公开(公告)号：US20240050629A1

公开(公告)日：2024-02-15

申请号：US18481827

申请日：2023-10-05

申请人： Nanovis, LLC

发明人： Matthew HEDRICK ,  Chang YAO

IPC分类号： A61L27/54 ,  C23C22/05 ,  C25D11/02 ,  C23C22/78 ,  A61L27/04 ,  A61L27/30 ,  C25D11/26 ,  C25D11/34 ,  C09D1/00 ,  C09D7/61 ,  C04B35/447 ,  C04B35/622 ,  C09D5/14

CPC分类号： A61L27/54 ,  C23C22/05 ,  C25D11/02 ,  C23C22/78 ,  A61L27/04 ,  A61L27/306 ,  C25D11/26 ,  C25D11/34 ,  C09D1/00 ,  C09D7/61 ,  C04B35/447 ,  C04B35/62222 ,  C09D5/14 ,  A61L2202/21 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2300/102 ,  A61L2300/61 ,  A61L2420/02 ,  C04B2235/447

摘要： An antimicrobial medical device that includes a substrate having a metal surface that is made from a metal or metal alloy that may include stainless steel, cobalt, and titanium. Disposed on the metal surface is a first antimicrobial oxide layer that includes an antimicrobial metal that may include silver, copper, and zinc, and combinations thereof. The atoms of antimicrobial metal in the first antimicrobial oxide layer are of a first concentration. The first antimicrobial oxide layer is positioned in a direction opposite that of the metal surface. The device further includes a second antimicrobial oxide layer that includes an antimicrobial metal that may be silver, copper, and zinc, and combinations thereof. The atoms of the antimicrobial metal present in the second antimicrobial oxide layer are of a second concentration. The first concentration and the second concentration are not equal. Methods for making the antimicrobial medical device are also disclosed.

公开(公告)号：US20240050624A1

公开(公告)日：2024-02-15

申请号：US18034561

申请日：2021-11-04

申请人： Maruemu Works Co., LTD.

发明人： Shigeru YAMANAKA ,  Kengo NARITA

IPC分类号： A61L27/50 ,  A61L27/06 ,  A61L27/30

CPC分类号： A61L27/50 ,  A61L27/06 ,  A61L27/306 ,  A61L2420/06 ,  A61L2430/02 ,  A61L2430/12

摘要： The present invention provides a biocompatible material that has a membrane capable of achieving osteogenesis therearound in a relatively short period of time. The biocompatible material provided by the present invention has a membrane that co rises magnesium optionally together with calcium, wherein: when the total weight of magnesium and calcium in the membrane is regarded as 100 wt %, the calcium content of the membrane is 0-40 wt %; and the arithmetic mean surface height Sa1 of the surface roughness of the membrane is 2 μm or less and/or the arithmetic mean surface height Ra1 of the line roughness of the membrane is 2 μm or Less.

公开(公告)号：US20230380982A1

公开(公告)日：2023-11-30

申请号：US18229883

申请日：2023-08-03

申请人： Tyber Medical LLC

发明人： Jeffrey Tyber ,  Rui Ferreira ,  Christopher Faresich ,  Donald Buss

IPC分类号： A61F2/42 ,  A61B17/16 ,  A61B17/72 ,  A61B17/80 ,  A61B17/88 ,  A61B90/94 ,  A61F2/28 ,  A61F2/44 ,  A61F2/46 ,  A61L27/02 ,  A61L27/04 ,  A61L27/30 ,  A61B17/70

CPC分类号： A61F2/4225 ,  A61B17/1682 ,  A61B17/7291 ,  A61B17/8095 ,  A61B17/8852 ,  A61B90/94 ,  A61F2/28 ,  A61F2/44 ,  A61F2/447 ,  A61F2/4455 ,  A61F2/4465 ,  A61F2/4603 ,  A61F2/4606 ,  A61F2/4611 ,  A61L27/025 ,  A61L27/04 ,  A61L27/306 ,  A61B17/1615 ,  A61B17/70 ,  A61L2400/18 ,  A61B17/7059 ,  A61F2/30771

摘要： A method of joining adjacent bone includes providing a medical device having a first implant portion, a second implant portion attached to the first implant portion, and a driver assembly having an instrument adapted to form an opening in bone. The driver assembly is integrally connected to and removably attached to the second implant portion at a connection, distal from the first implant portion. The driver assembly further has a wire driver extending therefrom, distal from the first implant portion. The method further includes inserting the wire driver into a wire driver tool; placing the first implant portion against a first bone structure; inserting the first implant portion into the first bone structure; removing the second implant portion from the driver assembly; using the driver assembly to form an opening in a second bone structure, adjacent to the first bone structure; and inserting the second implant portion into the opening.

公开(公告)号：US20230330303A1

公开(公告)日：2023-10-19

申请号：US18213345

申请日：2023-06-23

申请人： Smith & Nephew, Inc.

发明人： Vivek Pawar ,  Donald E. Kramer ,  Carolyn L. Weaver ,  Shilesh C. Jani

IPC分类号： A61L27/50 ,  A61L27/04 ,  A61L27/30

CPC分类号： A61L27/50 ,  A61L27/04 ,  A61L27/306 ,  A61L2400/18

摘要： A medical implant is disclosed. The medical implant includes: a first biocompatible metal forming a substrate (210, 310, 410), a second biocompatible metal diffused into the first biocompatible metal to form an biocompatible alloy surface (220, 314, 414), the alloy surface further including a diffusion hardening species, wherein the diffusion hardening species may be carbon, nitrogen, oxygen, boron, or any combination thereof. A method of forming a medical implant is also disclosed. The method includes the steps of: providing a first biocompatible metal or alloy that forms a substrate (210, 310, 410), providing a second biocompatible metal or alloy, diffusing the second biocompatible metal into the first biocompatible metal to form an alloy layer (220, 314, 414), removing excess second metal material from the substrate to expose the alloy layer, and diffusion hardening the alloy layer.

公开(公告)号：US20230302205A1

公开(公告)日：2023-09-28

申请号：US18324941

申请日：2023-05-26

申请人： Duke University

发明人： Benjamin J. WILEY ,  Huayu TONG ,  Jiacheng ZHAO

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L24/02 ,  A61L27/34 ,  A61L27/32 ,  A61L27/36 ,  A61L27/30

CPC分类号： A61L27/52 ,  A61L27/20 ,  A61L24/02 ,  A61L27/34 ,  A61L27/32 ,  A61L27/3608 ,  A61L27/306 ,  A61L2400/12 ,  A61L2430/06 ,  A61L2430/02

摘要： Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.

公开(公告)号：US20230293765A1

公开(公告)日：2023-09-21

申请号：US18324847

申请日：2023-05-26

申请人： HEBEI UNIVERSITY OF TECHNOLOGY

发明人： Chunyong LIANG ,  Xianrui ZOU ,  Hongshui WANG ,  Tai YANG ,  Huan ZHOU

IPC分类号： A61L27/32 ,  A61L27/30

CPC分类号： A61L27/32 ,  A61L27/306 ,  A61L2300/404 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2430/02

摘要： Provided are a medical material for promoting cell growth and inhibiting bacterial adhesion and a machining method thereof. The machining method comprises: modifying a surface component of the medical material; preparing a micro-nano structure formed by superposing multiple levels of sizes; and selecting one of the two steps above, or carrying out component modification on a surface of the medical material first and then forming the micro-nano structure by superposing the multiple levels of sizes. The micro-nano structure formed by superposing the multiple levels of sizes comprises a first-level structure which is a micron-level groove structure, a second-level structure which is a submicron-level stripe structure or an array protrusion structure and a third-level structure which is a nano-level protrusion structure, the second-level structure is distributed on a surface of the first-level structure, and the third-level structure is distributed on a surface of the second-level structure.

公开(公告)号：US11707555B2

公开(公告)日：2023-07-25

申请号：US17365076

申请日：2021-07-01

申请人： Duke University

发明人： Benjamin J. Wiley ,  Huayu Tong ,  Jiacheng Zhao

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L24/02 ,  A61L27/34 ,  A61L27/32 ,  A61L27/36 ,  A61L27/30

CPC分类号： A61L27/52 ,  A61L24/02 ,  A61L27/20 ,  A61L27/306 ,  A61L27/32 ,  A61L27/34 ,  A61L27/3608 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06

摘要： Described herein are hydrogels attached to a base with the strength and fatigue comparable to that of cartilage on bone and methods of forming them. The methods and apparatuses described herein may achieve an attachment strength between a hydrogel and a substrate equivalent to the osteochondral junction. In some examples the hydrogel may be a triple-network hydrogel (such as BC-PVA-PAMPS) that is attached to a porous substrate (e.g., a titanium base) with the shear strength and fatigue strength equivalent to that of the osteochondral junction.

公开(公告)号：US20230226254A1

公开(公告)日：2023-07-20

申请号：US17983338

申请日：2022-11-08

申请人： City University of Hong Kong

发明人： Guomin WANG ,  Paul Kim Ho CHU ,  Kaiwei TANG ,  Zheyi MENG

IPC分类号： A61L27/30 ,  A61L31/16

CPC分类号： A61L27/306 ,  A61L31/16

摘要： An antibacterial implantable medical device or medical material. The surface of an implantable medical device or medical material has a titanium coating formed thereon. Titanium nitride nanowires are formed that extend from the titanium coating at a selected angle to exert a mechanical force on bacteria bilayer membranes sufficient to at least partially disrupt the bacteria bilayer membranes. In one aspect, the titanium nitride nanowires are formed from grown titanium dioxide nanowires by converting the titanium dioxide nanowires to titanium nitride in a heated nitrogen-containing environment. The titanium nitride nanowires are optionally charged to further enhance antibacterial properties.

公开(公告)号：US20190231911A1

公开(公告)日：2019-08-01

申请号：US16338005

申请日：2017-09-29

申请人： Eastern Technologies, Inc.

发明人： Mark Steven Moroney

IPC分类号： A61L2/00 ,  A61L2/18 ,  A61L2/22

CPC分类号： A61L2/0088 ,  A61L2/00 ,  A61L2/18 ,  A61L2/22 ,  A61L15/18 ,  A61L15/44 ,  A61L15/46 ,  A61L17/005 ,  A61L26/0004 ,  A61L27/306 ,  A61L29/106 ,  A61L31/088 ,  A61L2300/106 ,  A61L2300/406 ,  A61L2420/02

摘要： Compositions that are suitable for use as a disinfectant are disclosed. Methods of making and using compositions that are suitable for use as a disinfectant are also disclosed.

公开(公告)号：US20190194782A1

公开(公告)日：2019-06-27

申请号：US16277173

申请日：2019-02-15

申请人： University of Florida Research Foundation, Inc.

发明人： Michele Manuel ,  Josephine Allen ,  Jordan P. Ball ,  Harpreet Singh Brar ,  Ida Svensson BERGLUND

IPC分类号： C22C23/00 ,  C22F1/06 ,  A61L27/58 ,  C22C1/04 ,  C22C23/06 ,  A61L27/30 ,  A61L27/04

CPC分类号： C22C23/00 ,  A61L27/047 ,  A61L27/306 ,  A61L27/58 ,  A61L2400/18 ,  A61L2420/02 ,  C22C1/0408 ,  C22C23/06 ,  C22F1/06

摘要： Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.