公开(公告)号：US12056607B2

公开(公告)日：2024-08-06

申请号：US16746692

申请日：2020-01-17

Applicant: Atomwise Inc.

Inventor： Abraham Samuel Heifets ,  Izhar Wallach ,  Kong Thong Nguyen

IPC: G06N3/08 ,  G06F18/00 ,  G06F18/214 ,  G06F18/2413 ,  G06N3/04 ,  G06N3/045 ,  G06N5/04 ,  G06V10/774 ,  G16B40/00 ,  G16C20/30 ,  G16C20/70 ,  G06N3/126 ,  G06N5/01 ,  G06N7/01 ,  G06N20/10 ,  G16B35/20 ,  G16C20/64

CPC classification number: G06N3/08 ,  G06F18/00 ,  G06F18/214 ,  G06F18/2413 ,  G06N3/04 ,  G06N3/045 ,  G06N5/04 ,  G06V10/774 ,  G16B40/00 ,  G16C20/30 ,  G16C20/70 ,  G06N3/126 ,  G06N5/01 ,  G06N7/01 ,  G06N20/10 ,  G16B35/20 ,  G16C20/64

Abstract: Systems and methods for classifying a test object are provided. For each respective target object in a plurality of target objects, a first procedure is performed comprising (a) posing the test object against the respective target thereby obtaining an interaction between the test and target, and (b) scoring the interaction with a first classifier. Each such score across the plurality of targets forms a test vector that is inputted into a second classifier thereby obtaining an indication of a target object. The second classifier is trained on training vectors, each being the output from instances of the first classifier after inputting a corresponding training object in a plurality of training objects in accordance with the first procedure. Each object in one subset of the training objects is uniquely associated with one of the targets. Another subset of the training objects is not associated with the targets.

公开(公告)号：US12018403B2

公开(公告)日：2024-06-25

申请号：US17087350

申请日：2020-11-02

Applicant: Adimab, LLC

Inventor： Maximiliano Vasquez ,  Arvind Sivasubramanian ,  Michael Feldhaus

IPC: C40B40/08 ,  C07K16/00 ,  C12N15/10 ,  G01N33/543 ,  G16B35/20 ,  C40B50/06 ,  G16B35/00 ,  G16C20/60

CPC classification number: C40B40/08 ,  C07K16/00 ,  C12N15/1089 ,  G01N33/543 ,  G16B35/20 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C40B50/06 ,  G16B35/00 ,  G16C20/60

Abstract: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.

公开(公告)号：US11965215B2

公开(公告)日：2024-04-23

申请号：US18167804

申请日：2023-02-10

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： David M. Kurtz ,  Maximilian Diehn ,  Arash Ash Alizadeh

IPC: G16B30/10 ,  C12N15/10 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B35/20 ,  G16B40/00 ,  G16H10/40 ,  G16H20/10 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  G16H70/60 ,  G16H10/60

CPC classification number: C12Q1/6886 ,  C12N15/1089 ,  C12Q1/6869 ,  C12Q1/6874 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10 ,  G16B35/20 ,  G16B40/00 ,  G16H10/40 ,  G16H20/10 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  G16H70/60 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/7028 ,  G16H10/60

Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

公开(公告)号：US20240096443A1

公开(公告)日：2024-03-21

申请号：US18037940

申请日：2021-11-30

Applicant: iBio, Inc.

Inventor： Alexander T. Taguchi ,  Kevin Eduard Hauser ,  Cody Allen Moore ,  Matthew P. Greving

IPC: G16B15/20 ,  G16B35/20 ,  G16B40/00 ,  G16B45/00

CPC classification number: G16B15/20 ,  G16B35/20 ,  G16B40/00 ,  G16B45/00

Abstract: Provided herein are methods for design of engineered polypeptides that recapitulate molecular structure features of a predetermined portion of several reference protein structures, e.g., related antibody epitopes or protein binding sites. A Machine Learning (ML) model may be used to generate engineered polypeptides. After substituting target residues for corresponding residues in other reference structures in the same scaffold, the scaffolds with each set of target residues may be filtered by structural comparison to identify generalized scaffolds. Generalized scaffolds may be improved by screening libraries of polypeptides.

公开(公告)号：US20240043912A1

公开(公告)日：2024-02-08

申请号：US18224725

申请日：2023-07-21

Applicant: Institute of Animal Sciences of CAAS

Inventor： Yan CHEN ,  Junya LI ,  Han GAO ,  Fei GE ,  Huijiang GAO ,  Xue GAO ,  Lupei ZHANG ,  Lingyang XU ,  Bo ZHU ,  Zezhao WANG

IPC: C12Q1/6827 ,  G16B20/40 ,  G16B20/20 ,  G16B35/20 ,  A01K67/02

CPC classification number: C12Q1/6827 ,  G16B20/40 ,  G16B20/20 ,  G16B35/20 ,  A01K67/02

Abstract: The present disclosure provides a genomic selection (GS) breeding chip of Huaxi cattle and use thereof, and relates to the technical field of molecular breeding. The present disclosure provides a molecular marker combination for whole-genome genotyping of Huaxi cattle, where a genotyping object involves 112,177 single nucleotide polymorphisms (SNPs) and 3 Indels, including seven marker panels in total. In the present disclosure, a genome-wide breeding chip constructed with the molecular marker combination has functional relevance, pertinence and effectiveness, innovation, comprehensiveness, practicality, and cost-effectiveness. This breeding chip also shows uniform distribution of chromosomes in the whole-genome, high coverage, and moderate throughput of markers. This breeding chip has desirable compatibility with existing commercial chips and high cost performance.

公开(公告)号：US20240035095A1

公开(公告)日：2024-02-01

申请号：US18481092

申请日：2023-10-04

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： David M. Kurtz ,  Maximilian Diehn ,  Arash Ash Alizadeh

IPC: C12Q1/6886 ,  G16B30/10 ,  G16B20/20 ,  G16B35/20 ,  G16B30/00 ,  C12Q1/6874 ,  G16H70/60 ,  G16H10/40 ,  G16H50/30 ,  G16H50/70 ,  G16H20/10 ,  G16B40/00 ,  G16B20/10 ,  C12N15/10 ,  G16H50/20 ,  C12Q1/6869 ,  G16B20/00

CPC classification number: C12Q1/6886 ,  G16B30/10 ,  G16B20/20 ,  G16B35/20 ,  G16B30/00 ,  C12Q1/6874 ,  G16H70/60 ,  G16H10/40 ,  G16H50/30 ,  G16H50/70 ,  G16H20/10 ,  G16B40/00 ,  G16B20/10 ,  C12N15/1089 ,  G16H50/20 ,  C12Q1/6869 ,  G16B20/00 ,  G16H10/60

Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

公开(公告)号：US20230414704A1

公开(公告)日：2023-12-28

申请号：US18144630

申请日：2023-05-08

Applicant: Vascular BioSciences ,  Sanford Burnham Prebys Medical Discovery Institute

Inventor： David Mann ,  Erkki Ruoslahti ,  Masanobu Komatsu

IPC: A61K38/12 ,  A61K47/68 ,  A61K31/18 ,  A61P13/12 ,  A61K31/506 ,  A61K38/55 ,  A61K31/222 ,  A61K31/573 ,  A61K47/64 ,  A61P1/16 ,  G01N33/15 ,  A61P11/00 ,  A61P9/12 ,  A61K31/436 ,  G16B35/00 ,  G16C20/60 ,  A61K31/438 ,  A61K38/08 ,  A61P35/00 ,  A61K45/06 ,  G01N33/50 ,  A61P31/00 ,  A61K31/337 ,  G16B35/10 ,  G16B35/20

CPC classification number: A61K38/12 ,  A61K47/6811 ,  A61K31/18 ,  A61P13/12 ,  A61K31/506 ,  A61K38/55 ,  A61K31/222 ,  A61K31/573 ,  A61K47/64 ,  A61P1/16 ,  A61K47/643 ,  G01N33/15 ,  A61P11/00 ,  A61P9/12 ,  A61K31/436 ,  G16B35/00 ,  G16C20/60 ,  A61K31/438 ,  A61K38/08 ,  A61P35/00 ,  A61K45/06 ,  G01N33/5008 ,  A61P31/00 ,  A61K31/337 ,  A61K47/6851 ,  G16B35/10 ,  G16B35/20

Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.

公开(公告)号：US20230326557A1

公开(公告)日：2023-10-12

申请号：US18170396

申请日：2023-02-16

Applicant: IOGENETICS, LLC

Inventor： Robert D. Bremel ,  Jane Homan

IPC: G16B30/10 ,  G16B20/30 ,  G16B35/20

CPC classification number: G16B30/10 ,  G16B35/20 ,  G16B20/30

Abstract: This invention pertains to the identification of antibody mediated epitope mimics and applications of the identification of said mimic peptides in the design of biotherapeutics and vaccines.

公开(公告)号：US20230274795A1

公开(公告)日：2023-08-31

申请号：US18060004

申请日：2022-11-30

Applicant: XENOTHERAPEUTICS, INC. ,  ALEXIS BIO, INC.

Inventor： Paul HOLZER ,  Rodney MONROY ,  Andrey PTITSYN ,  Elizabeth CHANG ,  Jon ADKINS ,  Travis BROWN ,  Kaitlyn ROGERS

IPC: G16B35/20 ,  G06N20/00 ,  G16B5/20 ,  G16H10/40 ,  G16H50/20

CPC classification number: G16B35/20 ,  G06N20/00 ,  G16B5/20 ,  G16H10/40 ,  G16H50/20

Abstract: Predictive engineering of a sample derived from a genetically optimized non-human donor suitable for xenotransplantation into a human having improved quality or performance is described. A training data set is constructed from a series of libraries, including at least one library comprising genomic, proteomic, and research data specific to non-humans. A predictive machine learning model is developed based on the constructed training data set and utilized to obtain a predicted quality or performance of a plurality of sequences for a candidate sample from the non-human donor specific to a human patient or patient population. A subset of sequences is selected for evaluation from the plurality of sequences based on the predicted quality or performance and candidate samples are designed derived from the non-human donor using the selected subset of sequences.

公开(公告)号：US20230203597A1

公开(公告)日：2023-06-29

申请号：US18056652

申请日：2022-11-17

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： David M. Kurtz ,  Maximilian Diehn ,  Arash Ash Alizadeh

IPC: C12Q1/6886 ,  G16B30/10 ,  G16B20/20 ,  G16B35/20 ,  G16B30/00 ,  C12Q1/6874 ,  G16H70/60 ,  G16H10/40 ,  G16H50/30 ,  G16H50/70 ,  G16H20/10 ,  G16B40/00 ,  G16B20/10 ,  C12N15/10 ,  G16H50/20 ,  C12Q1/6869

CPC classification number: C12Q1/6886 ,  G16B30/10 ,  G16B20/20 ,  G16B35/20 ,  G16B30/00 ,  C12Q1/6874 ,  G16H70/60 ,  G16H10/40 ,  G16H50/30 ,  G16H50/70 ,  G16H20/10 ,  G16B40/00 ,  G16B20/10 ,  C12N15/1089 ,  G16H50/20 ,  C12Q1/6869 ,  G16H10/60

Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.