公开(公告)号：US20220203556A1

公开(公告)日：2022-06-30

申请号：US17605571

申请日：2020-04-22

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Benjamin David Hatton ,  Kurtis Allan Laqua

IPC分类号： B25J15/00 ,  A61B34/00 ,  B25J15/08 ,  A61B90/00

摘要： A system for controllably establishing adhesion or friction with an external body. The system comprises a channel member and an interface member. The channel member comprises fluidic channels communicating positive or negative pressure. The interface member is disposed over the channel member. The interface member comprises exposed portions and topographic members. The exposed portions are flexible and exposed to the pressure communicated by the fluidic channels. The exposed portions deform under the pressure communicated by the fluidic channels and reform in the absence of the pressure communicated by the fluidic channels. The exposed portions assume a convex shaped under positive pressure and concave shaped configuration under negative pressure. The topographic members are provided over the exposed portions. The topographic members move based on the deformation of the exposed portions. The strength of adhesion varies based on the deformation of the exposed portions.

公开(公告)号：US11129774B2

公开(公告)日：2021-09-28

申请号：US16301773

申请日：2017-05-16

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Cameron Alexander Stewart ,  Benjamin David Hatton ,  Yoav Finer

IPC分类号： A61K8/14 ,  A61K6/84 ,  A61L27/56 ,  C07C279/26 ,  C07D213/74 ,  C07C279/14 ,  A61K31/4425 ,  A61K31/155 ,  C07D213/20 ,  A61K31/444 ,  A61L27/54 ,  A61K9/00 ,  A61L27/42 ,  A61L27/30 ,  A61L27/44 ,  A61K9/14 ,  A61P1/02 ,  A01N25/08 ,  A61P31/04 ,  A61P31/02 ,  A61K9/51 ,  A61L27/32 ,  A61K31/785 ,  A61L27/12 ,  A61L27/10 ,  A61L27/02 ,  A01N43/40 ,  A01N47/44 ,  A61K31/20 ,  A61K6/20 ,  A61K6/35 ,  A61K6/40 ,  A61K6/54 ,  A61K6/71 ,  A61K6/74 ,  A61K6/76 ,  A61K6/80 ,  A61K6/86 ,  A61K6/802 ,  A61K6/849 ,  A61K6/853 ,  A61K6/864 ,  A61K6/871 ,  C08K3/22 ,  C08K3/32 ,  C08L33/12

摘要： A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.