C04B35/488 ,  C04B41/85

CPC classification number: A61L27/32 ,  A61L27/10 ,  C04B35/488 ,  C04B41/85 ,  A61L2430/02

Abstract: A zirconia material manufacturing method includes: dispersing hydroxyapatite powder in water to prepare a slurry having a hydroxyapatite powder concentration of 1%; and dipping zirconia in the slurry to form, on the zirconia, a coating layer containing hydroxyapatite.

公开(公告)号：US20240024535A1

公开(公告)日：2024-01-25

申请号：US18372863

申请日：2023-09-26

Applicant: DEPUY SYNTHES PRODUCTS, INC.

Inventor： Rajendra Kasinath ,  Craig Ernsberger ,  Stephanie Vass ,  Steven N. Ginn ,  Haibo Qu ,  Weidong Tong

IPC: A61L27/32 ,  A61L27/06 ,  A61L27/56 ,  A61L27/58 ,  A61L27/04 ,  A61L27/50 ,  A61L27/54

CPC classification number: A61L27/32 ,  A61L27/06 ,  A61L27/56 ,  A61L27/58 ,  A61L27/045 ,  A61L27/50 ,  A61L27/54 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/18

Abstract: An orthopedic implant having a metal surface and a calcium phosphate layer disposed on at least part of the metal surface is described. The calcium phosphate layer has an average crystallite size of less than about 100 nm in at least one direction and dissolves for more than 2 hours in vitro. The calcium phosphate layer is substantially free of carbonate. The coating, which is formed on a sodium titanate surface, has increased shear strength and tensile strength. The coating is formed by a solution deposited hydroxyapatite process under inert conditions. The pH of the solution varies by less than 0.1 pH unit/hour during coating formation.

公开(公告)号：US20230347019A1

公开(公告)日：2023-11-02

申请号：US17796529

申请日：2021-01-29

Applicant: Wright Medical Technology, Inc.

Inventor： Barbara E. Blum ,  Jon P. Moseley

IPC: A61L27/42 ,  A61L27/32

CPC classification number: A61L27/427 ,  A61L27/32 ,  A61L2430/02 ,  A61L2400/06 ,  A61L2300/802

Abstract: The present disclosure relates to bone graft substitute formulations with a liquid weight to powder weight ratio (L/P) of about 0.35 to about 0.40. The formulations disclosed herein have significantly longer set times than formulations with lower L/P ratios, and yet the cement resulting from the formulations disclosed herein have comparable dissolution rates to those of formulations having a lower L/P. The present disclosure also relates to kits for making the bone graft substitute formulations and methods of treating bone defects with said formulations.

公开(公告)号：US20230147429A1

公开(公告)日：2023-05-11

申请号：US17915432

申请日：2020-03-30

Applicant: SAGA UNIVERSITY ,  KYOCERA CORPORATION

Inventor： Masaaki MAWATARI ,  Iwao NODA

IPC: A61F2/36 ,  A61L27/32 ,  A61F2/30 ,  B05D3/12 ,  B05D5/02

CPC classification number: A61F2/3662 ,  A61F2/3094 ,  A61L27/32 ,  B05D3/12 ,  B05D5/02 ,  A61F2002/30321 ,  A61F2002/30324 ,  A61F2002/30326

Abstract: In the present disclosure, an artificial joint stem includes a base and a coating film located on the base. The base includes a first region, a second region, and a third region located in sequence. The coating film contains a calcium phosphate-based material and an antimicrobial material. The coating film is located across the first region and the second region, and the third region is exposed from the coating film. The surface of the coating film located in the first region has a larger surface roughness than the surface of the base in the third region.