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公开(公告)号：US12016977B2
公开(公告)日：2024-06-25
申请号：US16753355
申请日：2018-10-05
申请人： DSM IP Assets B.V.
发明人： Noel L. Davison , Henricus Johannes Arts , Aylvin Jorge Angelo Athanasius Dias , Anne Marie Persson , Ruud Jozef Regina Wilhelmus Peters
IPC分类号： A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC分类号： A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
摘要： The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
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公开(公告)号：US12128158B2
公开(公告)日：2024-10-29
申请号：US18108038
申请日：2023-02-10
申请人： DSM IP Assets B.V.
发明人： Noel L. Davison , Henricus Johannes Arts , Aylvin Jorge Angelo Athanasius Dias , Anne Marie Persson , Ruud Jozef Regina Wilhelmus Peters
IPC分类号： A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC分类号： A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
摘要： The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
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3.发明授权公开(公告)号：US12076463B2
公开(公告)日：2024-09-03
申请号：US17849893
申请日：2022-06-27
CPC分类号： A61L27/46 , A61L27/446 , A61L27/54 , A61L27/56 , A61L2420/02 , A61L2420/04 , A61L2430/02 , C08L75/04
摘要： The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.
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